Spectral properties of XRBs in dusty early-type galaxies

We present spectral properties of a total of 996 discrete X-ray sources resolved in a sample of 23 dusty early-type galaxies selected from different environments. The combined X-ray luminosity function of all the 996 sources within the optical \D of the sample galaxies is well described by a broken power law with a break at 2.71$\times$\te \lum and is close to the Eddington limit for a 1.4\Msun neutron star. Out of the 996, about 63\p of the sources have their X-ray luminosities in the range between few\tim\ts to 2.0 \tim \tn \lum and are like normal LMXBs; about 15-20\p with luminosities $<$ few \tim 10$^{37}$ \lum are either super-soft or very-soft sources; while the remainder represents ULXs, HMXBs or unrelated heavily absorbed harder sources. More XRBs have been detected in the galaxies from isolated regions while those from rich groups and clusters host very few sources. The X-ray color-color plot for these sources has enabled us to classify them as SNRs, LMXBs, HMXBs and heavily absorbed AGNs. The composite X-ray spectra of the resolved sources within \D region of each of the galaxies are best represented by a power law with the average photon spectral index close to 1.65. The contribution of the resolved sources to the total X-ray luminosity of their host is found to vary greatly, in the sense that, in galaxies like NGC 3379 the XRB contribution is about 81\p while for NGC 5846 it is only 2\p. A correlation has been evidenced between the cumulative X-ray luminosity of the resolved sources against the star formation rate and the Ks band luminosity of the target galaxies indicating their primordial origin.Comment: 15 Pages, 6 Figures & 2 Tables, Accepted for publication in New Astronom

Customer emotions in service failure and recovery encounters

Emotions play a significant role in the workplace, and considerable attention has been given to the study of employee emotions. Customers also play a central function in organizations, but much less is known about customer emotions. This chapter reviews the growing literature on customer emotions in employee–customer interfaces with a focus on service failure and recovery encounters, where emotions are heightened. It highlights emerging themes and key findings, addresses the measurement, modeling, and management of customer emotions, and identifies future research streams. Attention is given to emotional contagion, relationships between affective and cognitive processes, customer anger, customer rage, and individual differences

Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years

Bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. Only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. We collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to test genomic alterations typically found in bladder cancer. Tumours of 118 early-onset patients were compared with a consecutive group of 113 cases. Immunohistochemistry of TP53, CK20 and Ki-67 was carried out. Molecular analysis was conducted to test for loss of heterozygosity of chromosome 9 and 17, as well as TP53 and FGFR3 mutations. Fisheŕs exact and chi-squared test were appropriately used. No differences in grade/stage characteristics were observed. Overexpressed TP53 was differentially distributed between the two groups. TP53 nuclear accumulation was significantly more frequent in early-onset papillomas, PUNLMPs and pTa low-grade tumours compared to the consecutive cohort (p=0.005). Moreover, chromosome 9 deletions (29.5% vs. 44.6%) and FGFR3 mutations (34.5% vs. 63.7%) were less often detected in early-onset patients (p=0.05 and p<0.0001). By comparing the largest cohort of early-onset bladder cancer patients with an unselected group, we demonstrated that the typical molecular features are not independent of age at diagnosis. Our study supports the hypothesis of a distinct biological behaviour in early-onset tumours

A review of diagnostic and functional imaging in headache

The neuroimaging of headache patients has revolutionised our understanding of the pathophysiology of primary headaches and provided unique insights into these syndromes. Modern imaging studies point, together with the clinical picture, towards a central triggering cause. The early functional imaging work using positron emission tomography shed light on the genesis of some syndromes, and has recently been refined, implying that the observed activation in migraine (brainstem) and in several trigeminal-autonomic headaches (hypothalamic grey) is involved in the pain process in either a permissive or triggering manner rather than simply as a response to first-division nociception per se. Using the advanced method of voxel-based morphometry, it has been suggested that there is a correlation between the brain area activated specifically in acute cluster headache — the posterior hypothalamic grey matter — and an increase in grey matter in the same region. No structural changes have been found for migraine and medication overuse headache, whereas patients with chronic tension-type headache demonstrated a significant grey matter decrease in regions known to be involved in pain processing. Modern neuroimaging thus clearly suggests that most primary headache syndromes are predominantly driven from the brain, activating the trigeminovascular reflex and needing therapeutics that act on both sides: centrally and peripherally

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Social Science Research Center Brochure

This brochure for the Social Science Research Center (SSRC) features details about the SSRC\u27s history, projects, research questions, internal and external sponsors, and features a letter from the director, Dr. Arthur Cosby.https://scholarsjunction.msstate.edu/ssrc-history/1002/thumbnail.jp

{(H3C)(3)NB(H)(2)NC}(2)Au AuI2 : a linear chain polymer of gold(I) iodide with an unusual isocyanoborane ligand showing aurophilic behaviour

Treatment of the (isocyanoborane) gold(I) chloride adduct [LAuCl] [L = (H3C)(3)NB(H)(2)NC] with KI at room temperature yields the unusal title compound, bis[isocyano(trimethylamino) borane] gold(I) diiodoaurate(I), [Au(C4H11BN2)(2)][ AuI2], which forms via an in situ rearrangement of isocyanoborane and halide ligands. The structure consists of alternating [L2Au](+) and [AuI2](-) ions, which form an infinite linear one-dimensional chain due to aurophilic Au...Au interactions. Both Au atoms occupy inversion centres