Temperature distribution and thermal anomalies along a flowline of the Greenland ice sheet

Englacial and basal temperature data for the Greenland ice sheet (GrIS) are sparse and mostly limited to deep interior sites and ice streams, providing an incomplete representation of the thermal state of ice within the ablation zone. Here we present 11 temperature profiles at five sites along a 34km east-west transect of West Greenland. These profiles depict ice temperatures along a flowline and local temperature variations between closely spaced boreholes. A temperate basal layer is present in all profiles, increasing in thickness in the flow direction, where it expands from about 3% of ice height furthest inland to 100% at the margin. Temperate thickness growth is inconsistent with modeled heat contributions from strain heating, heat conduction, and vertical extension of the temperate layer. We suggest that basal crevassing, facilitated by water pressures at or near ice overburden pressure, is responsible for the large temperate ice thicknesses observed. High-temperature kinks at 51-85m depth are likely remnants from the thermal influence of partially water-filled crevasses up ice sheet. Steep horizontal temperature gradients between closely grouped boreholes suggest the recent thermal influence of a moulin. These profiles demonstrate the ability of meltwater to rapidly alter ice temperatures at all depths within the ablation zone

Thermal tracking of meltwater retention in Greenland’s accumulation area

Poorly understood processes controlling retention of meltwater in snow and firn have important implications for Greenland Ice Sheet’s mass balance and flow dynamics. Here we present results from a 3 year (2007-2009) field campaign studying firn thermal profiles and density structure along an 85 km transect of the percolation zone of west Greenland. We installed one or two thermistor strings at 14 study sites, each string having 32 sensors spaced between 0 and 10 m depth. Data from our network of over 500 sensors were collected at 15-60 min intervals for 1-2 years, thereby recording the thermal signature of meltwater infiltration and refreezing during annual melt cycles. We document three types of heating of firn related to different mechanisms of meltwater motion and freezing, including heterogeneous breakthrough events, wetting front advance, and year-round heating from freezing of residual deep pore water. Vertically infiltrating meltwater commonly penetrates through cold firn accumulated over decades, even where ice layers are present at the previous summer surface and where ice layer thickness exceeds several decimeters. The offset between the mean annual air temperature and the 10 m firn temperature reveals the elevation dependency of meltwater retention along our transect. The firn is less than 10 degrees C warmer than the mean annual air temperature at the region where meltwater runoff initiates. During 2007-2009, runoff was limited to elevations lower than about 1500 m with no sharp runoff limit ; rather, the ratio of retention to runoff transitioned from all retention to all runoff across an about 20 km wide zone

Mapping subglacial surfaces of temperate valley glaciers by two-pass migration of a radio-echo sounding survey

High-resolution maps of the glacier bed are developed through a pseudo-three-dimensional migration of a dense array of radio-echo sounding profiles. Resolution of three-dimensional maps of sub-glacial surfaces is determined by the radio-echo sounding wavelength, data spacing in the field, and migration. Based on synthetic radio-echo sounding profile experiments, the maximum resolution of the final map cannot exceed one half-wavelength. A methodology of field and processing techniques is outlined to develop a maximum-resolution map of the glacier bed. The field and processing techniques valley glacier in south-central Alaska. The field techniques and the processing steps used on the glacier result in a map of 20 m x 20 m resolution

Thermal boundary conditions on western Greenland: Observational constraints and impacts on the modeled thermomechanical state

The surface and basal boundary conditions exert an important control on the thermodynamic state of the Greenland Ice Sheet, but their representation in numerical ice sheet models is poorly constrained due to the lack of observations. Here we investigate a land-terminating sector of western Greenland and (1) quantify differences between new observations and commonly used boundary condition data sets and (2) demonstrate the impact of improved boundary conditions on simulated thermodynamics in a higher-order numerical flow model. We constrain near-surface temperature with measurements from two 20mboreholes in the ablation zone and 10m firn temperature from the percolation zone. We constrain basal heat flux using in situ measurement in a deep bedrock hole at the study area margin and other existing assessments. To assess boundary condition influences on simulated thermal-mechanical processes, we compare model output to multiple full-thickness temperature profiles collected in the ablation zone.Our observation-constrained basal heat flux is 30mW m2 less than commonly used representations. In contract, measured near-surface temperatures are warmed than common surface warmer than common surface temperature data sets by up to 15 degrees C. Application of lower basal heat flux increases a model cold bias compared to the measured temperature profiles and causes frozen basal conditions across the ablation zone. Temperate basal conditions are reestablished by our warmer surface boundary. Warmer surface ice and firn can introduce several times more energy to the modeled ice mass than what is lost at the bed from reduced basal heat flux, indicating that the thermomechanical state of the ice sheet is highly sensitive to near-surface effects

Two Metrics Describing the Causes of Seasonal and Spatial Changes in Subglacial Aqueous Chemistry

