Optical Selection of Galaxies at Redshifts 1<z<3

Few galaxies have been found between the redshift ranges z < ~1 probed by magnitude-limited surveys and z > ~3 probed by Lyman-break surveys. Comparison of galaxy samples at lower and higher redshift suggests that large numbers of stars were born and the Hubble sequence began to take shape at the intermediate redshifts 1<z<3, but observational challenges have prevented us from observing the process in much detail. We present simple and efficient strategies that can be used to find large numbers of galaxies throughout this important but unexplored redshift range. All the strategies are based on selecting galaxies for spectroscopy on the basis of their colors in ground-based images taken through a small number of optical filters: GRi for redshifts 0.85<z<1.15, GRz for 1<z<1.5, and UGR for 1.4<z<2.1 and 1.9<z<2.7. The performance of our strategies is quantified empirically through spectroscopy of more than 2000 galaxies at 1<z<3.5. We estimate that more than half of the UV-luminosity density at 1<z<3 is produced by galaxies that satisfy our color-selection criteria. Our methodology is described in detail, allowing readers to devise analogous selection criteria for other optical filter sets.Comment: 13 pages including 20 figures. Accepted for publication in the Ap

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A Survey of Star-Forming Galaxies in the z=1.4-2.5 `Redshift Desert': Overview

We present the first results of a large-scale survey, using the UV/blue sensitive LRIS-B spectrograph on the Keck I telescope, of galaxies in the redshift interval 1.4<z<2.5, often called the `redshift desert' because of historical difficulties in spectroscopically identifying galaxies in that range. We introduce two samples of star forming galaxies, `BX' galaxies at =2.20+/-0.32 and `BM' galaxies at =1.70+/-0.34; currently we have spectroscopically confirmed 749 of the former and 114 of the latter. We also present initial results of deep near-IR photometry and spectroscopy, from which we show that z~2 galaxies are significantly redder in their optical/IR colors compared to similarly UV-selected galaxies at z~3, but that the characteristics of their galaxy-scale outflows are quite similar. We illustrate by example the information which can be deduced on the stellar populations, metallicities, and kinematics of `redshift desert' galaxies from easily accessible rest-frame far-UV and rest-frame optical spectra. Far from being hostile to observations, the universe at z~2 is uniquely suited to providing information on the astrophysics of star-forming galaxies and the intergalactic medium, and the relationship between the two [abridged].Comment: To appear in ApJ, April 2004. 16 pages, uses emulateap

TGF-β1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells

The optimal medium for cardiac differentiation of adult primitive cells remains to be established. We quantitatively compared the efficacy of IGF-1, dynorphin B, insulin, oxytocin, bFGF, and TGF-beta1 in inducing cardiomyogenic differentiation. Adult mouse skeletal muscle-derived Sca1+/CD45-/c-kit-/Thy-1+ (SM+) and Sca1-/CD45-/c-kit-/Thy-1+ (SM-) cells were cultured in basic medium (BM; DMEM, FBS, IGF-1, dynorphin B) alone and BM supplemented with insulin, oxytocin, bFGF, or TGF-beta1. Cardiac differentiation was evaluated by the expression of cardiac-specific markers at the mRNA (qRT-PCR) and protein (immunocytochemistry) levels. BM+TGF-beta1 upregulated mRNA expression of Nkx2.5 and GATA-4 after 4 days and Myl2 after 9 days. After 30 days, BM+TGF-beta1 induced the greatest extent of cardiac differentiation (by morphology and expression of cardiac markers) in SM- cells. We conclude that TGF-beta1 enhances cardiomyogenic differentiation in skeletal muscle-derived adult primitive cells. This strategy may be utilized to induce cardiac differentiation as well as to examine the cardiomyogenic potential of adult tissue-derived stem/progenitor cells

