Developing a critical appreciative process to review frameworks for social enterprise education

The object of this paper is to design a process for the development of curricula to advance social enterprise education using the lens of critical management studies (CMS). It is motivated by ongoing work to develop a new award in Cooperative Business and Responsible Management as well as ongoing work to develop the use of Understanding Social Enterprise: Theory and Practice (Ridley-Duff & Bull, 2011; 2016)

Fall Town Hall on Research Data Management

This Town Hall was held to share recommendations for Research Data Management at Western that result from a gap analysis to understand the RDM needs at Western, conducted by Athenaeum21, a strategy and technology consultancy engaged by Western for this work. The recommendations will inform the implementation of Western’s Research Data Management Strategy, which shapes Research Data Management at Western for all researchers, grant funded or not, student or faculty, regardless of discipline

Becoming-with More-than-human Protected Areas

The planet is currently undergoing immense and permanent geological change and environmental decline, a period some scholars have referred to as the Anthropocene. Climate change and environmental events, biodiversity declines, wildfires, flooding, pollution, and pandemics are changing the ways in which we engage with the natural environment – as tourist and recreationist. Protected areas, and Parks in particular, are uniquely placed within this broader context of environmental crises in Canada on account of their dual mandate to both facilitate positive visitor experiences and to conserve the ecology and heritage of a site. Tethered to these mandate positions are anthropocentric separations or distinctions between humans and nature. The first, visitor experience, positions humans as visitors and nature as the backdrop for human recreation and tourism. The second mandate, conserving ecologies and heritage, assumes that humans as managers of these places can intervene in nature for particular outcomes, reinforcing ideas of human superiority over nonhumans and nature. Framed by posthuman philosophical, theoretical, and methodological approaches, the manuscripts, book chapter, and research note comprising this thesis work individually (and in combination) to disrupt, co-opt, challenge, and attend to concepts (i.e., anthropomorphism, affective reverberations, time, and agency) that have largely been subject to anthropocentric inscription and offer productive spaces for experimenting with different kinds of affective-sensory-material attunement practices in protected areas. The specific aims of this project are to contribute to building some of the conceptual foundations necessary for a more-than-human conservation ethic and practice premised on knowing-with, being-with, and researching-with nonhumans in nature-based tourism. With the exception of the research note, each chapter also experiments with more-than-human attunements borne of (re)enchantment (i.e., care as action) with concepts, integrating posthuman relationality and praxis with (re)presentational choices intended to evoke and affect (rather than represent per se). Each article simultaneously engages theory-methodology-(re)presentation as an iterative and entangled practice of being-with more-than-human places. Specifically, this research draws upon the sensory-attunements of walking methodologies, the methodological fluidity of methodologies without methodology, and the evocativeness of nonrepresentational methodologies, as an embodied practice of attending. Situated within more-than-human encounters in three Provincial Parks in Ontario, Canada, this thesis contributes to the growing interdisciplinary scholarship engaging with nonhumans as kin and invites us to care-with more-than-human temporalities, agency, and affectivity for more inclusive, responsive, and response-able tourism futures

Distributive Justice for Volunteers: Extrinsic Outcome Distribution Matters

Volunteer organizations continue to suffer from turnover; the current volunteer rate is the lowest since 2002. Distributive justice, satisfaction, and extrinsic outcome importance were examined as influences of volunteer intention to quit. Survey results from 294 volunteers revealed that those who perceived less than fair distribution of extrinsic outcomes experienced heightened intention to quit compared to those who perceived fair distribution. Overall satisfaction partially mediated this relationship. We explored the potential moderating role of volunteers’ assessment of the importance of extrinsic outcomes on the overall mediated relationship

Developing a critical appreciative process to review frameworks for social enterprise education

