Theory of Polaron Resonance in Quantum Dots and Quantum-Dot Molecules

The theory of exciton coupling to photons and LO phonons in quantum dots (QDs) and quantum-dot molecules (QDMs) is presented. Resonant-round trips of the exciton between the ground (bright) and excited (dark or bright) states mediated by the LO-phonon alter the decay time and yield the Rabi oscillation. The initial distributions of the population in the ground and the excited states dominate the oscillating amplitude and frequency. This property provides a detectable signature to the information stored in a qubit made from QD or QDM for a wide range of temperature T. Our results presented herein provide an explanation to the anomaly on T-dependent decay in self-assembled InGaAs/GaAs QDMs recently reported by experiment.Comment: 30 pages, 8 figure

A new mechanism for a naturally small Dirac neutrino mass

A mechanism is proposed in which a right-handed neutrino zero mode and a right-handed charged lepton zero mode can be localized at the same place along an extra compact dimension while having markedly different spreads in their wave functions: a relatively narrow one for the neutrino and a rather broad one for the charged lepton. In their overlaps with the wave function for the left-handed zero modes, this mechanism could produce a natural large hierarchy in the effective Yukawa couplings in four dimensions, and hence a large disparity in masses.Comment: 6 pages (2 with figures), twocolumn forma

String Creation, D-branes and Effective Field Theory

This paper addresses several unsettled issues associated with string creation in systems of orthogonal Dp-D(8-p) branes. The interaction between the branes can be understood either from the closed string or open string picture. In the closed string picture it has been noted that the DBI action fails to capture an extra RR exchange between the branes. We demonstrate how this problem persists upon lifting to M-theory. These D-brane systems are analysed in the closed string picture by using gauge-fixed boundary states in a non-standard lightcone gauge, in which RR exchange can be analysed precisely. The missing piece in the DBI action also manifests itself in the open string picture as a mismatch between the Coleman-Weinberg potential obtained from the effective field theory and the corresponding open string calculation. We show that this difference can be reconciled by taking into account the superghosts in the (0+1)effective theory of the chiral fermion, that arises from gauge fixing the spontaneously broken world-line local supersymmetries.Comment: 33 page

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.

Casitas B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is important for non-small-cell lung cancer (NSCLC). We investigated if MET is a target of CBL and if enhanced in CBL-altered NSCLC. We showed that CBL wildtype cells have lower MET expression than CBL mutant cells. Ubiquitination of MET was also decreased in CBL mutant cells compared to wildtype cells. Mutant cells were also more sensitive to MET inhibitor SU11274 than wild-type cells. sh-RNA-mediated knockdown of CBL enhanced cell motility and colony formation in NSCLC cells, and these activities were inhibited by SU11274. Assessment of the phospho-kinome showed decreased phosphorylation of pathways involving MET, paxillin, EPHA2, and VEGFR. When CBL was knocked down in the mutant cell line H1975 (erlotinib-resistant), it became sensitive to MET inhibition. Our findings suggest that CBL status is a potential positive indicator for MET-targeted therapeutics in NSCLC

On Neutrino Masses and Family Replication

The old issue of why there are more than one family of quarks and leptons is reinvestigated with an eye towards the use of anomaly as a tool for constraining the number of families. It is found that, by assuming the existence of right-handed neutrinos (which would imply that neutrinos will have a mass) and a new chiral SU(2) gauge theory, strong constraints on the number of families can be obtained. In addition, a model, based on that extra SU(2), is constructed where it is natural to have one "very heavy" fourth neutrino and three almost degenerate light neutrinos whose masses are all of the Dirac type.Comment: RevTex, 12 pages with 1 figure, minor changes to the text and added acknowledgment

Precision cancer monitoring using a novel, fully integrated, microfluidic array partitioning digital PCR platform.

