A meta-analysis of genome-wide association studies identifies multiple longevity genes

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3�6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55 of the global rise in mean BMI from 1985 to 2017�and more than 80 in some low- and middle-income regions�was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing�and in some countries reversal�of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories. © 2019, The Author(s)

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol�which is a marker of cardiovascular risk�changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95 credible interval 3.7 million�4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world. © 2020, The Author(s), under exclusive licence to Springer Nature Limited

Assessment of decision-making regarding market entry/exit for technology innovation

Decision-making, Technology innovation, Real options, Discounted factor,

Juvenis de carpa capim alimentados com capim teosinto e suplementados com diferentes taxas de arraçoamento Grass carp juveniles fed with teosinte grass and supplied with different feeding rates

Avaliou-se o desenvolvimento de juvenis de carpa capim (Ctenopharyngodon idella) alimentados com capim teosinto (Euchlaena mexicana) e suplementados com ração. Realizaram-se dois experimentos, de 45 dias, utilizando 240 juvenis em cada um (peso médio: 10,9&plusmn;0,3g e 20,2&plusmn;0,2g). No experimento 1, os peixes foram alimentados com capim teosinto mais ração, em 4 níveis de suplementação: 1, 2, 3 e 4% do PV, denominados S1, S2, S3 e S4. No experimento 2, testou-se: C=Somente Capim Teosinto; SD=Capim Teosinto+ Suplementação diária (3%PV); SA=Capim Teosinto + Suplementação a cada dois dias (3%PV); R=Somente ração (3% PV). No experimento 1, observou-se aumento linear positivo do peso em relação à suplementação com ração. A melhor taxa de crescimento específico foi obtida com o tratamento S4. O rendimento de filé foi maior nos tratamentos S3 e S4. No experimento 2, para a variável peso, o tratamento SD diferiu significativamente dos demais. Os tratamentos SD, SA e R não diferiram estatisticamente em relação ao rendimento de filé, porém, houve diferença entre o tratamento SD e o C. Conclui-se que a associação do capim teosinto com a ração (3%PV) proporciona bom crescimento para juvenis de carpa capim.<br>This study was aimed at evaluating the growth of grass carp juveniles (Ctenopharyngodon idella) fed with teosinte grass (Euchlaena mexicana) and supplied with different feeding rates. Two experiments were done (45 days each), using 240 juveniles (weight=10.33 &plusmn; 0.33 and 20.15 &plusmn; 0.23g). In the first, four feeding rates (1, 2, 3 and 4% of body weight (BW), called S1, S2, S3 and S4 respectively) were tested. In the second, the treatments were: C = Only teosinte grass; SD = Teosinte grass + ration daily (3%BW); SA = Teosinte grass + ration each 2 days (3%BW); R = Only ration (3%BW). In the experiment 1, it was observed a weight increasing following the ration supply. The higher specific growth rate was obtained in S4. No differences among treatments was verify for carcass yield, however, the fillet yield was higher in S3 and S4. In the experiment 2, weight was higher in SD. The carcass yield (RC) did not present significant difference among the treatments in the experiment 2. Fillet yield was lower in fish fed only with teosinte grass (C). We concluded that the grass carp juveniles growing is positively affected by association of teosinte grass and ration supply, being necessary a minimum feeding rate (3%BW) daily for achieving good growth

Strategies for mitigation of nitrogen environmental impact from swine production Estratégias para minimização do impacto ambiental do azoto em suinicultura

This work presents strategies that can be implemented in order to minimize the environmental impact of swine slurry on soil, water, and air. This reduction can be achieved through decrease in nitrogen excretion and ammonia emissions. The correct feed formulation according to animal requirements, the increase in diet digestibility and improvement in animal performance can reduce nitrogen excretion. The use of additives either in the diet or in the manure as well as some equipment rearrangements can reduce ammonia emission.<br>Neste trabalho são apresentadas estratégias que podem ser implementadas para minimizar o impacto ambiental dos efluentes da produção suína sobre o solo, a água e a atmosfera. Esta redução pode ser obtida com a excreção de azoto e a sua volatilização. A formulação mais ajustada às necessidades dos animais, o aumento da digestibilidade da dieta e a melhoria do desempenho dos animais podem reduzir a excreção de azoto. O uso de aditivos nas dietas ou nos dejectos e alterações nas instalações pode reduzir a volatilização da amónia