Development of Components of Analog and Digital Gauges for Training Regulators Safety Check using Virtual Reality

The inspection and check of the pressure regulation facility should be achieved, because it is mandatory item on law of gas safety management. It is more effective education using 3D virtual reality to enable injecting real combustible and toxic gas. Also it give immersion to trainee with virtual experience. In here, we reviewed education on the pressure regulating facility using virtual reality technology and designed a safety training scenario for decomposing and checking the pressure regulators on VR screen. And then we implemented components of an analog and digital pressure gauges using 3D Unity tool to visualize them on the VR education system. Trainee can be educated efficiently interacting their 3D virtual engine with components such as pressure gauges, pipelines, valves, and practical environments. Its effectiveness is demonstrated at the result through questionnaire. Its positive answer of three main inquiries is more 93%. We hope gas risks are reduced by using our virtual education contents at various industrial fields

Concise Synthesis of Broussonone A

A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition

Star-shaped hole transporting materials with a triazine unit for efficient perovskite solar cells

Novel star-shaped hole transporting materials with a triazine unit have been synthesized. When the new Triazine-Th-OMeTPA was used as a hole transporting material in perovskite solar cells, the power conversion efficiency reached 12.51% under AM 1.5 G (100 mW cm(-2)) illumination, showing competitive photovoltaic performance with the widely used spiro-OMeTAD based solar cell (13.45%)

Ellagic Acid Identified through Metabolomic Analysis Is an Active Metabolite in Strawberry (‘Seolhyang’) Regulating Lipopolysaccharide-Induced Inflammation

This study employed the metabolomic approach to identify the key constituent exerting anti-inflammatory activity in murine macrophage RAW 264.7 cells. Among the six different fractions (SF1–SF6) of the strawberry ‘Seolhyang’, SF4 showed more significant inhibition on iNOS expression than SF3, and ellagic acid was determined as the most significant different component between SF4 and SF3 using orthogonal partial least-squares discriminant analysis. Ellagic acid (0.3 and 1.0 μM) and SF4 (100 μg/mL) were found to regulate the same inflammatory mediators, inhibitory κB (IκB) and mitogen-activated protein kinases (MAPKs), which led to the reduction of tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and iNOS expressions. These results demonstrate that ellagic acid from strawberry ‘Seolhyang’ is the major component playing a crucial role in inflammation, suggesting the possible application of metabolomic analysis to determining the key ingredients having biological functions in the complicated food matrix

Concise Synthesis of Broussonone A

A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition

Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-κB Inhibitors and Cytotoxic Agents

1,2,3,4-Tetrahydroquinolines have been identified as the most potent inhibitors of LPS-induced NF-κB transcriptional activity. To discover new molecules of this class with excellent activities, we designed and synthesized a series of novel derivatives of 1,2,3,4-tetrahydroquinolines (<b>4a</b>–<b>g</b>, <b>5a</b>–<b>h</b>, <b>6a</b>–<b>h</b>, and <b>7a</b>–<b>h</b>) and bioevaluated their <i>in vitro</i> activity against human cancer cell lines (NCI-H23, ACHN, MDA-MB-231, PC-3, NUGC-3, and HCT 15). Among all synthesized scaffolds, <b>6g</b> exhibited the most potent inhibition (53 times that of a reference compound) of LPS-induced NF-κB transcriptional activity and the most potent cytotoxicity against all evaluated human cancer cell lines