3,740 research outputs found
High-Mobility Pentacene-Based Thin-Film Transistors With a Solution-Processed Barium Titanate Insulator
Abstract—Pentacene-based organic thin-film transistors
(OTFTs) with solution-processed barium titanate (Ba1.2Ti0.8O3)
as a gate insulator are demonstrated. The electrical properties
of pentacene-based TFTs show a high field-effect mobility of
8.85 cm2 · V−1 · s−1, a low threshold voltage of −1.89 V, and a
low subthreshold slope swing of 310 mV/decade. The chemical
composition and binding energy of solution-processed barium
titanate thin films are analyzed through X-ray photoelectron
spectroscopy. The matching surface energy on the surface of
the barium titanate thin film is 43.12 mJ · m−2, which leads to
Stranski–Krastanov mode growth, and thus, high mobility is
exhibited in pentacene-based TFTs.
Index Terms—Barium titanate, high field-effect mobility, high
permittivity, organic thin-filmtransistor (OTFT), solution process
Recommended from our members
Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers. A few studies have shown the involvement of FUT1 substrates in tumor cell proliferation and migration. Lysosome-associated membrane protein 1, LAMP-1, has been reported to carry alpha1,2-fucosylated Lewis Y (LeY) antigens in breast cancer cells, however, the biological functions of LeY on LAMP-1 remain largely unknown. Whether or not its family member, LAMP-2, displays similar modifications and functions as LAMP-1 has not yet been addressed. In this study, we have presented evidence supporting that both LAMP-1 and 2 are substrates for FUT1, but not FUT2. We have also demonstrated the presence of H2 and LeY antigens on LAMP-1 by a targeted nanoLC-MS(3) and the decreased levels of fucosylation on LAMP-2 by MALDI-TOF analysis upon FUT1 knockdown. In addition, we found that the expression of LeY was substantial in less invasive ER+/PR+/HER- breast cancer cells (MCF-7 and T47D) but negligible in highly invasive triple-negative MDA-MB-231 cells, of which LeY levels were correlated with the levels of LeY carried by LAMP-1 and 2. Intriguingly, we also observed a striking change in the subcellular localization of lysosomes upon FUT1 knockdown from peripheral distribution of LAMP-1 and 2 to a preferential perinuclear accumulation. Besides that, knockdown of FUT1 led to an increased rate of autophagic flux along with diminished activity of mammalian target of rapamycin complex 1 (mTORC1) and enhanced autophagosome-lysosome fusion. This may be associated with the predominantly perinuclear distribution of lysosomes mediated by FUT1 knockdown as lysosomal positioning has been reported to regulate mTOR activity and autophagy. Taken together, our results suggest that downregulation of FUT1, which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation
Optical transitions between Landau levels: AA-stacked bilayer graphene
The low-frequency optical excitations of AA-stacked bilayer graphene are
investigated by the tight-binding model. Two groups of asymmetric LLs lead to
two kinds of absorption peaks resulting from only intragroup excitations. Each
absorption peak obeys a single selection rule similar to that of monolayer
graphene. The excitation channel of each peak is changed as the field strength
approaches a critical strength. This alteration of the excitation channel is
strongly related to the setting of the Fermi level. The peculiar optical
properties can be attributed to the characteristics of the LL wave functions of
the two LL groups. A detailed comparison of optical properties between
AA-stacked and AB-stacked bilayer graphenes is also offered. The compared
results demonstrate that the optical properties are strongly dominated by the
stacking symmetry. Furthermore, the presented results may be used to
discriminate AABG from MG, which can be hardly done by STM
Locoregional therapy in luminal-like and HER2-enriched patients with de novo stage IV breast cancer
- …