Inflammatory Markers: C-Reactive Protein, Erythrocyte Sedimentation Rate, and Leukocyte Count in Vitamin D Deficient Patients with and without Chronic Kidney Disease

Although some studies revealed a positive relationship between vitamin D3 deficiency and inflammatory markers, there have been also many studies that failed to find this relationship. The aim of this large scaled study is to determine the association between the level of plasma 25 hydroxy vitamin D3 [25-(OH) D3] and inflammatory markers in the general population without chronic kidney disease (CKD) and in patients with CKD. Participants with simultaneously measured inflammatory markers and 25-(OH) D3 levels were retrospectively analyzed (n=1897). The incidence of all-cause inflammation infection, hospitalization, chronic renal failure, and vitamin B12 deficiency was evaluated. The medians of serum creatinine levels in subjects without renal failure were lower in 25-(OH) D3 deficient group. Patients with CKD were more likely to have vitamin D3 deficiency compared with normal GFR. 25-(OH) D3 levels were associated with a greater incidence of all-cause hospitalization, hypoalbuminemia, and vitamin B12 deficiency. However, there was no relationship between inflammatory markers and vitamin D3 levels. In 25-(OH) D3 deficient patients, inflammatory markers can be related to other inflammatory and infectious status such as malnutrition and cachexia. We believed that there must be a relationship between vitamin deficiency and inflammatory markers due to other causes than low 25-(OH) D3 status

Volume status effected by gravity and body fluid shifts: new protocol for bioimpedance measurements

WOS: 000344391400019PubMed ID: 2523849

A NEW TECHNIQUE FOR ESTABLISHING DRY WEIGHT IN HEMODIALYSIS PATIENTS VIA ESTIMATION OF PULMONARY CAPILLARY WEDGE PRESSURE. A TISSUE DOPPLER IMAGING STUDY

53rd ERA-EDTA Congress -- MAY 21-24, 2016 -- Vienna, AUSTRIAWOS: 000376653800582European Renal Assoc, European Dialysis & Transplant Asso

The effects of mycophenolate mofetil on encapsulated peritoneal sclerosis model in rats

WOS: 000299971100001PubMed ID: 22185962Introduction: Encapsulated peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis. We aimed to investigate the effects of mycophenolate mofetil (MMF) treatment in experimental EPS in rats. Methods: 40 nonuremic Wistar albino rats were divided equally into 4 groups: control rats received 2 nil isotonic saline intraperitoneally daily for 3 weeks without any other treatment. The chlorhexidine gluconate group received intraperitoneally 2 ml/200 g injection of chlorhexidine gluconate and ethanol dissolved in saline for 3 weeks. The resting group received chlorhexidine gluconate (0 - 3rd week) + peritoneal resting (4th - 6th week). The MMF group received chlorhexidine gluconate (0 - 3rd week) + 125 mg/l MMF in drinking water (4th - 6th week). Dialysate cytokine levels, leukocyte count, peritoneal thickness, inflammation and fibroblast activities were evaluated. Results: Although the MMF and resting groups showed beneficial effects on ultrafiltration and D-1/D-0 glucose compared to the chlorhexidine gluconate group, only MMF treatment improved dialysate TGF-beta 1, VEGF and MCP-1 levels compared to the resting group. Inflammatory activity and vascularity observed in a tissue biopsy, including capillaries number per mm(2) of submesothelial area, decreased in the treatment group. Conclusions: MMF treatment has beneficial effects on EPS via inhibiting inflammation and neovascularisation by reducing dialysate VEGF overexpression

EVALUATION OF ASSOCIATION BETWEEN ATHEROGENIC INDEX OF PLASMA AND INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERY FOR SUBCLINIC ATHERSCLEROSIS IN PATIENTS ON MAINTENANCE HEMODIALYSIS

50th European-Renal-Association - European-Dialysis-and-Transplant-Association Congress -- MAY 18-21, 2013 -- Istanbul, TURKEYWOS: 000319498202399European Renal Assoc (ERA), European Dialysis & Transplant Assoc (EDTA

NATIVE RENAL BIOPSIES PERFORMED IN OLDER ADULTS ARE INCREASING: TWELVE YEARS EXPERIENCE OF EGE UNIVERSITY

WOS: 000298241300002Introduction: Determination of the frequency and prevalence of biopsy proven nephropathies in older adults and adults is important for epidemiological studies. Materials and Method: Predominant glomerulonephritis (GN) in native renal biopsies of adults and older adults (>= 65 years) were evaluated. Results: Among a total of 1702 renal biopsies (males 52%, ages 16-82, mean 40 +/- 15 years), 121 (7%) were performed in persons >= 65 years old. The mean age at the time of renal biopsy increased from 37.3 +/- 16.8 in 1996 to 44 +/- 16.1 years in 2009. The leading indications for biopsy in older and younger age groups were nephrotic syndrome (NS) (46.5% vs. 39.8% respectively), asymptomatic urinary abnormalities (20.9% vs. 33.4% respectively) acute renal failure (15.1% vs. 7.4% respectively) and hematuria (4.7% vs. 10.9% respectively). The etiologies of NS were amyloidosis, membranous GN and focal segmental glomerulosclerosis (FSGS) in both age groups. Primary GN was the predominant etiology in both age groups. Above 65 years, membranous (14.8%) and crescentic (9.9%) GNs were predominant while below 65 years IgA nephropathy (9%) was predominant. Among secondary GNs, amyloidosis (19%) and lupus nephritis (11.7%) were also predominant in the elderly and the younger persons respectively. Conclusion: The current data represents the experience of a single center. Such registries will allow epidemiologic studies to answer several open questions regarding both prevention and treatment of nephropathies in different age groups

A NEW METHOD TO PREDICT SURVIVAL IN HEMODIALYSIS PATIENTS IMPEDANCE RATIO

WOS: 00046979710139

A new technique for the detection of dry weight in hemodialysis patients: Estimated pulmonary capillary wedge pressure. A tissue Doppler imaging study.

Background and objective: Fluid overload is an important factor of morbidity and mortality in hemodialysis patients. Today correct determination of dry weight (DW) remains an important issue of hemodialysis practice. Within this context, it is subjected to new method searching. The objective of this study was to calculate estimated pulmonary capillary wedge pressure (ePCWP) with Tissue Doppler Imaging (TDI) in hemodialysis patients and to evaluate its correlation with the other volume markers and to evaluate whether it can be a new method for detection of DW. Materials and methods: Echocardiographic, hemodynamic, and biochemical volume markers of 41 hemodialysis patients were evaluated in the pre- and post-dialysis periods. Patients were divided into two groups based on ePCWP values (Group 1 ePCWP 20 mmHg). Results: In the pre-dialysis period; parameters related to volume load including ePCWP, systolic blood pressure, mean arterial pressure, pulse pressure, left atrial diameter, left atrial volume, E/e, ratio and E/V-p ratio were statistically significantly higher in Gmup2 compared to Group1. On the other hand, strong correlations were found between pre-dialysis ePCWP and systolic blood pressure, mean arterial pressure, pulse pressure, NT-ProBNP, left atrial diameter, E/e ratio and E/V-p ratio. Conclusions: Strong correlations found between ePCWP which was calculated with TDI and the other volume markers both in pre-dialysis and post-dialysis periods. These findings can provide a significant contribution to routine evaluating of DW in hemodialysis patients. From this aspect, the prediction of ePCWP with TDI can be a new practical and reproducible method for the determination of DW. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U