The object of this paper is to design a process for the development of curricula to advance social enterprise education using the lens of critical management studies (CMS). It is motivated by ongoing work to develop a new award in Cooperative Business and Responsible Management at [University] as well as ongoing work to develop the use of Understanding Social Enterprise: Theory and Practice (Ridley-Duff & Bull, 2011; 2016). Five projects have influenced the authors’ conceptualisations of social enterprise and responsible management. In this paper, we set out the rationale for taking a critical approach to curriculum development based on critiquing a framework developed by the ARIADNE project (Moreau and Mertens, 2013). We develop an argument for comparing it to four other frameworks that have competed to shape our thinking. Whilst acknowledging the potential danger of ‘closure’ through the development of curricula that converge on normative values and principles, our goal is the development and application of a critical appreciative process that ensures any normative consensus is destabilised to ensure that new curricula acknowledge where a dissensus exists. Guided by new research on ‘critical appreciation’ that explores the interaction between social systems and personal lifeworlds, we frame ‘competencies’ as system imperatives in social enterprise education, and ‘knowledge’, ‘skills’ and ‘attitudes’ as proxies for the lifeworlds that it aims to create. The paper sets out how critical appreciation provides a process for comparing and contrasting selected frameworks to deconstruct the discourse that underpins the values and principles in each implied curriculum. This process is designed to encourage the authors to re-examine their assumptions as they co-construct a new curriculum. By designing a process for deconstructing and comparing multiple frameworks for social enterprise education, we advance CMS by enabling institutions, academics and students to: 1) reclaim choice in how they shape and develop social enterprise courses; 2) develop a theory of social enterprise education that is reflexive regarding its impact on curriculum development and which encourages andragogy over pedagogy. The value of this paper lies is the process developed for the active construction of new courses on social enterprise that embed the perspective of critical management studies in their development. The paper also offers a new application of ‘critical appreciative processes (CAPs) in the field of management education

Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption

Transcripts containing premature termination codons (PTCs) can be subject to nonsense-associated alternative splicing (NAS). Two models have been evoked to explain this, scanning and splice motif disruption. The latter postulates that exonic cis motifs, such as exonic splice enhancers (ESEs), are disrupted by nonsense mutations. We employ genome-wide transcriptomic and k-mer enrichment methods to scrutinize this model. First, we show that ESEs are prone to disruptive nonsense mutations owing to their purine richness and paucity of TGA, TAA and TAG. The motif model correctly predicts that NAS rates should be low (we estimate 5–30%) and approximately in line with estimates for the rate at which random point mutations disrupt splicing (8–20%). Further, we find that, as expected, NAS-associated PTCs are predictable from nucleotide-based machine learning approaches to predict splice disruption and, at least for pathogenic variants, are enriched in ESEs. Finally, we find that both in and out of frame mutations to TAA, TGA or TAG are associated with exon skipping. While a higher relative frequency of such skip-inducing mutations in-frame than out of frame lends some credence to the scanning model, these results reinforce the importance of considering splice motif modulation to understand the etiology of PTC-associated disease

Transcription, mRNA export, and immune evasion shape the codon usage of viruses

The nucleotide composition, dinucleotide composition, and codon usage of many viruses differ from their hosts. These differences arise because viruses are subject to unique mutation and selection pressures that do not apply to host genomes; however, the molecular mechanisms that underlie these evolutionary forces are unclear. Here, we analyzed the patterns of codon usage in 1,520 vertebrate-infecting viruses, focusing on parameters known to be under selection and associated with gene regulation. We find that GC content, dinucleotide content, and splicing and m(6)A modification-related sequence motifs are associated with the type of genetic material (DNA or RNA), strandedness, and replication compartment of viruses. In an experimental follow-up, we find that the effects of GC content on gene expression depend on whether the genetic material is delivered to the cell as DNA or mRNA, whether it is transcribed by endogenous or exogenous RNA polymerase, and whether transcription takes place in the nucleus or cytoplasm. Our results suggest that viral codon usage cannot be explained by a simple adaptation to the codon usage of the host—instead, it reflects the combination of multiple selective and mutational pressures, including the need for efficient transcription, export, and immune evasion

Developing a Critical Appreciative Process to Review Frameworks for Social Enterprise Education

