2,023 research outputs found
Studi Hukum tentang Pelakasanaan Program Beras Sejahtera (Rastra) di Kelurahan Dualimpoe Kecamatan Maniangpajo Kabupaten Wajo
Abstrak. Skripsi, Jurusan Pendidikan Pancasila Dan Kewarganegaraan, Fakultas Ilmu Sosial Universitas Negeri Makassar. Dibimbing oleh A. Kasmawati dan Imam Suyitno.Penelitian ini bertujuan untuk mengetahui (1) mekanisme pelaksanaan program beras sejahtera melalui enam tepat di Kelurahan Dualimpoe Kecamatan Maniangpajo Kabupaten Wajo. (2) faktor penghambat dalam pelasanaan program beras sejahtera di Kelurahan Dualimpoe Kecamatan Maniangpajo Kabupaten Wajo . Untuk mencapai tujuan tersebut maka peneliti menggunakan metode penelitian dengan pendekatan kualitatif, jenis penelitian deskriftif kualitatif, sumber data primer yaitu informan sebanyak enam orang. Data sekunder yaitu dokumen. Teknik pengumpulan data melalui dokumentasi, observasi, dan wawancara. Teknik analisis data yang digunakan adalah deskriptif kualitatif.Hasil penelitian menunjukkan bahwa: (1) mekanisme Pelaksanaan Program Rastra Kelurahan Dualimpoe Kecamatan Maniangpajo Kabupaten Wajo, pelaksanaanya belum memenuhi keseluruhan indikator pencapaian program Rastra, diantaranya indikator tepat sasaran, tepat waktu, tepat administrasi, dan tepat kualitas. Dari ke enam indikator pencapaian program Rastra sebagaimana diatur dalam Petunjuk Teknis Program Rastra Kabupaten Wajo Tahun 2018 hanya dua indikator yang terpenuhi yaitu tepat jumlah dan tepat harga (2) faktor penghambat pelaksanaan program Rastra di Kelurahan Dualimpoe Kecamatan Maniangpajo Kabupaten Wajo adalah tidak menentunya penyaluran Rastra dari pihak BULOG. Pelaksana distribusi Rastra di Kelurahan Dualimpoe yang tidak disiplin, Selain itu penginformasian waktu pembagian beras yang terkendala sarana prasarana. Dan juga adanya KPM yang terkadang malas datang mengambil beras. Serta tidak adanya pemberitahuan saat nama KPM dihapus dari DPM. Dan juga tidak adanya pengawasan dari pemerintah setempat
Two-area analysis of system time deviation and inadvertent interchange energy accumulation in interconnected power systems
System time deviation and inadvertent interchange energy of an area are considered as a vector with two coordinates. For any one control area, the rest of the interconnection is considered as one equivalent area. The two-dimensional vector which represents system time deviation (epsilon) and inadvertent interchange energy I can be decomposed into two vector components: a component caused by the area itself, and a component caused by the rest of the interconnection. The former vector component represents the area component of the system time deviation and the primary component of inadvertent interchange energy as defined by Nathan Cohn. The latter vector component represents the area component of system time deviation and the secondary component of inadvertent interchange energy caused by the rest of the interconnection as defined by Cohn;The concept of vector decomposition can be illustrated on the two-dimensional Cartesian plane. This plane is called the ((epsilon),I) plane. Some properties of the effect of the control actions on system time deviation and inadvertent interchange energy are discussed. Control actions investigated are the automatic generation control actions and/or corrective control actions in and/or outside an area. Various corrective control schemes are investigated and illustrated. These corrective control schemes are compared in terms of energy (MWH) required for the control action;The causes of excessive accumulation of inadvertent interchanges encountered in the Western System Coordinating Council are investigated. The possible situations that can lead to excessive accumulation of inadvertent interchanges in the area of interest are investigated using an Automatic Generation Control (AGC) simulation program. Selective participation in the continuous, automatic time error correction scheme is also investigated;The validity of the decomposed vector components of an area itself and of the rest of the interconnection is checked using the AGC computer program. These results confirm the validity of the concept of vector decomposition;Finally, three examples of debit/credit computation, based on area components of system time deviation, are presented. With the help of the debit/credit system, the inadvertent interchange energy accounts of control areas can be adjusted properly in order to correct the system time deviation to zero with a minimum amount of regulation (MWH) in the whole interconnected power systems
Hyuk-Min Harry Kwon, Violin
Violin Sonata No. 3, Op. 108 / Johannes Brahms; Violin Sonata No. 3, Op. 45 / Edvard Grie
Pathophysiological role of MicroRNA-29 in pancreatic ductal adenocarcinoma
Indiana University-Purdue University Indianapolis (IUPUI)Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy and
responds poorly to current therapies. Thus, it is imperative to develop novel treatments
for PDAC. Dense fibrotic stroma associated with PDAC abrogates drug perfusion into
the tumor, and pancreatic stellate cells (PSCs) are the major stromal cells responsible for
fibrosis. Activated PSCs produce pro-inflammatory factors and secrete an excessive
amount of extracellular matrix (ECM) proteins, the major stromal proteins in PDAC.