Hockey Fans in Training: A Pilot Pragmatic Randomized Controlled Trial

Introduction&nbsp; Hockey Fans in Training (Hockey FIT) is a gender-sensitized weight loss and healthy lifestyle program. We investigated 1) feasibility of recruiting and retaining overweight and obese men into a pilot pragmatic randomized controlled trial and 2) potential for Hockey FIT to lead to weight loss and improvements in other outcomes at 12 wk and 12 months.&nbsp; Methods&nbsp; Male fans of two ice hockey teams (35-65 yr; body mass index &ge;28 kg&middot;m-2) located in Ontario (Canada) were randomized to intervention (Hockey FIT) or comparator (wait-list control). Hockey FIT includes a 12-wk active phase (weekly, coach-led group meetings including provision of dietary information, practice of behavior change techniques, and safe exercise sessions plus incremental pedometer walking) and a 40-wk minimally supported phase (smartphone app for sustaining physical activity, private online social network, standardized e-mails, booster session/reunion). Measurement at baseline and 12 wk (both groups) and 12 months (intervention group only) included clinical outcomes (e.g., weight) and self-reported physical activity, diet, and self-rated health.&nbsp; Results&nbsp; Eighty men were recruited in 4 wk; trial retention was &gt;80% at 12 wk and &gt;75% at 12 months. At 12 wk, the intervention group lost 3.6 kg (95% confidence interval, -5.26 to -1.90 kg) more than the comparator group (P &lt; 0.001) and maintained this weight loss to 12 months. The intervention group also demonstrated greater improvements in other clinical measures, physical activity, diet, and self-rated health at 12 wk; most sustained to 12 months.&nbsp; Conclusions&nbsp; Results suggest feasible recruitment/retention of overweight and obese men in the Hockey FIT program. Results provide evidence for the potential effectiveness of Hockey FIT for weight loss and improved health in at-risk men and, thus, evidence to proceed with a definitive trial

Hockey Fans in Training: A Pilot Pragmatic 1 Randomized Controlled Trial

Introduction Hockey Fans in Training (Hockey FIT) is a gender-sensitized weight loss and healthy lifestyle program. We investigated 1) feasibility of recruiting and retaining overweight and obese men into a pilot pragmatic randomized controlled trial and 2) potential for Hockey FIT to lead to weight loss and improvements in other outcomes at 12 wk and 12 months. Methods Male fans of two ice hockey teams (35–65 yr; body mass index ≥28 kg·m−2) located in Ontario (Canada) were randomized to intervention (Hockey FIT) or comparator (wait-list control). Hockey FIT includes a 12-wk active phase (weekly, coach-led group meetings including provision of dietary information, practice of behavior change techniques, and safe exercise sessions plus incremental pedometer walking) and a 40-wk minimally supported phase (smartphone app for sustaining physical activity, private online social network, standardized e-mails, booster session/reunion). Measurement at baseline and 12 wk (both groups) and 12 months (intervention group only) included clinical outcomes (e.g., weight) and self-reported physical activity, diet, and self-rated health. Results Eighty men were recruited in 4 wk; trial retention was \u3e80% at 12 wk and \u3e75% at 12 months. At 12 wk, the intervention group lost 3.6 kg (95% confidence interval, −5.26 to −1.90 kg) more than the comparator group (P \u3c 0.001) and maintained this weight loss to 12 months. The intervention group also demonstrated greater improvements in other clinical measures, physical activity, diet, and self-rated health at 12 wk; most sustained to 12 months. Conclusions Results suggest feasible recruitment/retention of overweight and obese men in the Hockey FIT program. Results provide evidence for the potential effectiveness of Hockey FIT for weight loss and improved health in at-risk men and, thus, evidence to proceed with a definitive trial

Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration

AIM: To evaluate pretreatment hepatitis B virus (HBV) testing, vaccination, and antiviral treatment rates in Veterans Affairs patients receiving anti-CD20 Ab for quality improvement. METHODS: We performed a retrospective cohort study using a national repository of Veterans Health Administration (VHA) electronic health record data. We identified all patients receiving anti-CD20 Ab treatment (2002-2014). We ascertained patient demographics, laboratory results, HBV vaccination status (from vaccination records), pharmacy data, and vital status. The high risk period for HBV reactivation is during anti-CD20 Ab treatment and 12 mo follow up. Therefore, we analyzed those who were followed to death or for at least 12 mo after completing anti-CD20 Ab. Pretreatment serologic tests were used to categorize chronic HBV (hepatitis B surface antigen positive or HBsAg+), past HBV (HBsAg-, hepatitis B core antibody positive or HBcAb+), resolved HBV (HBsAg-, HBcAb+, hepatitis B surface antibody positive or HBsAb+), likely prior vaccination (isolated HBsAb+), HBV negative (HBsAg-, HBcAb-), or unknown. Acute hepatitis B was defined by the appearance of HBsAg+ in the high risk period in patients who were pretreatment HBV negative. We assessed HBV antiviral treatment and the incidence of hepatitis, liver failure, and death during the high risk period. Cumulative hepatitis, liver failure, and death after anti-CD20 Ab initiation were compared by HBV disease categories and differences compared using the χ2 test. Mean time to hepatitis peak alanine aminotransferase, liver failure, and death relative to anti-CD20 Ab administration and follow-up were also compared by HBV disease group. RESULTS: Among 19304 VHA patients who received anti-CD20 Ab, 10224 (53%) had pretreatment HBsAg testing during the study period, with 49% and 43% tested for HBsAg and HBcAb, respectively within 6 mo pretreatment in 2014. Of those tested, 2% (167/10224) had chronic HBV, 4% (326/7903) past HBV, 5% (427/8110) resolved HBV, 8% (628/8110) likely prior HBV vaccination, and 76% (6022/7903) were HBV negative. In those with chronic HBV infection, ≤ 37% received HBV antiviral treatment during the high risk period while 21% to 23% of those with past or resolved HBV, respectively, received HBV antiviral treatment. During and 12 mo after anti-CD20 Ab, the rate of hepatitis was significantly greater in those HBV positive vs negative (P = 0.001). The mortality rate was 35%-40% in chronic or past hepatitis B and 26%-31% in hepatitis B negative. In those pretreatment HBV negative, 16 (0.3%) developed acute hepatitis B of 4947 tested during anti-CD20Ab treatment and follow-up. CONCLUSION: While HBV testing of Veterans has increased prior to anti-CD20 Ab, few HBV+ patients received HBV antivirals, suggesting electronic health record algorithms may enhance health outcomes

