Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation

Labisia pumila (Myrsinaceae), known as "Kacip Fatimah," has been used by many generations of Malay women to induce and facilitate child birth as well as a post partum medicine. However, its topical application on skin has not been reported yet. In this study, we have focused on the anti-photoaging effects of L. pumila. Extract of L. pumila was first analyzed for their antioxidant activities using DPPH (2,2-diphenyl-1-picrylhydrazyl) since UV irradiation is a primary cause of reactive oxygen species (ROS) generation in the skin. The 50% free radical scavenging activity (FSC(50)) of L. pumila extract was determined to be 0.006%, which was equal to that produced by 156 microM ascorbic acid. TNF-alpha and cyclooxygenase (COX-2) play a primary role in the inflammation process upon UV irradiation and are known to be stimulated by UVB. Treatment with L. pumila extract markedly inhibited the TNF-alpha production and the expression of COX-2. Decreased collagen synthesis of human fibroblasts by UVB was restored back to normal level after treatment with L. pumila extract. On the other hand, the enhanced MMP-1 expression upon UVB irradiation was down regulated by L. pumila extract in a dose-dependent manner. Furthermore, treatment of normal keratinocytes with L. pumila extract attenuated UVB-induced MMP-9 expression. These results collectively suggest L. pumila extract has tremendous potential as an anti-photoaging cosmetic ingredient

Current-induced domain wall motion in a nanowire with perpendicular magnetic anisotropy

We study theoretically the current-induced magnetic domain wall motion in a metallic nanowire with perpendicular magnetic anisotropy. The anisotropy can reduce the critical current density of the domain wall motion. We explain the reduction mechanism and identify the maximal reduction conditions. This result facilitates both fundamental studies and device applications of the current- induced domain wall motion

Effects of muscular response for the intensity of vibratory stimulus applied on the ankle tendon

The present study was conducted to measure the individual threshold value for the somatosensory system of the human body, the thresholds value of vibratory stimulus were assessed through the ascent and descent methods. In the interests of the attainment of this study`s goal, comparing the thresholds value measured and change of state of the muscles when applied on the ankle tendon connected to muscles, changes in threshold measurement accuracy due to the differences in measuring methods were discussed. The experiment was conducted by constructing systems to stimulate somethetic sensibility by vibratory stimulus, ultrasound imaging system and EMG system. Five adult males were involved in this experiment. According to the results of experiments, the threshold value of somatosensory stimulation measured by the ascent method was greater than the threshold values measured by the descent method. And the muscular response to the somatosensory stimulation applied to the tibialis anterior tendon showed a larger rate of change with the ascending stimulus than with the descending stimulus. The results of this study could serve as a basis to discuss the reliability of the measurement method of the human body’s individual threshold value for the somatosensory system through the ascent and descent methods and can be used as reference data for the integration and performance threshold measurement methods

A study on the change in the characteristics of the gait of elderly people when somatosensory stimulation was applied to their ankle joint

The gait is the most complicated, habitual, and involuntary activity of humans and is a result of the cooperation of the central and peripheral nervous systems that harmoniously mobilize the sensory receptors, nervous system, and muscles. A sensory signal binds to a somatosensory system proprioceptor to obtain information on posture. This study was designed to analyze the change in the characteristics of a gait when stimulation is applied in the somatosensory system that controls the balance of the body. A result of the GRF obtained from the force plate and gyroscope signals from the sensor attached on ankle joint were obtained to compare the change before and after the somatosensory stimulation. The result of this study proved a potential of somatosensory stimulation in improving balance, which could be used in studies on the balance of positions and gait improvement

A study on the changes in gait characteristics by applying sub-threshold vibration stimulus in the ankle

This study was conducted to suggest the potential use of a mechanical vibration stimulus in the ankle to correct gait abnormalities. As for the mechanical vibration stimulus, different locations and durations are suggested based on the detection results of real-time gait patterns. 5 young males participated in this study. They were asked to perform assigned gait tasks when either a threshold or sub-threshold stimulus was applied in the tibialis anterior and Achilles tendon. The analysis results of gait cycle and muscle activity showed the changes on gait cycle, the activity pattern of used muscle for gait and the movement pattern of the ankle were observed based on the applied locations of vibration stimulus. Also, the result of sub-threshold stimulus showed similar effects as that of threshold stimulus. As such, the mechanical vibration stimulus was considered to affect gait by being adjusted its characteristics and local stimulus also would affect human body systemically. The result of this study can be used as basic data for the correction of individual’s specific gait abnormality and rehabilitation using vibration stimulus

Constraints on Scalar-Field Dark Energy from the Cosmic Lens All-Sky Survey Gravitational Lens Statistics

We use the statistics of strong gravitational lensing based on the Cosmic Lens All-Sky Survey (CLASS) data to constrain cosmological parameters in a spatially-flat, inverse power-law potential energy density, scalar-field dark energy cosmological model. The lensing-based constraints are consistent with, but weaker than, those derived from Type Ia supernova redshift-magnitude data, and mildly favor the Einstein cosmological constant limit of this dark energy model.Comment: 10 pages, 1 figure; ApJL, in press; minor additions, new referenc

Genome sequence of the chromate-resistant bacterium Leucobacter salsicius type strain M1-8T

Leucobacter salsicius M1-8(T) is a member of the Microbacteriaceae family within the class Actinomycetales. This strain is a Gram-positive, rod-shaped bacterium and was previously isolated from a Korean fermented food. Most members of the genus Leucobacter are chromate-resistant and this feature could be exploited in biotechnological applications. However, the genus Leucobacter is poorly characterized at the genome level, despite its potential importance. Thus, the present study determined the features of Leucobacter salsicius M1-8(T), as well as its genome sequence and annotation. The genome comprised 3,185,418 bp with a G+C content of 64.5%, which included 2,865 protein-coding genes and 68 RNA genes. This strain possessed two predicted genes associated with chromate resistance, which might facilitate its growth in heavy metal-rich environments.

Soft Tissue Surgery for Equinus Deformity in Spastic Hemiplegic Cerebral Palsy: Effects on Kinematic and Kinetic Parameters

The purpose of this study was to evaluate how soft tissue surgery for correcting equinus deformity affects the kinematic and kinetic parameters of the ankle and proximal joints. Sixteen children with spastic hemiplegic cerebral palsy and equinus deformities (age range 3-16 years) were included. Soft tissue surgeries were performed exclusively on the ankle joint area in all subjects. Using computerized gait analysis (Vicon 370 Motion Analysis System), the kinematic and kinetic parameters during barefoot ambulation were collected preoperatively and postoperatively. In all 16 children, the abnormally increased ankle plantar flexion and pelvis anterior tilting on the sagittal plane were significantly improved without a weakening of push-off (p < 0.05). In a group of 8 subjects with a recurvatum knee gait pattern before operation, the postoperative kinematic and kinetic parameters of the knee joint were significantly improved (p < 0.05). In a group of 8 subjects with ipsilateral pelvic external rotation before operation, the postoperative pelvic deviations on the transverse plane were significantly decreased (p < 0.05). These findings suggest that the soft tissue surgery for correcting equinus deformity improves not only the abnormal gait pattern of the ankle, but also that of the knee and pelvis