Computer Control of Tactical Aircraft

Control Systems Laboratory changed its name to Coordinated Science LaboratoryContract DA-11-022-ORD-174, TB3-053

Multiple Correlations and High Tranverse Momentum Jets in 147-GeV/c pi- p Interactions

We examine multiparticle correlations in a {pi}{sup -}p experiment at 147 GeV/c performed by the Proportional Hybrid System Consortium. The major aim of this paper is to demonstrate the existence of clusters in our data. We use different statistical algorithms to assemble into clusters the particles in each event which are associated by virtue of small relative angles. We find that these clusters are stable against different choices of metric and/or algorithm, and reproduce the effects previously observed in the data corresponding to clusters. Some of these clusters have properties similar to high p{sub T} jets. A detailed study of these jet-like clusters is described, and comparisons with some counter experiments are discussed

Diffractive processes in p.bar.p interactions at 5.1 GeV/c

The interaction pp to pp pi /sup +/ pi /sup -/ at 5.1 GeV/c is investigated. By a selection in the variables of the kinetic energy of each particle, and the Van Hove angles of each event, the final state pp to Delta Delta is separated as well as the final states pp to (p pi /sup +/ pi /sup -/)p and pp to (p pi /sup +/ pi /sup -/)p where the particles in parentheses represent the dissociation of the proton and antiproton, respectively. (0 refs)

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker. Mice receiving a lethal dose of TETS (0.15 mg/kg i.p.) are rescued from death by a high dose of diazepam (5 mg/kg i.p.) administered shortly after the second clonic seizure (∼20 min post-TETS). However, this high dose of diazepam significantly impairs blood pressure and mobility, and does not prevent TETS-induced neuroinflammation in the brain. We previously demonstrated that TETS alters synchronous Ca(2+) oscillations in primary mouse hippocampal neuronal cell cultures and that pretreatment with the combination of diazepam and allopregnanolone at concentrations having negligible effects individually prevents TETS effects on intracellular Ca(2+) dynamics. Here, we show that treatment with diazepam and allopregnanolone (0.1 μM) 20 min after TETS challenge normalizes synchronous Ca(2+) oscillations when added in combination but not when added singly. Similarly, doses (0.03-0.1 mg/kg i.p.) of diazepam and allopregnanolone that provide minimal protection when administered singly to TETS intoxicated mice increase survival from 10% to 90% when given in combination either 10 min prior to TETS or following the second clonic seizure. This therapeutic combination has negligible effects on blood pressure or mobility. Combined treatment with diazepam and allopregnanolone also decreases TETS-induced microglial activation. Diazepam and allopregnanolone have distinct actions as positive allosteric modulators of GABAA receptors that in combination enhance survival and mitigate neuropathology following TETS intoxication without the adverse side effects associated with high dose benzodiazepines. Combination therapy with a benzodiazepine and neurosteroid represents a novel neurotherapeutic strategy with potentially broad application