1,245 research outputs found

    ์™ธ๋ถ€์ง€์‹์˜ ํƒ์ƒ‰์ด ํ˜์‹ ์„ฑ๊ณผ์™€ ํ˜์‹ ์†๋„์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ฒฝ์˜ํ•™๊ณผ ๊ตญ์ œ๊ฒฝ์˜์ „๊ณต, 2015. 8. ์ด๋™๊ธฐ.Since Chesbrough (2003) brought up the idea of open innovation, many firms have used open search strategy. This paper tries to examine the effect of external search on innovation performance and speed. Based on Korean Innovation Survey (KIS) of 1353 manufacturing firms in Korea, I find that searching deeply from external sources is positively related to radical innovation performance. In contrast, searching broadly from external sources is positively related to incremental innovation performance. In addition, search breadth is negatively related to innovation speed. These findings implicate that aligning open search strategy with a firms goal is important. In other words, searching deeply or broadly may depend on whether the firm intends to introduce new to world products or new to firm products. Also, firms should consider innovation speed in applying search strategy.INTRODUCTION THEORY AND HYPOTHESES - Open innovation and external search - Radical innovation, incremental innovation, and external search - Search breadth, depth and innovation speed DATA AND METHODS - Sample - Dependent variables - Independent variables - Control variables - Estimation RESULTS DISCUSSION AND CONCLUSIONS - Limitations and future research - Implications for managersMaste

    Concomitant enhancement of electron-phonon coupling and electron-electron interaction in graphene decorated with ytterbium

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    The interplay between electron-electron interaction and electron-phonon coupling has been one of the key issues in graphene as it can provide information on the origin of enhanced electron-phonon coupling in graphene by foreign atoms. In ytterbium-decorated graphene on SiC substrate, electron-phonon coupling exhibits strong enhancement compared to that of as-grown graphene. Based on angle-resolved photoemission study, the presence of ytterbium is also found to result in the decrease of Fermi velocity, revealing the enhancement of electron-electron interaction within the Fermi liquid theory. Our finding on the concomitant enhancement of electron-electron interaction and electron-phonon coupling suggests a possibility of the interplay between the two representative many-body interactions in graphene decorated with foreign atoms.Comment: 3 figure

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    ??????????????? ????????? ???????????? ???????????? ?????? ?????????????????? ??????????????? ?????? ???????????? ??????. ??? ??????????????? ??????????????? ??? ?????? ????????? ???????????? ????????? ??????????????? ????????? ???????????????. ?????? ??????????????? ????????? ??? ?????? ????????? ???????????????, ??? ?????? ????????? diethylnitrosamine (DEN)??? C3H/HeN ?????? ?????? ?????? ???????????? ??? ?????? ????????? ????????? ???????????????. DEN?????? ????????? ???????????? ?????? alkaline phosphatase (ALP) ??????, TUNEL positive ???????????? ??????, ??? ???????????? ?????? ???????????? duct??? ??????, ?????????????????? ????????????, Masson???s trichrome ???????????? ????????? ???????????? ???, ?????? ?????? ?????? ??? ????????? ????????? ???????????? ?????? ???????????? ?????? ?????? ????????? ??? ?????????. ?????????, ??????????????? ?????? ???????????? ????????? ?????? ?????????????????? ??????, ?????? ?????? ??? ????????? ???????????? ??????????????? ???????????? ???????????? ???????????? ?????? ?????? ????????? ??? ?????????. ???????????? ???????????? ????????? ???????????? ??????, ???????????? ???????????? ???????????? ?????? ????????? ???, solvent partition ????????? ???????????? ????????? ???????????? hexane, ethyl acetate, water ???????????? ???????????????. ?????? ??????????????? ?????? ????????? ??????????????? ??????????????? ???, ethyl acetate ???????????? ??????????????? ????????? ?????????????????? ??????????????? ?????? ??????????????? ???????????? ????????? ????????? ????????? ??? ?????????. ????????? ethyl acetate???????????? ???????????? ????????? ????????? ??? ?????????, ??????????????? ????????? ??? ?????? ????????? ????????? ?????????. ???????????????, ??????????????? ????????? ????????????????????? ?????? ????????? ??? ?????? ????????? ???????????? ?????? ??????????????? ????????? ??? ?????? ????????? ????????? ????????? ?????? ???????????????. ?????????, ?????? ??????????????? ?????? ???????????? ?????? ??? ?????? ?????? ???????????? ??????????????? ?????? ????????? ????????? ??? ?????? ????????? ???????????? ??????.clos

    Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays.