Seasonal change in surface melt input and spatial controls on the distribution of subglacial water can cause considerable variability in the aqueous chemistry of subglacial waters. Much of this variability has been interpreted in terms of a single variable: water residence time, with slow flow assumed to correlate with greater mineral dissolution and oxidative weathering. We synthesize data from a range of glacier and ice sheet settings to show that this approach does not adequately describe presently available data. Instead, we propose that two independent variables control spatial and seasonal changes in aqueous chemistry in subglacial settings: atmospheric gas abundance and sediment supply abundance. Where atmospheric gases are abundant, carbonation weathering is responsible for most of the subglacial chemical activity; where they become limited, oxidation weathering becomes more dominant. Where freshly comminuted sediment is abundant, easily dissolved minerals, especially calcite, have proportionally more influence on subglacial hydrochemistry; where sediment supply is limited, silicate minerals, and less reactive carbonate minerals will increase in relative influence. In most settings, simple metrics of the abundance of SO42− and Ca2+ in the subglacial waters can characterize these two variables. In the data we synthesize, neither variable consistently correlates to the inferred water residence time, nor do the variables consistently correlate with each other. Spatial data show that point locations and small catchments on the glacial bed differ substantially from the integrated composition found at glacial outlets. The varied response in the subglacial aqueous chemistry to changing water residence times suggests complex control by a broad range of glaciological factors that affect water routing and subglacial sediment generation

Topographic control of asynchronous glacial advances: A case study from Annapurna, Nepal

Differences in the timing of glacial advances, which are commonly attributed to climatic changes, can be due to variations in valley topography. Cosmogenic 10Be dates from 24 glacial moraine boulders in 5 valleys define two age populations, late-glacial and early Holocene. Moraine ages correlate with paleoglacier valley hypsometries. Moraines in valleys with lower maximum altitudes date to the lateglacial, whereas those in valleys with higher maximum altitudes are early Holocene. Two valleys with similar equilibrium-line altitudes (ELAs), but contrasting ages, are \u3c 5 km apart and share the same aspect, such that spatial differences in climate can be excluded. A glacial mass-balance cellular automata model of these two neighboring valleys predicts that change from a cooler-drier to warmer-wetter climate (as at the Holocene onset) would lead to the glacier in the higher altitude catchment advancing, while the lower one retreats or disappears, even though the ELA only shifted by ~120 m

'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling control of cell behaviors for development of novel therapeutic strategies. Nanoparticle-based therapies benefit from such strategies but particle targeting to sites of neurological injury remains challenging due to circulatory immune clearance. As a strategy to overcome this barrier, the use of stealth coatings can reduce immune clearance and prolong circulatory times, thereby enhancing therapeutic capacity. Polyethylene glycol (PEG) is the most widely-used stealth coating and facilitates particle accumulation in the brain. However, once within the brain, the mode of handling of PEGylated particles by the resident immune cells of the brain itself (the ‘microglia’) is unknown. This is a critical question as it is well established that microglia avidly sequester nanoparticles, limiting their bioavailability and posing a major translational barrier. If PEGylation can be proved to promote evasion of microglia, then this information will be of high value in developing tailored nanoparticle-based therapies for neurological applications. Here, we have conducted the first comparative study of uptake of PEGylated particles by all the major (immune and non-immune) brain cell types. We prove for the first time that PEGylated nanoparticles evade major brain cell populations — a phenomenon which will enhance extracellular bioavailability. We demonstrate changes in protein coronas around these particles within biological media, and discuss how surface chemistry presentation may affect this process and subsequent cellular interactions

Clock-Comparison Tests of Lorentz and CPT Symmetry in Space

Clock-comparison experiments conducted in space can provide access to many unmeasured coefficients for Lorentz and CPT violation. The orbital configuration of a satellite platform and the relatively large velocities attainable in a deep-space mission would permit a broad range of tests with Planck-scale sensitivity.Comment: 4 page

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

No treatment for frontotemporal dementia (FTD), the second most common type of early-onset dementia, is available, but therapeutics are being investigated to target the 2 main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and tau (FTLD-tau). Testing potential therapies in clinical trials is hampered by our inability to distinguish between patients with FTLD-TDP and FTLD-tau. Therefore, we evaluated truncated stathmin-2 (STMN2) as a proxy of TDP-43 pathology, given the reports that TDP-43 dysfunction causes truncated STMN2 accumulation. Truncated STMN2 accumulated in human induced pluripotent stem cell-derived neurons depleted of TDP-43, but not in those with pathogenic TARDBP mutations in the absence of TDP-43 aggregation or loss of nuclear protein. In RNA-Seq analyses of human brain samples from the NYGC ALS cohort, truncated STMN2 RNA was confined to tissues and disease subtypes marked by TDP-43 inclusions. Last, we validated that truncated STMN2 RNA was elevated in the frontal cortex of a cohort of patients with FTLD-TDP but not in controls or patients with progressive supranuclear palsy, a type of FTLD-tau. Further, in patients with FTLD-TDP, we observed significant associations of truncated STMN2 RNA with phosphorylated TDP-43 levels and an earlier age of disease onset. Overall, our data uncovered truncated STMN2 as a marker for TDP-43 dysfunction in FTD