MicroRNAs (miRNAs) are conserved small non-coding RNAs that regulate gene
expression by binding to the 3′UTR of target mRNA transcripts, causing translational
repression or degradation. A single miRNA regulates several targets within intracellular
networks and can have a profound impact on normal physiology.
miR-29 has been previously reported to have anti-fibrotic and tumor suppressive
roles in various cancers. We found miR-29 expression was significantly decreased in
activated PSCs and pancreatic cancer cells in vitro, in vivo models, as well as in PDAC
patient biopsies. Through in vitro studies in activated PSC, we found that miR-29
inhibited the expression of ECM proteins and reduced cancer growth when co-cultured
with pancreatic cancer cells. miR-29 overexpression in pancreatic cancer cells decreased
their invasive potential and sensitized chemoresistant cancer cells to gemcitabine
treatment by inhibiting autophagy through the direct targeting of two essential, autophagy
related genes, TFEB and ATG9A. In developing therapies and for in vivo functional studies, viral-based gene
delivery is a powerful tool to target the pancreas. We tested various self-complementary
recombinant adeno-associated virus (scAAV) serotypes in normal mice (C57BL/6) and in
a KrasG12D-driven pancreatic cancer mouse model via systemic and intraductal delivery
methods. We found that retrograde intraductal delivery of scAAV6 safely targeted the
pancreas/neoplasm with the greatest efficiency.
Our findings provide a better understanding of miR-29 in pancreatic cancer and
demonstrates its potential therapeutic use to target PDAC
Hyuk-Min Harry Kwon, Violin
Partita for Solo Violin No. 2 in D minor, BWV 1004 / J.S. Bach; Violin Concerto in E minor, Op. 64 / F. Mendelssoh
Decision Making for Insurance Eligibility based on Mortality Differential in Southeast Asian Countries
Indonesia, Malaysia, and Singapore are each at different stages of economic development, all have achieved sufficient size and economic strength that they are being prospected by several global life insurance and life annuities. Their economies have speedily been moving out of their traditional agrarian bases and becoming far more urbanized and industrialized. This study aims to compare the characteristics of various mortality risk factors between three countries in Southeast Asia (Indonesia, Malaysia, and Singapore) and analyze differences in mortality rates for the development of the life insurance busines
Tailoring hydrodynamics of non-wetting droplets with nano-engineered surfaces
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 47-53).Considering that contacts between liquid and solid are ubiquitous in almost all energy processes, including steam turbines, oil pumping, condensers and boilers, the efficiency of energy transportation can be maximized such that the liquid-solid interaction is optimized. Texture based super-hydrophobicity, also known as the Lotus effect, has been one of the most extensively studied topics in the last decade. Many of the recent studies have focused on how textures induce more water repellency, and how these textures can be manufactured with different methods and materials. However, few studies have shown how these surfaces benefit the real energy processes in which the interaction between liquid droplets and solid surfaces is vigorous and influences the energy transfer performances. This work focuses on altering the hydrodynamics of droplets with nano-engineered surfaces such that it enables a variety of energy transport processes to achieve better efficiency. Firstly, the wetting transition on textured super-hydrophobic surfaces is explored. The careful investigation of Cassie-Baxter to Wenzel transition of a pendant drop during the deposition explains that the rapid deceleration-induced water hammer pressure