Mechanisms of change in psychotherapy for depression:An empirical update and evaluation of research aimed at identifying psychological mediators

We present a systematic empirical update and critical evaluation of the current status of research aimed at identifying a variety of psychological mediators in various forms of psychotherapy for depression. We summarize study characteristics and results of 35 relevant studies, and discuss the extent to which these studies meet several important requirements for mechanism research. Our review indicates that in spite of increased attention for the topic, advances in theoretical consensus about necessities for mechanism research, and sophistication of study designs, research in this field is still heterogeneous and unsatisfactory in methodological respect. Probably the biggest challenge in the field is demonstrating the causal relation between change in the mediator and change in depressive symptoms. The field would benefit from a further refinement of research methods to identify processes of therapeutic change. Recommendations for future research are discussed. However, even in the most optimal research designs, explaining psychotherapeutic change remains a challenge. Psychotherapy is a multi-dimensional phenomenon that might work through interplay of multiple mechanisms at several levels. As a result, it might be too complex to be explained in relatively simple causal models of psychological change

Conductance fluctuations and weak localization in chaotic quantum dots

We study the conductance statistical features of ballistic electrons flowing through a chaotic quantum dot. We show how the temperature affects the universal conductance fluctuations by analyzing the influence of dephasing and thermal smearing. This leads us to two main findings. First, we show that the energy correlations in the transmission, which were overlooked so far, are important for calculating the variance and higher moments of the conductance. Second, we show that there is an ambiguity in the method of determination of the dephasing rate from the size of the of the weak localization. We find that the dephasing times obtained at low temperatures from quantum dots are underestimated.Comment: 4 pages, 4 figures, to appear in Phys. Rev. Let

Spin orbit effects in a GaAs quantum dot in a parallel magnetic field

We analyze the effects of spin-orbit coupling on fluctuations of the conductance of a quantum dot fabricated in a GaAs heterostructure. We argue that spin-orbit effects may become important in the presence of a large parallel magnetic field B_{||}, even if they are negligble for B_{||}=0. This should be manifest in the level repulsion of a closed dot, and in reduced conductance fluctuations in dots with a small number of open channels in each lead, for large B_{||}. Our picture is consistent with the experimental observations of Folk et al.Comment: 5 page

Distributions of the Conductance and its Parametric Derivatives in Quantum Dots

Full distributions of conductance through quantum dots with single-mode leads are reported for both broken and unbroken time-reversal symmetry. Distributions are nongaussian and agree well with random matrix theory calculations that account for a finite dephasing time, $\tau_\phi$, once broadening due to finite temperature $T$ is also included. Full distributions of the derivatives of conductance with respect to gate voltage $P(dg/dV_g)$ are also investigated.Comment: 4 pages (REVTeX), 4 eps figure

Treatment of Intrusive Suicidal Imagery Using Eye Movements

Suicide and suicidal behavior are major public health concerns, and affect 3–9% of the population worldwide. Despite increased efforts for national suicide prevention strategies, there are still few effective interventions available for reducing suicide risk. In this article, we describe various theoretical approaches for suicide ideation and behavior, and propose to examine the possible effectiveness of a new and innovative preventive strategy. A model of suicidal intrusion (mental imagery related to suicide, also referred to as suicidal flash-forwards) is presented describing one of the assumed mechanisms in the etiology of suicide and the mechanism of therapeutic change. We provide a brief rationale for an Eye Movement Dual Task (EMDT) treatment for suicidal intrusions, describing techniques that can be used to target these suicidal mental images and thoughts to reduce overall behavior. Based on the available empirical evidence for the mechanisms of suicidal intrusions, this approach appears to be a promising new treatment to prevent suicidal behavior as it potentially targets one of the linking pins between suicidal ideation and suicidal actions

