HYBRID LIFE CYCLE SUSTAINABILITY ASSESSMENT OF LIQUIFIED NATURAL GAS SUPPLY CHAIN

Integrating sustainability into the distribution network process is a significant problem for any industry hoping to prosper or survive in today's fast-paced environment. Since gas is one of the world's most important fuel sources, sustainability is more important for the gas industry. While such environmental and economic effects have been extensively researched in the literature, there is little emphasis on the full social sustainability of natural gas production and supply chains in terms of the triple bottom line. The basic objective of this dissertation is to perform the first hybrid life cycle sustainability assessment (LCSA) of liquefied natural gas and evaluate its performance from natural gas extraction to LNG regasification after delivery through a maritime transport carrier. LCSA is used for estimating the social, economic, and environmental impacts of processes, and our life cycle model included the multi-region input-output analysis, Aspen HYSYS, and LNG maritime transport operations sustainability assessment tools. The results spot the light on the most contributors of CO2-eq emission. It is found that LNG loading (export terminal) is the source that generated the highest carbon footprint, followed by the MDEA sweetening unit with the contribution of 40% and 24%, respectively. Socially, around 73% of human health impact comes from SRU and TGTU units, which contribute most to particulate matter emissions. Based on the interpretation of life cycle results, the environmental indicators show better performance in the pre-separation unit and LNG receiving terminal representing a sustainability factor equal to 1. In terms of social and economic impacts, the natural gas extraction stage presents the best performance among all other stages, with a sustainability factor equal to 1. Based on this study's findings, an integrated framework model is proposed. Various suggestions for sustainability strategies and policies that consider business sustainability and geopolitics risk are presented

How sustainable is liquefied natural gas supply chain? An integrated life cycle sustainability assessment model

Integrating sustainability into the distribution network process is a significant problem for any industry hoping to prosper or survive in today's fast-paced environment. Since gas is one of the world's most important fuel sources, sustainability is more important for the gas industry. While such environmental and economic effects have been extensively researched in the literature, there is little emphasis on the full social sustainability of natural gas production and supply chains in terms of the triple bottom line. This research aims to perform the first hybrid life cycle sustainability assessment (LCSA) of liquefied natural gas and evaluate its performance from the natural gas extraction stage to LNG regasification after delivery through maritime transport carriers. LCSA is used for estimating the social, economic, and environmental impacts of processes, and our life cycle model included the multi-region input–output analysis, Aspen HYSYS, and LNG maritime transport operations sustainability assessment tools. The results spot the light on the most contributors of CO2-eq emission. It is found that LNG loading (export terminal) is the source that generated the highest carbon footprint, followed by the MDEA sweetening unit with the contribution of 40% and 24%, respectively. Socially, around 73% of human health impact comes from SRU and TGTU units which are the most contributors to the particulate matter emission. Based on the interpretation of life cycle results, the environmental indicators show better performance in the pre-separation unit and LNG receiving terminal representing a sustainability factor equal to 1. In terms of social and economic impacts, the natural gas extraction stage presents the best performance among all other stages, with a sustainability factor equal to 1. Based on this study's findings, an integrated framework model is proposed. Various suggestions for sustainability strategies and policies that consider business sustainability and geopolitics risk are presented

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

A Novel Hybrid Life Cycle Assessment Approach to Air Emissions and Human Health Impacts of Liquefied Natural Gas Supply Chain

Global interest in LNG products and supply chains is growing, and demand continues to rise. As a clean energy source, LNG can nevertheless emit air pollutants, albeit at a lower level than transitional energy sources. An LNG plant capable of producing up to 126 MMTA was successfully developed and simulated in this study. A hybrid life cycle assessment model was developed to examine the social and human health impacts of the LNG supply chain’s environmental air emission formation. The Multiregional Input–Output (MRIO) database, the Aspen HYSYS model, and the LNG Maritime Transportation Emission Quantification Tool are the key sources of information for this extensive novel study. We began our research by grouping environmental emissions sources according to the participation of each stage in the supply chain. The MDEA Sweetening plant, LNG loading (export terminal), and LNG transportation stages were discovered to have the maximum air emissions. The midpoint air emissions data estimated each stage’s CO2-eq, NOx-eq, and PM2.5-eq emissions per unit LNG generated. According to the midpoint analysis results, the LNG loading terminal has the most considerable normalized CO2-eq and NOx-eq emission contribution across all LNG supply chain stages. Furthermore, the most incredible intensity value for normalized PM2.5-eq was recorded in the SRU and TGTU units. Following the midpoint results, the social human health impact findings were calculated using ReCiPe 2016 characterization factors to quantify the daily loss of life associated with the LNG process chain. SRU and TGTU units have the most significant social human health impact, followed by LNG loading (export terminal) with about 7409.0 and 1203.9 (DALY/million Ton LNG produced annually), respectively. Natural gas extraction and NGL recovery and fractionation units are the lowest for social human health consequences

Integrated sustainability assessment of sharing economy models: The case for Qatar

This research is another contribution to the value of the sharing economy. Many applications are used worldwide for individual and group market sharing either Business-to-Business, Business-to-Customer, or Customer-to-Customer business models. In this research, we briefly illustrated 9 applications of the sharing economy. However, as the sharing economy phenomena grow, Triple Bottom Lines (TBL) for sustainability has to be evaluated for positive and negative impacts to ensure the quality of the business model as well as continuous improvement. Three methods of assessment were introduced: 1) Product Life Cycle Assessment, 2) Supply Chain Network & Saving and 3) Social Media Analysis of Sharing Economy Platform Website. Based on the literature review findings, many benefits and opportunities for improvement were addressed and summarized. As a result, the lesson learned analysis and recommendations were contributed to this research for the State of Qatar case. The sharing economy is a great global innovation and a proven high level of success. Consequently, researchers shall continue to study different business models and convert them into better market sharing by considering the sustainability, supply chain, policy implications, and other local and international legislation requirements. The authors also recommend widespread adoption of circular economy applications such as carsharing, home-sharing, for the FIFA World Cup Qatar 2022

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

BackgroundEstimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.Methods22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution.FindingsGlobal all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations.InterpretationGlobal adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic