3,206 research outputs found

    Principles of Contract Law Applied to Entertainment and Sports Contracts: A Model for Balancing the Rights of the Industry with Protecting the Interests of Minors

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    This Article discusses the context of common law and statutory materials dealing with minors who participate in the entertainment and sports fields. The Article describes the changes undertaken as a result of several notorious cases involving prominent child actors, and how the California legislature dealt with issues ranging from set asides of income, approval of contracts by a competent court of jurisdiction, recognition of the legitimate interests of all parties to the contract, to principles under which a minor would be precluded from disaffirming a contract. The Article then applies and extends the principles developed in entertainment contracts to minors who participate in professional athletics and offers concrete suggestions for perfecting a balance in interests by focusing on assuring the minor with representation by “qualified counsel experienced with entertainment industry law and practices

    Preparation and Characterization of Photoactive Antimicrobial Graphitic Carbon Nitride (g-C\u3csub\u3e3\u3c/sub\u3eN\u3csub\u3e4\u3c/sub\u3e) Films

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    Photoactive films derived from nanostructured samples of the metal-free, intermediate band gap semiconductor graphitic carbon nitride (ns-g-C3N4) have been synthesized and characterized for their particle properties and antimicrobial activity. Physical characterization reveals that these materials are composed of discrete nanoparticles whose dimensions range from 200 nm to 700 nm. Investigation of the photochemical reactivity of ns-g-C3N4 using coumarin-3- carboxylic acid (3-CCA) indicates that this material produces reactive oxygen species (ROS) under visible radiation. When irradiated with 0.31J visible light, ns-g-C3N4-based materials reduced the viability of both gram-negative Escherichia coli O157:H7 and gram-positive Staphylococcus aureus by approximately 50%. Nearly complete inactivation of both strains of microorganisms was achieved upon administration of a 0.62J dose of visible radiation. Importantly, no biocidal activity was observed for non-irradiated samples, indicating that the g-C3N4-derived films are not inherently toxic in the absence of visible light. The results of this study suggest that materials and, by extention, films and coatings derived from g-C3N4 may present a novel route for controlling pathogenic microorganisms on surfaces in the environment, and could be useful in reducing incidents of hospital-acquired infections

    Are Boredom Prone Individuals Creative and Curious About Their Environment?

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    After controlling for overall personality characteristics, boredom proneness did not predict creativity, but did positively predict people’s motivation to seek out novel experiences and find answers to things they do not understand. Thus, future work should explore how to use these relationships to help individuals respond effectively to the experience of boredom.Knowledge Mobilization at York - York University’s Knowledge Mobilization Unit provides services for faculty, graduate students, community and government seeking to maximize the impact of academic research and expertise on public policy, social programming, and professional practice. This summary has been supported by the Office of the Vice-President Research and Innovation at York and project funding from SSHRC and CIHR. [email protected] www.researchimpact.c

    In situ effects of selected preservatives on total carbon, nitrogen and metals collected in sediment traps

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    The concentration and chemical composition of preservative or poison to use in sediment trap studies continue to present an important unresolved question. Past laboratory/field experiments designed to answer this question are difficult to interpret, because so-called analogs have been used instead of actual trap materials, which are compositionally complex. This paper presents our results on the in situ effects of formalin, azide and mercuric ion on material collected in MULTITRAPS set at 100 and 300 m for a period of six days in a coastal environment, and at 150 m for a period of 20.6 days in an oligotrophic environment. Effective preservative/poison concentrations used were predetermined from laboratory tests. Parameters tested for relative effects included particulate retention of C, N and selected trace metals, and the effects of the various preservatives/poisons introduced via diffusion chambers or free in solution on in situ microbial growth. In addition, the potential contaminating role of large, nonsinking zooplankton (i.e., “swimmers”) was investigated. Substantial differences between treatments were observed. Effects were not uniform, and appeared to be parameter-specific. For example, during the short-term deployment (six days), no significant differences in C flux were observed at 100 m, regardless of preservative used. Traps treated with azide yielded significantly lower N values. At 300 m (short-term deployment), and 150 m (long-term deployment), the azide treatments produced the lowest mean C and N values. Conversely, the formalin traps gave the highest C and N values relative to all treatments at these depths. In terms of metals, \u3e70% of both Cd and Mn were lost to the trap solutions, regardless of oceanic area or time deployed, while most of the Fe tended to remain in the particulate phase. Zinc, largely in association with the particulate phase over the six-day deployment, was lost to the density solution during the 20.6-day deployment, while Pb results were intermediate between these extremes. Results of the diffusion chamber experiment indicate that the formalin and mercuric ion treatments were equally effective regardless of the mode of introduction (i.e., diffusion chamber or free in solution). Azide did not appear as effective when introduced via diffusion