A novel digital PCR (dPCR) platform combining off-the-shelf reagents, a micro-molded plastic microfluidic consumable with a fully integrated single dPCR instrument was developed to address the needs for routine clinical diagnostics. This new platform offers a simplified workflow that enables: rapid time-to-answer; low potential for cross contamination; minimal sample waste; all within a single integrated instrument. Here we showcase the capability of this fully integrated platform to detect and quantify non-small cell lung carcinoma (NSCLC) rare genetic mutants (EGFR T790M) with precision cell-free DNA (cfDNA) standards. Next, we validated the platform with an established chronic myeloid leukemia (CML) fusion gene (BCR-ABL1) assay down to 0.01% mutant allele frequency to highlight the platform's utility for precision cancer monitoring. Thirdly, using a juvenile myelomonocytic leukemia (JMML) patient-specific assay we demonstrate the ability to precisely track an individual cancer patient's response to therapy and show the patient's achievement of complete molecular remission. These three applications highlight the flexibility and utility of this novel fully integrated dPCR platform that has the potential to transform personalized medicine for cancer recurrence monitoring

Supply chain security certification and operational performance:The role of upstream complexity

Supply chain security (SCS) incidents increasingly cause financial losses to manufacturing facilities and logistics service providers. Thus, supply chain security certification can have implications for production economics, particularly for importing firms who rely on a smooth logistics flow across country borders. However, it largely remains unknown regarding how such certification could influence a firm's operational performance. To this end, we empirically examine whether and how the adoption of Customs-Trade Partnership Against Terrorism (C-TPAT) certification, initiated by the U.S. Customs and Border Protection (CBP), could improve operational performance in adopter firms. This study draws upon signaling theory to empirically investigate the value of C-TPAT certification on U.S. publicly-traded importer firms' operational performance by analyzing the longitudinal data of properly-matched sample-control groups. The data come from multiple sources: public announcements of C-TPAT certification from the News Retrieval Service database, import data from lading records, and financial data from Standard & Poor's COMPUSTAT database. Employing a coarsened exact matching (CEM) method and a difference-in-difference (DID) analysis, we find that C-TPAT certified importers have better operational performance than that of non-certified importers. We also find that the level of upstream supply chain complexity (detail, dynamic, and spatial complexity) enhances the operational performance derived from C-TPAT certification. This study sheds light on the performance value of a management standard that is attributed to the non-process mechanism (not due to process improvements) enabled by the signaling effectiveness incorporating the upstream supply chain complexities. Our findings have important theoretical and practical implications for production economics and supply chain management studies

Entropy production and equilibration in Yang-Mills quantum mechanics

The Husimi distribution provides for a coarse grained representation of the phase space distribution of a quantum system, which may be used to track the growth of entropy of the system. We present a general and systematic method of solving the Husimi equation of motion for an isolated quantum system, and we construct a coarse grained Hamiltonian whose expectation value is exactly conserved. As an application, we numerically solve the Husimi equation of motion for two-dimensional Yang-Mills quantum mechanics (the x-y model) and calculate the time evolution of the coarse grained entropy of a highly excited state. We show that the coarse grained entropy saturates to a value that coincides with the microcanonical entropy corresponding to the energy of the system.Comment: 23 pages, 23 figure

Structure of the response regulator VicR DNA-binding domain

The structure of the DNA-binding domain of the response regulator VicR from E. faecalis has been solved at 1.9 Å resolution. It is very similar to the related domains from PhoB and OmpR, but differs in two loops that may affect transcription activation or DNA–protein interactions

Hydrodynamics near the QCD Phase Transition: Looking for the Longest-Lived Fireball

We propose a new strategy for the experimental search of the QCD phase transition in heavy ion collisions: One may tune collision energy around the point where the lifetime of the fireball is expected to be longest. We demonstrate that the hydrodynamic evolution of excited nuclear matter does change dramatically as the initial energy density goes through the "softest point" (where the pressure to energy density ratio reaches its minimum). For our choice of equation of state, this corresponds to epsilon_i approx. = 1.5 GeV/fm^3 and collision energy E_lab/A approx. = 30 GeV (for Au+Au). Various observables seem to show distinct changes near the softest point.Comment: 7 pages, 3 Postscript figures (tar compressed and uuencoded) submitte