Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series

Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still missing. Three patients (2 with bipolar disorder, 1 with schizoaffective disorder) are described who showed a marked reduction of affective symptomatology after clozapine had been added to mood stabilizer pretreatment. The patients were seen once a month before and after the introduction of clozapine for at least 6 months. Treatment response was evaluated using different rating scales (IDS, YMRS; GAF; CGIBP) and the NIMH Life Chart Methodology. All patients showed a marked improvement after the add-on treatment with clozapine had been initiated. Clozapine was tolerated well with only transient and moderate weight gain and fatigue as only side effects. This case series underlines the safety and efficacy of clozapine as add-on medication in the treatment of bipolar and schizoaffective disorders. Copyright (C) 2002 S. Karger AG, Basel

A graphic identity program for the Thousand Acre Swamp sanctuary

People have often failed to appreciate the significance of wetlands. Lack of awareness has caused wetlands to be drained, filled, and polluted, to meet shortterm human needs. One half of the original 215 million acres of wetlands in the United States no longer exist. Best estimates indicate that we are continuing to loose 458,000 acres of our remaining wetlands each year. Wetlands have an enormous ability to produce and support plant and animal life. They rank among the most productive ecosystems in the world, and produce as much plant growth as tropical jungles, and 20 times as much plant material as the ocean. In addition, wetlands provide many valuable functions. Wetlands filter out pollutants, moderate flood waters, produce valuable crops, and are places of scenic beauty. It is my hope that my graphic design thesis project for The Thousand Acre Swamp Sanctuary will help people understand the interdependencies of nature, and increase public awareness about the importance of wetland areas and preserving the environment

Massive envelopes and filaments in the NGC 3603 star forming region

The formation of massive stars and their arrival on the zero-age main-sequence occurs hidden behind dense clouds of gas and dust. In the giant Hii region NGC 3603, the radiation of a young cluster of OB stars has dispersed dust and gas in its vicinity. At a projected distance of 2:5 pc from the cluster, a bright mid-infrared (mid-IR) source (IRS 9A) had been identified as a massive young stellar object (MYSO), located on the side of a molecular clump (MM2) of gas facing the cluster. We investigated the physical conditions in MM2, based on APEX sub-mm observations using the SABOCA and SHFI instruments, and archival ATCA 3 mm continuum and CS spectral line data. We resolved MM2 into several compact cores, one of them closely associated with IRS 9A. These are likely infrared dark clouds as they do not show the typical hot-core emission lines and are mostly opaque against the mid-IR background. The compact cores have masses of up to several hundred times the solar mass and gas temperatures of about 50 K, without evidence of internal ionizing sources. We speculate that IRS 9A is younger than the cluster stars, but is in an evolutionary state after that of the compact cores

Search of X-ray emission from roAp stars: The case of gamma Equulei

The detection of X-ray emission from Ap stars can be an indicator for the presence of magnetic activity and dynamo action, provided different origins for the emission, such as wind shocks and close late-type companions, can be excluded. Here we report on results for gamma Equu, the only roAp star for which an X-ray detection is reported in ROSAT catalogs. We use high resolution imaging in X-rays with Chandra and in the near-infrared with NACO/VLT that allow us to spatially resolve companions down to ~1" and ~0.06" separations, respectively. The bulk of the X-ray emission is associated with a companion of gamma Equu identified in our NACO image. Assuming coevality with the primary roAp star (~900 Myr), the available photometry for the companion points at a K-type star with ~0.6 M_sun. Its X-ray properties are in agreement with the predictions for its age and mass. An excess of photons with respect to the expected background and contribution from the nearby companion is observed near the optical position of gamma Equu. We estimate an X-ray luminosity of log L_x [erg/s] = 26.6 and log(L_x/L_bol) = -7.9 for this emission. A small offset between the optical and the X-ray image leaves some doubt on its association with the roAp star. The faint X-ray emission that we tentatively ascribe to the roAp star is difficult to explain as a solar-like stellar corona due to its very low L_x/L_bol level and the very long rotation period of gamma Equu. It could be produced in magnetically confined wind shocks implying a mass loss rate of ~10^(-14) M_sun/yr or from an additional unknown late-type companion at separation ~0.4". If confirmed by future deeper X-ray observations this emission could point at the origin for the presence of radioactive elements on some roAp stars.Comment: Accepted for publication in Astronomy & Astrophysics (5 pages

The Radio Properties of Composite LINER/HII Galaxies

Arcsec-resolution VLA observations -- newly obtained as well as published -- of 40 nearby galaxies are discussed, completing a study of the radio properties of a magnitude-limited sample of nearby galaxies of the composite LINER/HII type. Our results reveal an overall detection rate of at least 25% AGN candidates among these composite sources. The general properties of these AGN candidates, as compared to non-AGN composite sources and HII galaxies, are discussed.Comment: Accepted for publication in ApJ

Instant Two-Body Equation in Breit Frame

A quasipotential formalism for elastic scattering from relativistic bound states is based on applying an instant constraint to both initial and final states in the Breit frame. This formalism is advantageous for the analysis of electromagnetic interactions because current conservation and four momentum conservation are realized within a three-dimensional formalism. Wave functions are required in a frame where the total momentum is nonzero, which means that the usual partial wave analysis is inapplicable. In this work, the three-dimensional equation is solved numerically, taking into account the relevant symmetries. A dynamical boost of the interaction also is needed for the instant formalism, which in general requires that the boosted interaction be defined as the solution of a four-dimensional equation. For the case of a scalar separable interaction, this equation is solved and the Lorentz invariance of the three-dimensional formulation using the boosted interaction is verified. For more realistic interactions, a simple approximation is used to characterize the boost of the interaction.Comment: 20 pages in revtex 3, 3 figures. Fixed reform/tex errors

Estimating Be Star Disk Radii using H-alpha Emission Equivalent Widths

We present numerical models of the circumstellar disks of Be stars, and we describe the resulting synthetic H-alpha emission lines and maps of the wavelength-integrated emission flux projected onto the sky. We demonstrate that there are monotonic relationships between the emission line equivalent width and the ratio of the angular half-width at half maximum of the projected disk major axis to the radius of the star. These relationships depend mainly upon the temperatures of the disk and star, the inclination of the disk normal to the line of sight, and the adopted outer boundary for the disk radius. We show that the predicted H-alpha disk radii are consistent with those observed directly through long baseline interferometry of nearby Be stars (especially once allowance is made for disk truncation in binaries and for dilution of the observed H-alpha equivalent width by continuum disk flux in the V-band).Comment: 12 pages, 2 figures, ApJL in pres