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    A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs). In comparison to other aptamer-target pairs, the aptamer-based adenosine triphosphate (ATP) detection assays are limited by the relatively weak binding between the two partners. In response, a series of MBAs were designed that have different stem stabilities while keeping the constant ATP-specific aptamer sequence in the loop part. The MBAs are labeled with a fluorophore and a quencher at both termini. In the absence of ATP, the hairpin MBAs can be opened by CPEs via a combination of electrostatic and hydrophobic interactions, showing a FRET-sensitized fluorophore signal. In the presence of ATP, the aptamer forms a G-quadruplex and the FRET signal decreases due to tighter contact between the fluorophore and quencher in the ATP/MBA/CPE triplex structure. The FRET-sensitized signal is inversely proportional to [ATP]. The extension of the detection range is determined by the competition between opening of the ATP/MBA G-quadruplex by CPEs and the composite influence by ATP/aptamer binding and the stem interactions. With increasing stem stability, the weak binding of ATP and its aptamer is successfully compensated to show the resistance to disruption by CPEs, resulting in a substantially broadened detection range (from millimolar up to nanomolar concentrations) and a remarkably improved limit of detection. From a general perspective, this strategy has the potential to be extended to other chemical- and biological-assays with low target binding affinity

    Mitsugumin-29 Regulates RyR1 Activity In Mouse Skeletal Myotubes

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    The association between new graphic health warning labels on tobacco products and attitudes toward smoking among south Korean adolescents: a national cross-sectional study

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    Background Graphic health warning labels (GHWLs) on tobacco products are more effective than text warnings for communicating the risk of smoking. The implementation of GHWLs can prevent adolescents from initiating smoking. Therefore, this study examined the association between GHWLs newly implemented on December 23, 2016, in South Korea and attitudes toward smoking among adolescents. Methods This post-implementation cross-sectional analysis examined the responses of 62,276 students (31,624 boys and 30,652 girls) who participated in the 2017 Web-based Korean Youth Risk Behavior Survey, which was completed anonymously as a self-administered questionnaire by middle and high school students. Multinomial logistic regression was applied to explore the attitudes toward smoking among the youth (13โ€“18โ€‰years old) who have been exposed to GHWLs in order to identify relationship of exposure to the GHWLs with smoking initiation and awareness of the danger of smoking. Results Six months after implementation, 69.4% of adolescents reported having been exposed to GHWLs in the previous 30โ€‰days. Among those exposed to GHWLs both boys and girls in grade 7 were significantly more likely than grade 12 high school students to decide not to start smoking (boys: AORโ€‰=โ€‰3.96, 95% CI 3.31โ€“4.75, pโ€‰<โ€‰0.001; girls: AORโ€‰=โ€‰2.76, 95% CI 2.32โ€“3.30, pโ€‰<โ€‰0.001) and to think that smoking was dangerous to their health (boys: AORโ€‰=โ€‰3.01, 95% CI 2.52โ€“3.58, pโ€‰<โ€‰0.001; girls: AORโ€‰=โ€‰2.42, 95% CI 2.03โ€“3.88, pโ€‰<โ€‰0.001) after seeing GHWLs. These associations were greater for adolescents who had experienced smoking-prevention education or had been exposed to anti-tobacco advertisements. However, those who smoked, used e-cigarettes, or experienced secondhand smoking were significantly less likely to decide not to smoke and to view smoking as dangerous. Conclusions To maintain the perception of the harm of tobacco from childhood through adolescence, the government should implement both comprehensive tobacco controls, including smoking-prevention education in schools, and measures to encourage a smoke-free environment in homes.This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (No. 2020R1C1C1012562)

    ESTIMATION AND CORRECTION OF THE UNCONTROLLED BEAM LOSS DUE TO THE ALIGNMENT ERROR IN THE LOW-ENERGY LINEAR ACCELERATOR OF RAON

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    Abstract RAON(Rare isotope Accelerator Of Newness) mainly consists of the front-end system, ISOL system, reaccelerator for ISOL system, charge stripper section and main linear accelerator(linac) for ECR ion sourc

    Identification of a Kitaev Quantum Spin Liquid by Magnetic Field Angle Dependence

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    Quantum spin liquids realize massive entanglement and fractional quasiparticles with localized spins, proposed as an avenue for quantum science and technology. In particular, topological quantum computations are suggested in the non-abelian phase of Kitaev quantum spin liquid with Majorana fermions, and detection of Majorana fermions is one of the most outstanding problems in modern condensed matter physics. Here, we propose a concrete way to identify the non-abelian Kitaev quantum spin liquid by magnetic field angle dependence. Topologically protected critical lines exist on a plane of magnetic field angles, and their shapes are determined by microscopic Hamiltonian information. A chiral spin operator plays a key role to detect the critical lines varying with magnetic field angles, and experimental criteria for the non-abelian spin liquid state are provided. Our proposal may be employed as a new route to probe a non-abelian quantum spin liquid in addition to the half-quantization of thermal Hall conductivity.Comment: 12 pages, 8 figures, 2 table

    Gapped Nearly Free-Standing Graphene on an SiC(0001) Substrate Induced by Manganese Atoms

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    The electron band structure of manganese-adsorbed graphene on an SiC(0001) substrate has been studied using angle-resolved photoemission spectroscopy. Upon introducing manganese atoms, the conduction band of graphene completely disappears and the valence band maximum is observed at 0.4 eV below Fermi energy. At the same time, the slope of the valence band decreases, approaching the electron band structure calculated using the local density approximation method. While the former provides experimental evidence of the formation of nearly free-standing graphene on an SiC substrate, concomitant with a metal-to-insulator transition, the latter suggests that its electronic correlations can be modified by foreign atoms. These results pave the way for promising device applications using graphene that is semiconducting and charge neutral.Comment: 16 pages, 3 figure
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