A Study of the 20 Day Superorbital Modulation in the High-Mass X-ray Binary IGR J16493-4348

We report on Nuclear Spectroscopic Telescope Array (NuSTAR), Neil Gehrels Swift Observatory (Swift) X-ray Telescope (XRT) and Swift Burst Alert Telescope (BAT) observations of IGR J16493-4348, a wind-fed Supergiant X-ray Binary (SGXB) showing significant superorbital variability. From a discrete Fourier transform of the BAT light curve, we refine its superorbital period to be 20.058 $\pm$ 0.007 days. The BAT dynamic power spectrum and a fractional root mean square analysis both show strong variations in the amplitude of the superorbital modulation, but no observed changes in the period were found. The superorbital modulation is significantly weaker between MJD 55,700 and MJD 56,300. The joint NuSTAR and XRT observations, which were performed near the minimum and maximum of one cycle of the 20 day superorbital modulation, show that the flux increases by more than a factor of two between superorbital minimum and maximum. We find no significant changes in the 3-50 keV pulse profiles between superorbital minimum and maximum, which suggests a similar accretion regime. Modeling the pulse-phase averaged spectra we find a possible Fe K$\alpha$ emission line at 6.4 keV at superorbital maximum. The feature is not significant at superorbital minimum. While we do not observe any significant differences between the pulse-phase averaged spectral continua apart from the overall flux change, we find that the hardness ratio near the broad main peak of the pulse profile increases from superorbital minimum to maximum. This suggests the spectral shape hardens with increasing luminosity. We discuss different mechanisms that might drive the observed superorbital modulation.Comment: 17 pages, 14 figures, 3 tables, accepted for publication in The Astrophysical Journal on 2019 May 1

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils.

Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 co-infection are high. DFT1 gradually accumulates copy number variants (CNVs) and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.This work was supported by grants from Wellcome (102942/Z/13/A), the National Science Foundation (DEB-1316549), the University of Tasmania Foundation (Eric Guiler Tasmanian Devil Research Grants), the Australian Research Council (DE 170101116) and a Philip Leverhulme Prize from the Leverhulme Trust. YMK was supported by a Herchel Smith Postgraduate Fellowship

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche

Signatures of wakefield acceleration in astrophysical jets via gamma-rays and UHECRs

We present six case studies from a comprehensive mass range (1-109 M⊙) of astrophysical objects, each of which possess jets, emit high-energy gamma radiation and in some instances spatially identifiable ultra-high-energy cosmic rays (UHECRs). All sources are strong candidates for UHECR emission, if not already known to emit them. We surmise that wakefield acceleration in conjunction with the magnetorotational instability of the accretion disc explains both structural properties of the jets and details in their emission signals, such as correlations in neutrino and gamma-ray bursts, and in the case of blazars, anticorrelations in flux and spectral index. Furthermore, our model predicts an upper bound for the energy of UHECRs emitted from a source given the mass of its central compact object and total jet luminosity. To provide context for our model predictions, we quantitatively compare them with observational data, however, we have not accounted for the GZK limit and assumed universal values for several model parameters (e.g. jet-spreading index, p) that likely differ between sources. Since the accretion and acceleration mechanisms are independent of mass, aside from determining maximum values, blazars (∼109 M⊙), radio galaxies (∼ 108 M⊙), Seyfert galaxies (∼ 106 M⊙ ), starburst galaxies (∼ 103 M⊙ ), even microquasars (1-10 M⊙) interestingly exhibit the same physics. Other radiation bands, such as X-ray, ultraviolet, or radio, may harbour additional information, but we chose not to focus on them for brevity. However, such an endeavour may open the door to a new multimessenger approach for understanding these objects

A Study of the 20 day Superorbital Modulation in the High-mass X-Ray Binary IGR J16493-4348

We report on Nuclear Spectroscopic Telescope Array (NuSTAR), Neil Gehrels Swift Observatory (Swift) X-ray Telescope (XRT), and Swift Burst Alert Telescope (BAT) observations of IGR J16493-4348, a wind-fed supergiant X-ray binary showing significant superorbital variability. From a discrete Fourier transform of the BAT light curve, we refine its superorbital period to be 20.058 ± 0.007 days. The BAT dynamic power spectrum and a fractional root mean square analysis both show strong variations in the amplitude of the superorbital modulation, but no observed changes in the period are found. The superorbital modulation is significantly weaker between MJD 55,700 and MJD 56,300. The joint NuSTAR and XRT observations, which were performed near the minimum and maximum of one cycle of the 20 day superorbital modulation, show that the flux increases by more than a factor of two between superorbital minimum and maximum. We find no significant changes in the 3-50 keV pulse profiles between superorbital minimum and maximum, which suggests a similar accretion regime. Modeling the pulse-phase-averaged spectra we find a possible Fe Kα emission line at 6.4 keV at superorbital maximum. This feature is not significant at superorbital minimum. While we do not observe any significant differences between the pulse-phase-averaged spectral continua apart from the overall flux change, we find that the hardness ratio near the broad main peak of the pulse profile increases from superorbital minimum to maximum. This suggests the spectral shape hardens with increasing luminosity. We discuss different mechanisms that might drive the observed superorbital modulation