    A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-Îł for Autoreactive CD8+CD8^+ T Cell Accumulation in the Skin

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    Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting in part limited knowledge of disease pathogenesis. Existing mouse models of vitiligo consist of hair depigmentation but lack prominent epidermal involvement, which is the hallmark of human disease. They are thus unable to provide a platform to fully investigate disease mechanisms and treatment. CD8+CD8^+ T cells have been implicated in the pathogenesis of vitiligo and expression of interferon-gamma (IFN-Îł) is increased in the lesional skin of patients, however it is currently unknown what role IFN-Îł plays in disease. Here, we have developed an adoptive transfer mouse model of vitiligo using melanocyte-specific CD8+CD8^+ T cells, which recapitulates the human condition by inducing epidermal depigmentation while sparing the hair. Like active lesions in human vitiligo, histology of depigmenting skin reveals a patchy mononuclear infiltrate and single-cell infiltration of the epidermis. Depigmentation is accompanied by accumulation of autoreactive CD8+CD8^+ T cells in the skin, quantifiable loss of tyrosinase transcript, and local IFN-Îł production. Neutralization of IFN-Îł with antibody prevents CD8+CD8^+ T cell accumulation and depigmentation, suggesting a therapeutic potential for this approach

    Employment Testing and Incentives to Learn

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    Employment tests predict job performance because they measure or are correlated with a large set of malleable developed abilities which are causally related to productivity. Our economy currently under-rewards the achievements that are measured by these tests. Consequently, economic incentives to study hard in high school are minimal and this absence of incentives has contributed to the low levels of achievement in math and science. The paper concludes with a discussion of ways in which employment tests can strengthen incentives to learn

    Generalized LĂ©vy walks and the role of chemokines in migration of effector CD8+ T cells.

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    Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effector T-cell population in the brain and speeds up the average migration speed without changing the nature of the walk statistics. Notably, these statistics are not Brownian; rather, CD8+ T-cell motility in the brain is well described by a generalized LĂ©vy walk. According to our model, this unexpected feature enables T cells to find rare targets with more than an order of magnitude more efficiency than Brownian random walkers. Thus, CD8+ T-cell behaviour is similar to LĂ©vy strategies reported in organisms ranging from mussels to marine predators and monkeys, and CXCL10 aids T cells in shortening the average time taken to find rare targets

    Australian vegetation classification and the International Vegetation Classification framework: an overview with case studies

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    Recent advances in conceptual frameworks in vegetation classifications, such as the EcoVeg approach that underpins the International Vegetation Classification (IVC) developed by NatureServe staff and colleagues, offer opportunities to enhance national classification initiatives. National level initiatives provide an important stepping-stone between international units and subnational units. Australia has a long history of developing various vegetation typologies at local to regional scales, but ecologists recognise the need for an Australia-wide, plot-based vegetation classification system that incorporates the principles of the EcoVeg approach, and thereby helps build an international classification system. Using two case studies, we provide a comparison of various structures and criteria for relevant Australian classifications in the context of the IVC, and exemplify how Australian classifications of forest, shrublands, grasslands, and deserts could potentially link into the IVC hierarchy to illustrate the capacity of the IVC to summarise the full range of Australian vegetation at a broad formation (biome) scale. We then discuss how the IVC might inform future work towards an Australian vegetation classification system and, vice versa, the implications of an Australian vegetation classification for IVC development
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