causes the transition. This new transition mechanism for large droplets enables a new wetting transition phase diagram with a previously known Laplace mechanism that explains the small drop transition. Another class of non-wetting droplet, the Leidenfrost drop, is studied with textured super-wetting surfaces. The liquid drop loses its contact to the solid by its own vapor, created by a large superheat from the solid. The Leidenfrost effect is undesirable in cooling applications as the vapor layer acts as a barrier for heat transfer. Here, it has been studied that how textured super-hydrophilic surfaces induce droplets to wet at higher superheat via capillary wicking compare to smooth surfaces. A physical model based on scaling is developed to predict the Leidenfrost drop on single length scale textures, and validated by the experiments. Additionally, the physical mechanism suggests that hierarchical textures have a higher Leidenfrost temperature compared to single-length-scale textures, confirmed experimentally. Lastly, the recently discovered rare-earth oxide ceramics are studied, which ensures the benefits of water repellency under harsh conditions such as high temperature and abrasive wear. Texturing of the rare-earth oxide ceramic is explored by the laser ablation technique. Unique micro- and nano-scale hierarchical textures are created, enhancing the water repellency, resulting in the super-hydrophobic rare-earth ceramic.by Hyuk-Min Kwon.Ph. D
Amino acids, polyamines, and nitric oxide synthesis in the ovine conceptus
The objective of this study was to determine concentrations of amino acids and polyamines as well as nitric oxide (NO) and polyamine synthesis in the ovine conceptus (embryo/fetal and associated placental membrane). Ewes were hysterectomized on Days 30, 40, 60, 80, 100, 120, or 140 of gestation to obtain allantoic and amniotic fluids, intercotyledonary placenta, placentomes and uterine endometrium for the analyses. Alanine, citrulline plus glutamine accounted for about 80% of total α-amino acids in allantoic fluid during early gestation. Serine (16.5 mM) contributed about 60% of total α-amino acids in allantoic fluid on Day 140 of gestation. Maximal ornithine decarboxylase (ODC) and arginase activities and highest rates of polyamine and NO synthesis occured in all tissues on Day 40 of gestation. In ovine allantoic and amniotic fluids, polyamines were most abundant during early (Days 40-60) and late (Days 100-140) gestation, respectively. Activity of guanosine 5??-triphosphate-cyclohydrolase I (GTP-CH), and concentrations of NOS cofactors, tetrahydrobiopterin (BH4) and NADPH (nicotinamide adenine dinucleotide), peaked on Day 40 of gestation in placental and endometrial tissues. In these tissues, NO synthesis was positively correlated with total NOS activity, GTP-CH activity, and concentrations of BH4 and NADPH. The physiological significance of these changes was manifested by undernutrition-induced intrauterine growth retardation (IUGR). Maternal undernutrition (50% of National Research Council nutrient requirements) reduced concentrations of total α-amino acids in fetal plasma and fluids, and retarded fetal growth at both mid (Day 78) and late (Day 135) gestation. Concentrations of polyamines in fetal fluids were lower in underfed ewes than in control-fed ewes. Realimentation of underfed ewes between Days 78 and 135 of gestation increased concentrations of total α-amino acids and polyamines in fetal plasma and fluids, when compared with non-realimented ewes. Results of these studies demonstrate metabolic coordination among the several integrated pathways to enable high rates of polyamine and NO synthesis in the placenta and endometrium during early pregnancy. Collectively, our findings may have important implications for both IUGR and fetal origins of adult disease
- …