Ethyl 3-bromo-1-(3-chloro-2-pyrid­yl)-4,5-dihydro-1H-pyrazole-5-carboxyl­ate

The title compound, C11H11BrClN3O2, contains two mol­ecules in the asymmetric unit in which the dihedral angles between the pyrazole and pyridine rings are 30.0 (2) and 22.3 (2)°

The effects of environmental inspection on air quality: Evidence from China

To address ecological and environmental issues, central environmental inspection (CEI) coordinated by the Chinese Ministry of Ecology and Environment has been implemented since 2016. This paper aims to comprehensively evaluate how and how much CEI affects air quality. The results of the difference-in-differences models show that CEI improved the air quality and reduced the concentrations of PM2.5, PM10, NO2, and SO2 by 8.8%, 8.1%, 7.9%, and 2.4%, respectively. Moreover, environmental effectiveness was strengthened over the course of four rounds of inspection. The mediating model results indicate that effectiveness was achieved through active public participation, administrative punishments from the central inspectors, and positive rectification actions from the local governments. The greatest improvement in air quality occurred during the on-site inspection period, after which the effects gradually weakened. A review inspection was carried out to supervise the rectification tasks. The adoption of review inspection made the effects on air quality improvement reappear, which verifies that CEI in China is not just a temporary campaign-style enforcement but a normalized and effective governance of air pollution

A graph-cut approach to image segmentation using an affinity graph based on l0−sparse representation of features

International audienceWe propose a graph-cut based image segmentation method by constructing an affinity graph using l0 sparse representation. Computing first oversegmented images, we associate with all segments, that we call superpixels, a collection of features. We find the sparse representation of each set of features over the dictionary of all features by solving a l0-minimization problem. Then, the connection information between superpixels is encoded as the non-zero representation coefficients, and the affinity of connected superpixels is derived by the corresponding representation error. This provides a l0 affinity graph that has interesting properties of long range and sparsity, and a suitable graph cut yields a segmentation. Experimental results on the BSD database demonstrate that our method provides perfectly semantic regions even with a constant segmentation number, but also that very competitive quantitative results are achieved

Air pollution control or economic development? Empirical evidence from enterprises with production restrictions

Production restriction is an environmental regulation adopted in China to curb the air pollution of industrial enterprises. Frequent production restrictions may cause economic losses for enterprises and further hinder their green transformation. Polluting enterprises are faced with the dilemma of choosing environmental protection or economic development. Using panel data on industrial enterprises in China from 2016 to 2019, this paper evaluates the impact of production restrictions on both enterprises' environmental and economic performance with regression models. The results show that production restrictions significantly drop the concentrations of SO2 and NOx emitted from polluting enterprises. Meanwhile, production restrictions have significant negative effects on operating income, financial expenses, net profit, and environmental protection investment. The mechanism analysis reveals that production restrictions mitigate air pollutant concentrations by increasing the number of green patents and improving total factor productivity, which also verifies the Porter hypothesis. However, there is a masking mediating effect of environmental investment, which indicates that the reduction of environmental investment hinders the enterprise's efforts to control air pollution. In addition, heterogeneous analysis shows that the economic shock on microenterprises is larger than that on small enterprises. Implementing production restrictions for microenterprises may be a way to eliminate their backwards production capacity

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

BACKGROUND: Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis. METHODS: The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed. RESULTS: All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas. CONCLUSION: The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis