Short communication: Landlab v2.0: a software package for Earth surface dynamics

Numerical simulation of the form and characteristics of Earth's surface provides insight into its evolution. Landlab is an open-source Python package that contains modularized elements of numerical models for Earth's surface, thus reducing time required for researchers to create new or reimplement existing models. Landlab contains a gridding engine which represents the model domain as a dual graph of structured quadrilaterals (e.g., raster) or irregular Voronoi polygon-Delaunay triangle mesh (e.g., regular hexagons, radially symmetric meshes, and fully irregular meshes). Landlab also contains components - modular implementations of single physical processes - and a suite of utilities that support numerical methods, input/output, and visualization. This contribution describes package development since version 1.0 and backward-compatibility-breaking changes that necessitate the new major release, version 2.0. Substantial changes include refactoring the grid, improving the component standard interface, dropping Python 2 support, and creating 31 new components - for a total of 58 components in the Landlab package. We describe reasons why many changes were made in order to provide insight for designers of future packages. We conclude by discussing lessons about the dynamics of scientific software development gained from the experience of using, developing, maintaining, and teaching with Landlab.</p

Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop

<p>Abstract</p> <p>Background</p> <p>Envenomation by crotaline snakes (rattlesnake, cottonmouth, copperhead) is a complex, potentially lethal condition affecting thousands of people in the United States each year. Treatment of crotaline envenomation is not standardized, and significant variation in practice exists.</p> <p>Methods</p> <p>A geographically diverse panel of experts was convened for the purpose of deriving an evidence-informed unified treatment algorithm. Research staff analyzed the extant medical literature and performed targeted analyses of existing databases to inform specific clinical decisions. A trained external facilitator used modified Delphi and structured consensus methodology to achieve consensus on the final treatment algorithm.</p> <p>Results</p> <p>A unified treatment algorithm was produced and endorsed by all nine expert panel members. This algorithm provides guidance about clinical and laboratory observations, indications for and dosing of antivenom, adjunctive therapies, post-stabilization care, and management of complications from envenomation and therapy.</p> <p>Conclusions</p> <p>Clinical manifestations and ideal treatment of crotaline snakebite differ greatly, and can result in severe complications. Using a modified Delphi method, we provide evidence-informed treatment guidelines in an attempt to reduce variation in care and possibly improve clinical outcomes.</p