267 research outputs found

    Toward a methodology for the AltaRica modelling of multi-physical systems

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    Numerous works deal with the use of the formal language AltaRica to improve the safety as-sessment process of industrial systems. In this context, the paper aims at describing and applying a common methodology to model physical systems. The example of a mechanical system and a hydro-mechanical system will be taken

    Toward a validation process for model based safety analysis

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    Today, Model Based processes become more and more widespread to achieve the analysis of a system. However, there is no formal testing approach to ensure that the formal model is compliant with the real system. In the paper, we choose to study AltaRica model. We present a general process to well construct and validate an AltaRica formal model. The focus is made on this validation phase, i.e. verifying the compliance between the model and the real system. For it, the proposed process recommends to build a specification for the AltaRica model. Then, the validation process is transformed to a classical verification problem between an implementation and a specification

    Calving Induced Speedup of Petermann Glacier

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    This study assesses the response on ice dynamics of Petermann Glacier, a major outlet glacier in northern Greenland, to the 2012 and a possible future calving event. So far Petermann Glacier has been believed to be dynamically stable as another large calving event in 2010 had no significant impact on flow velocity or grounding line retreat. By analyzing a time series of remotely sensed surface velocities, we find an average acceleration of 10% between winter 2011/2012 and winter 2016/2017. This increase in surface velocity is not linear but can be separated into two parts, starting in 2012 and 2016 respectively. By conducting modeling experiments, we show that the first speedup can be directly connected to the 2012 calving event, while the second speedup is not captured. However, on recent remote sensing imagery newly developing fractures are clearly visible ∼12 km upstream from the terminus, propagating from the eastern fjord wall to the center of the ice tongue, indicating a possible future calving event. By including these fracture zones as a new terminus position in the modeling domain, we are able to reproduce the second speedup, suggesting that surface velocities remain on the 2016/2017 level after the anticipated calving event. This indicates that, from a dynamical point of view, the terminus region has already detached from the main ice tongue

    On the evolution of an ice shelf melt channel at the base of Filchner Ice Shelf, from observations and viscoelastic modeling

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    Ice shelves play a key role in the stability of the Antarctic Ice Sheet due to their buttressing effect. A loss of buttressing as a result of increased basal melting or ice shelf disintegration will lead to increased ice discharge. Some ice shelves exhibit channels at the base that are not yet fully understood. In this study, we present in situ melt rates of a channel which is up to 330 m high and located in the southern Filchner Ice Shelf. Maximum observed melt rates are 2 m yr−1. Melt rates inside the channel decrease in the direction of ice flow and turn to freezing ∼55 km downstream of the grounding line. While closer to the grounding line melt rates are higher within the channel than outside, this relationship reverses further downstream. Comparing the modeled evolution of this channel under present-day climate conditions over 250 years with its present geometry reveals a mismatch. Melt rates twice as large as the present-day values are required to fit the observed geometry. In contrast, forcing the model with present-day melt rates results in a closure of the channel, which contradicts observations. The ice shelf experiences strong tidal variability in vertical strain rates at the measured site, and discrete pulses of increased melting occurred throughout the measurement period. The type of melt channel in this study diminishes in height with distance from the grounding line and is hence not a destabilizing factor for ice shelves.</p

    Integrin Alpha 8 Recessive Mutations Are Responsible for Bilateral Renal Agenesis in Humans

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    Renal hypodysplasia (RHD) is a heterogeneous condition encompassing a spectrum of kidney development defects including renal agenesis, hypoplasia, and (cystic) dysplasia. Heterozygous mutations of several genes have been identified as genetic causes of RHD with various severity. However, these genes and mutations are not associated with bilateral renal agenesis, except for RET mutations, which could be involved in a few cases. The pathophysiological mechanisms leading to total absence of kidney development thus remain largely elusive. By using a whole-exome sequencing approach in families with several fetuses with bilateral renal agenesis, we identified recessive mutations in the integrin α8-encoding gene ITGA8 in two families. Itga8 homozygous knockout in mice is known to result in absence of kidney development. We provide evidence of a damaging effect of the human ITGA8 mutations. These results demonstrate that mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease
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