Spin Degeneracy and Conductance Fluctuations in Open Quantum Dots

The dependence of mesoscopic conductance fluctuations on parallel magnetic field is used as a probe of spin degeneracy in open GaAs quantum dots. The variance of fluctuations at high parallel field is reduced from the low-field variance (with broken time-reversal symmetry) by factors ranging from roughly two in a 1 square-micron dot at low temperature, to four or greater in 8 square-micron dots. The factor of two is expected for simple Zeeman splitting of spin degenerate channels. A possible explanation for the unexpected larger factors in terms of field-dependent spin orbit scattering is proposed.Comment: Includes new reference to related theoretical work, cond-mat/0010064. Other minor changes. Related papers at http://marcuslab.harvard.ed

The Thermopower of Quantum Chaos

The thermovoltage of a chaotic quantum dot is measured using a current heating technique. The fluctuations in the thermopower as a function of magnetic field and dot shape display a non-Gaussian distribution, in agreement with simulations using Random Matrix Theory. We observe no contributions from weak localization or short trajectories in the thermopower.Comment: 4 pages, 3 figures, corrected: accidently omitted author in the Authors list, here (not in the article

Dephasing in the semiclassical limit is system-dependent

We investigate dephasing in open quantum chaotic systems in the limit of large system size to Fermi wavelength ratio, $L/\lambda_F >> 1$. We semiclassically calculate the weak localization correction $g^{wl}$ to the conductance for a quantum dot coupled to (i) an external closed dot and (ii) a dephasing voltage probe. In addition to the universal algebraic suppression $g^{wl} \propto (1+\tau_D/\tau_\phi)^{-1}$ with the dwell time $\tau_D$ through the cavity and the dephasing rate $\tau_\phi^{-1}$, we find an exponential suppression of weak localization by a factor $\propto \exp[-\tilde{\tau}/\tau_\phi]$, with a system-dependent $\tilde{\tau}$. In the dephasing probe model, $\tilde{\tau}$ coincides with the Ehrenfest time, $\tilde{\tau} \propto \ln [L/\lambda_F]$, for both perfectly and partially transparent dot-lead couplings. In contrast, when dephasing occurs due to the coupling to an external dot, $\tilde{\tau} \propto \ln [L/\xi]$ depends on the correlation length $\xi$ of the coupling potential instead of $\lambda_F$.Comment: 4 pages 3 figures (v2 contains numerous cosmetic changes

Scattering properties of a cut-circle billiard waveguide with two conical leads

We examine a two-dimensional electron waveguide with a cut-circle cavity and conical leads. By considering Wigner delay times and the Landauer-B\"{u}ttiker conductance for this system, we probe the effects of the closed billiard energy spectrum on scattering properties in the limit of weakly coupled leads. We investigate how lead placement and cavity shape affect these conductance and time delay spectra of the waveguide.Comment: 18 pages, 11 figures, accepted for publication in Phys. Rev. E (Jan. 2001

Prediction of Long-Term Sickness Absence Among Employees with Depressive Complaints

Introduction To study the properties of a screening instrument in predicting long-term sickness absence among employees with depressive complaints. Methods Employees at high risk of future sickness absence were selected by the screening instrument Balansmeter (BM). Depressive complaints were assessed with the depression scale of the Hospital Anxiety and Depression Scale. The total study population consisted of 7,401 employees. Sickness absence was assessed objectively and analyzed at 12 and 18 months of follow-up using company registers on certified sick leave. Results The relative risk (RR) for long-term sickness absence, for employees at high risk versus not at high risk, was 3.26 (95% CI 2.54–4.22) in men and 2.55 (1.98–3.35) in women, when the BM was applied in the total study population. The RR of long-term sickness absence of employees with depressive complaints compared with employees without depressive complaints was 3.13 (2.41–4.09) in men and 2.45 (2.00–3.00) in women. The RR of long-term sickness absence for the BM applied in employees with depressive complaints was 5.23 in men and 3.87 in women. When the BM with a cut-off point with a higher sensitivity was applied in employees with depressive complaints, the RR for long-term sickness absence was 4.88 in men and 3.80 in women. Conclusions The screening instrument Balansmeter is able to predict long-term sickness absence within employees with depressive complaints. The total prediction of long-term sickness absence proved better in employees with depressive complaints compared with employees of a general working population