H-alpha Spectroscopy of Galaxies at z>2: Kinematics and Star Formation

We present near-infrared spectroscopy of H-alpha emission lines in a sample of 16 star-forming galaxies at redshifts 2.0<z<2.6. Our targets are drawn from a large sample of galaxies photometrically selected and spectroscopically confirmed to lie in this redshift range. Six of the galaxies exhibit spatially extended, tilted H-alpha emission lines; rotation curves for these objects reach mean velocities of ~150 km/s at radii of ~6 kpc, without corrections for any observational effects. The velocities and radii give a mean dynamical mass of M>4e10 M_sun. One-dimensional velocity dispersions for the 16 galaxies range from ~50 to ~260 km/s, and in cases where we have both virial masses implied by the velocity dispersions and dynamical masses derived from the spatially extended emission lines, they are in rough agreement. We compare our kinematic results to similar measurements made at z~3, and find that both the observed rotational velocities and velocity dispersions tend to be larger at z~2 than at z~3. We find a mean SFR_H-alpha of 16 M_sun/yr and an average SFR_H-alpha/SFR_UV ratio of 2.4, without correcting for extinction. We see moderate evidence for an inverse correlation between the UV continuum luminosity and the ratio SFR_H-alpha/SFR_UV, such as might be observed if the UV-faint galaxies suffered greater extinction. We discuss the effects of dust and star formation history on the SFRs, and conclude that extinction is the most likely explanation for the discrepancy between the two SFRs.Comment: 20 pages, 9 figures. Accepted by Ap

Hockey Fans in Training (Hockey FIT) Pilot Study Protocol: A Gender-Sensitized Weight Loss and Healthy Lifestyle Program for Overweight and Obese Male Hockey Fans

Background: Effective approaches that engage men in weight loss and lifestyle change are important because of worldwide increases, including in Canada, in obesity and chronic diseases. Football Fans in Training (FFIT), developed in Scotland, successfully tackled these problems by engaging overweight/obese male football fans in sustained weight loss and positive health behaviours, through program deliveries at professional football stadia. Methods: Aims: 1) Adapt FFIT to hockey within the Canadian context and integrate with HealtheSteps™ (evidence-based lifestyle program) to develop Hockey Fans in Training (Hockey FIT); 2) Explore potential for Hockey FIT to help overweight/obese men lose weight and improve other outcomes by 12 weeks, and retain these improvements to 12 months; 3) Evaluate feasibility of recruiting and retaining overweight/obese men; 4) Evaluate acceptability of Hockey FIT; and 5) Conduct program optimization via a process evaluation. We conducted a two-arm pilot pragmatic randomized controlled trial (pRCT) whereby 80 overweight/obese male hockey fans (35–65 years; body-mass index ≥28 kg/m2 ) were recruited through their connection to two junior A hockey teams (London and Sarnia, ON) and randomized to Intervention (Hockey FIT) or Comparator (Wait-List Control). Hockey FIT includes a 12-week Active Phase (classroom instruction and exercise sessions delivered weekly by trained coaches) and a 40-week Maintenance Phase. Data collected at baseline and 12 weeks (both groups), and 12 months (Intervention only), will inform evaluation of the potential of Hockey FIT to help men lose weight and improve other health outcomes. Feasibility and acceptability will be assessed using data from self-reports at screening and baseline, program fidelity (program observations and coach reflections), participant focus group discussions, coach interviews, as well as program questionnaires and interviews with participants. This information will be analyzed to inform program optimization. Discussion: Hockey FIT is a gender-sensitive program designed to engage overweight/obese male hockey fans to improve physical activity and healthy eating choices, thereby leading to weight loss and other positive changes in health outcomes. We expect this study to provide evidence for a full-scale confirmatory pRCT. Trial registration: NCT02396524 (Clinicaltrials.gov). Date of registration: Feb 26, 2015