THE INFLUENCE OF OXYTOCIN ON THE PRODUCTION OF PROSTAGLANDINS IN VITRO AND IN VIVO

Peer Reviewe

Pairing Correlations in the Two-Dimensional Hubbard Model

We present the results of a quantum Monte Carlo study of the extended $s$ and the $d_{x^2-y^2}$ pairing correlation functions for the two-dimensional Hubbard model, computed with the constrained-path method. For small lattice sizes and weak interactions, we find that the $d_{x^2-y^2}$ pairing correlations are stronger than the extended $s$ pairing correlations and are positive when the pair separation exceeds several lattice constants. As the system size or the interaction strength increases, the magnitude of the long-range part of both correlation functions vanishes.Comment: 4 pages, RevTex, 4 figures included; submitted to Phys. Rev. Let

Microscopic description of d-wave superconductivity by Van Hove nesting in the Hubbard model

We devise a computational approach to the Hubbard model that captures the strong coupling dynamics arising when the Fermi level is at a Van Hove singularity in the density of states. We rely on an approximate degeneracy among the many-body states accounting for the main instabilities of the system (antiferromagnetism, d-wave superconductivity). The Fermi line turns out to be deformed in a manner consistent with the pinning of the Fermi level to the Van Hove singularity. For a doping rate $\delta \sim 0.2$, the ground state is characterized by d-wave symmetry, quasiparticles gapped only at the saddle-points of the band, and a large peak at zero momentum in the d-wave pairing correlations.Comment: 4 pages, 2 Postscript figure

Enhancement of the d_{x^2-y^2} pairing correlation in the two-dimensional Hubbard model: a quantum Monte Carlo study

Quantum Monte Carlo is used to investigate the possibility of d_{x^2-y^2} superconductivity in the two-dimensional repulsive Hubbard model. A small energy scale relevant to possible pairing requires a care (i.e., sufficiently small level separation between the $k$ points $(\delta k,\pi-\delta k')$ and $(\pi-\delta k'',\delta k''')$ with small $\delta k$'s) to detect enhanced correlations in finite-size studies, as motivated from a previous study on Hubbard ladders. Our calculation indeed detects long-tailed enhancements in the d_{x^2-y^2} pairing correlation when the system is near, but not exactly at, half-filling.Comment: 4 pages, RevTeX, uses epsf.sty and multicol.st

Quantum Monte Carlo Evidence for d-wave Pairing in the 2D Hubbard Model at a van Hove Singularity

We implement a Quantum Monte Carlo calculation for a repulsive Hubbard model with nearest and next-nearest neighbor hopping interactions on clusters up to 12x12. A parameter region where the Fermi level lies close to the van Hove singularity at the Saddle Points in the bulk band structure is investigated. A pairing tendency in the $d_{x^2-y^2}$ symmetry channel, but no other channel, is found. Estimates of the effective pairing interaction show that it is close to the value required for a 40 K superconductor. Finite-size scaling compares with the attractive Hubbard model.Comment: 11 pages, REVTex, 4 figures, postscrip

Ground state of the three-band Hubbard model

The ground state of the two-dimensional three-band Hubbard model in oxide superconductors is investigated by using the variational Monte Carlo method. The Gutzwiller-projected BCS and spin- density wave (SDW) functions are employed in the search for a possible ground state with respect to dependences on electron density. Antiferromagnetic correlations are considerably enhanced near half-filling. It is shown that the d-wave state may exist away from half-filling for both the hole and electron doping cases. The overall structure of the phase diagram obtained by the calculations qualitatively agrees with experimental indications. The superconducting condensation energy is in reasonable agreement with the experimental value obtained from specific heat and critical magnetic field measurements for optimally doped samples. The inhomogeneous SDW state is also examined near 1/8-hole doping.Comment: 10 pages, 17 figure

Capturing Aesthetic Experiences With Installation Art: An Empirical Assessment of Emotion, Evaluations, and Mobile Eye Tracking in Olafur Eliasson’s “Baroque, Baroque!”

Installation art is one of the most important and provocative developments in the visual arts during the last half century and has become a key focus of artists and of contemporary museums. It is also seen as particularly challenging or even disliked by many viewers, and—due to its unique in situ, immersive setting—is equally regarded as difficult or even beyond the grasp of present methods in empirical aesthetic psychology. In this paper, we introduce an exploratory study with installation art, utilizing a collection of techniques to capture the eclectic, the embodied, and often the emotionally-charged viewing experience. We present results from an investigation of two pieces, both part of Olafur Eliasson’s exhibition “Baroque, Baroque” held at the Belvedere museum in Vienna. These were assessed by pre- and post-viewing questionnaires focusing on emotion, meaning-making, and appraisals, in tandem with mobile eye tracking to consider viewers’ attention to both installed artworks and/or to the museum environment. The data showed differences in participants’ emotional states, appraisals, and visual exploration, which together paint a picture of the aesthetic reactions to the works. These differences also showed how viewers’ appraisal strategies, meaning making, and physical actions facilitated relatively more or less deep engagement with, and enjoyment of, the art. The results are discussed in terms of their implications for museum studies, art education, and theory in empirical aesthetics

Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach

Owing to their unique functions in regulating glucose, lipid and cholesterol metabolism, PPARs (peroxisome proliferator-activated receptors) have drawn special attention for developing drugs to treat type-2 diabetes. By combining the lipid benefit of PPAR-alpha agonists (such as fibrates) with the glycemic advantages of the PPAR-gamma agonists (such as thiazolidinediones), the dual PPAR agonists approach can both improve the metabolic effects and minimize the side effects caused by either agent alone, and hence has become a promising strategy for designing effective drugs against type-2 diabetes. In this study, by means of the powerful “core hopping” and “glide docking” techniques, a novel class of PPAR dual agonists was discovered based on the compound GW409544, a well-known dual agonist for both PPAR-alpha and PPAR-gamma modified from the farglitazar structure. It was observed by molecular dynamics simulations that these novel agonists not only possessed the same function as GW409544 did in activating PPAR-alpha and PPAR-gamma, but also had more favorable conformation for binding to the two receptors. It was further validated by the outcomes of their ADME (absorption, distribution, metabolism, and excretion) predictions that the new agonists hold high potential to become drug candidates. Or at the very least, the findings reported here may stimulate new strategy or provide useful insights for discovering more effective dual agonists for treating type-2 diabetes. Since the “core hopping” technique allows for rapidly screening novel cores to help overcome unwanted properties by generating new lead compounds with improved core properties, it has not escaped our notice that the current strategy along with the corresponding computational procedures can also be utilized to find novel and more effective drugs for treating other illnesses