Objectives The object of this paper is to design a process for the development of curricula to advance social enterprise education using the lens of critical management studies (CMS). It is motivated by ongoing work to develop a new award in Cooperative Business and Responsible Management at [University] as well as ongoing work to develop the use of Understanding Social Enterprise: Theory and Practice (Ridley-Duff & Bull, 2011; 2016)*. Prior Work Five projects have influenced the authors’ conceptualisations of social enterprise and responsible management. In this paper, we set out the rationale for taking a critical approach to curriculum development based on critiquing a framework developed by the ARIADNE project (Moreau and Mertens, 2013). We develop an argument for comparing it to four other frameworks that have competed to shape our thinking. Whilst acknowledging the potential danger of ‘closure’ through the development of curricula that converge on normative values and principles, our goal is the development and application of a critical appreciative process that ensures any normative consensus is destabilised to ensure that new curricula acknowledge where a dissensus exists. Approach Guided by new research on ‘critical appreciation’ that explores the interaction between social systems and personal lifeworlds, we frame ‘competencies’ as system imperatives in social enterprise education, and ‘knowledge’, ‘skills’ and ‘attitudes’ as proxies for the lifeworlds that it aims to create. Results The paper sets out how critical appreciation provides a process for comparing and contrasting selected frameworks to deconstruct the discourse that underpins the values and principles in each implied curriculum. This process is designed to encourage the authors to re-examine their assumptions as they co-construct a new curriculum. Implications By designing a process for deconstructing and comparing multiple frameworks for social enterprise education, we advance CMS by enabling institutions, academics and students to: 1) reclaim choice in how they shape and develop social enterprise courses; 2) develop a theory of social enterprise education that is reflexive regarding its impact on curriculum development and which encourages andragogy over pedagogy. Value The value of this paper lies is the process developed for the active construction of new courses on social enterprise that embed the perspective of critical management studies in their development. The paper also offers a new application of ‘critical appreciative processes (CAPs) in the field of management education. * The second edition will be launched at ISBE 2015 in Glasgow, November 11th – 12t

Causes and consequences of purifying selection on SARS-CoV-2

Owing to a lag between a deleterious mutation’s appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed, from analysis of closely related lineages, in SARS-CoV-2, the Ka/Ks ratio was previously estimated as 1.008, suggesting no within-host selection. By contrast, we find a higher number of observed SNPs at 4-fold degenerate sites than elsewhere and, allowing for the virus’s complex mutational and compositional biases, estimate that the mutation rate is at least 49–67% higher than would be estimated based on the rate of appearance of variants in sampled genomes. Given the high Ka/Ks one might assume that the majority of such intrahost selection is the purging of nonsense mutations. However, we estimate that selection against nonsense mutations accounts for only ∼10% of all the “missing” mutations. Instead, classical protein-level selective filters (against chemically disparate amino acids and those predicted to disrupt protein functionality) account for many missing mutations. It is less obvious why for an intracellular parasite, amino acid cost parameters, notably amino acid decay rate, is also significant. Perhaps most surprisingly, we also find evidence for real-time selection against synonymous mutations that move codon usage away from that of humans. We conclude that there is common intrahost selection on SARS-CoV-2 that acts on nonsense, missense, and possibly synonymous mutations. This has implications for methods of mutation rate estimation, for determining times to common ancestry and the potential for intrahost evolution including vaccine escape

Non-Contact Determination of Free Carrier Concentration in n-GaInAsSb

GaSb-based semiconductors are of interest for mid-infrared optoelectronic and high-speed electronic devices. Accurate determination of electrical properties is essential for optimizing the performance of these devices. However, electrical characterization of these semiconductors is not straightforward since semi-insulating (SI) GaSb substrates for Hall measurements are not available. In this work, the capability of Raman spectroscopy for determination of the majority carrier concentration in n-GaInAsSb epilayers was investigated. Raman spectroscopy offers the advantage of being non-contact and spatially resolved. Furthermore, the type of substrate used for the epilayer does not affect the measurement. However, for antimonide-based materials, traditionally employed Raman laser sources and detectors are not optimized for the analysis wavelength range dictated by the narrow band gap of these materials. Therefore, a near-infrared Raman spectroscopic system, optimized for antimonide-based materials, was developed. Ga{sub 0.85}In{sub 0.15}As{sub 0.13}Sb{sub 0.87} epilayers were grown by organometallic vapor phase epitaxy with doping levels in the range 2 to 80 x 10{sup 17} cm{sup -3}, as measured by secondary ion mass spectrometry. For a particular nominal doping level, epilayers were grown both lattice matched to n-GaSb substrates and lattice-mismatched to SI GaAs substrates under nominally identical conditions. Single magnetic field Hall measurements were performed on the epilayers grown on SI GaAs substrates, while Raman spectroscopy was used to measure the carrier concentration of epilayers grown on GaSb and the corresponding SI GaAs substrates. Compared to Hall measurements, Raman spectra indicated that the GaInAs/Sb epilayers grown on GaSb substrates have higher free carrier concentrations than the corresponding epilayers grown on SI GaAs substrates under nominally identical conditions. This is contrary to the assumption that for nominally identical growth conditions, the resulting carrier concentration is independent of substrate, and possible mechanisms will be discussed