Methanol extract from Vietnamese Caesalpinia sappan induces apoptosis in HeLa cells

BACKGROUND: This study evaluated the cytotoxic activity of extracts from Caesalpinia sappan heartwood against multiple cancer cell lines using an MTT cell viability assay. The cell death though induction of apoptosis was as indicated by DNA fragmentation and caspase-3 enzyme activation. RESULTS: A methanol extract from C. sappan (MECS) showed cytotoxic activity against several of the cancer cell lines. The most potent activity exhibited by the MECS was against HeLa cells with an IC50value of 26.5 ± 3.2 µg/mL. Treatment of HeLa cells with various MECS concentrations resulted in growth inhibition and induction of apoptosis, as indicated by DNA fragmentation and caspase-3 enzyme activation. CONCLUSION: This study is the first report of the anticancer properties of the heartwood of C. sappan native to Vietnam. Our findings demonstrate that C. sappan heartwood may have beneficial applications in the field of anticancer drug discovery

The problem of longitudinal shock of two spherical end elastic bars with visco-elastic resistance force

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Automatic limit and shakedown analysis of 3-D steel frames

This paper presents an efficient algorithm for both limit and shakedown analysis of 3-D steel frames by kinematical method using linear programming technique. Several features in the application of linear programming for rigid-plastic analysis of three-dimensional steel frames are discussed, as: change of the variables, automatic choice of the initial basic matrix for the simplex algorithm, direct calculation of the dual variables by primal-dual technique. Some numerical examples are presented to demonstrate the robustness, efficiency of the proposed technique and computer program

The Influence Of Human Resource Policy On Job Satisfaction In Predicting Organizational Commitment

Purpose:  This research aims to explore the relationship among  human resource policy, job  satisfaction and  organizational commitment  through  the perception of employees working in small and medium enterprises in Vietnam.   Theoretical framework: The human resource functions and related distinct processes that help attract, develop, and retain a company's human resources. They involve employees and guide them to help carry out activities aimed at achieving organizational goals employees (Jahanian et al., 2012).  Business leaders are always cautious when reviewing existing human resource policies and constantly improving to make employees satisfied with their jobs, thereby helping them improve their productivity and commitment to the organization.    Design/methodology/approach:   The qualitative method is based on an overview of previous studies, the research team builds the first scale, then the questionnaire is sent to the experts and conducts a trial survey with 30 employees to control the survey, edit and complete the concepts of the questionnaire. For the quantitative research, data was collected using convenience sampling method from a total of 400 employees and managers who are working at SMEs in Viet Nam. The method of  and Confirmatory Factor Analysis (CFA),  Structural Equation Modeling (SEM) were carried out to measure the influence of latent variables on  organizational commitment.   Findings:  The research results show that employees' perceptions of HR policies include selection and recruitment; training and improvement; evaluation of employees’ tasks; stability and promotion in work, remuneration and reward, and encouragement of participation and innovation.  These HR policies have a direct positive impact on job satisfaction and commitment to the organization. In addition, job satisfaction has a significant positive effect on organizational commitment. Therefore, it is necessary to improve the implementation of HR policies to promote employee job satisfaction, which helps to increase commitment to the organization.    Research, Practical & Social implications:  We recommend future research that expands on other components for a comprehensive assessment of HR policies. In addition, it is necessary to analyze in detail the components of organizational commitment such as affective commitment,  Continuance commitment, Normative commitment.   Originality/value: The results of standardized estimation of the parameters of the research model show that the relationship between the concepts in the formal research model is statistically significant (p<0.05). HR policies have been shown to have the most positive impact on job satisfaction in SMEs.&nbsp

Protograph LDPC Code Design For LS-MIMO 1-bit ADC Systems

Recently, two emerging research topics are protograph low-density parity-check (P-LDPC) and large-scale multi-input multi-output (LS-MIMO) with low-resolution analog-to-digital (ADC) converters (LS-MIMO-LOW-ADC). In these directions, many research works have proposed 1-bit ADC as a good candidate for LS-MIMO systems in order to save both transmission power and circuit energy dissipation. However, we observed that previously reported P-LDPC codes might not have good performance for LS-MIMO systems with 1-bit ADC. Hence, we perform a re-design of the P-LDPC codes for the above systems in this paper. The new codes demonstrate a good coding gain from 0:3 dB at rate 1/2 to 0:5 dB at rate 2/3 in different LS-MIMO configurations with 1-bit ADC

Asymptotic Analysis for the Generalized Langevin Equation with Singular Potentials

We consider a system of interacting particles governed by the generalized Langevin equation (GLE) in the presence of external confining potentials, singular repulsive forces, as well as memory kernels. Using a Mori–Zwanzig approach, we represent the system by a class of Markovian dynamics. Under a general set of conditions on the nonlinearities, we study the large-time asymptotics of the multi-particle Markovian GLEs. We show that the system is always exponentially attractive toward the unique invariant Gibbs probability measure. The proof relies on a novel construction of Lyapunov functions. We then establish the validity of the small-mass approximation for the solutions by an appropriate equation on any finite-time window. Important examples of singular potentials in our results include the Lennard–Jones and Coulomb functions