The Relationships among Senior High School Teacher Perceptions on Professional Learning Community, Self-efficacy, School Type, and Gender

Teacher’s professional learning community (TPLC) and self-efficacy(SE) are considered to enhance student learning in various dimensions. Teacher perceived PLC and SE might be influenced by school contexts and teachers’ demographic factors. This study investigated the relationships between teacher’s professional learning community (PLC), self-efficacy (SE), school type, and gender in Taiwan context. The findings are expected to provide valuable information in this field and to enhance understanding of PLC and self-efficacy in different cultural contexts. Descriptive statistics, t-test, product-moment correlation, and multiple regression analysis were applied to analyze the data. The findings indicated that a significant difference was found between public school teachers and private school teachers in two PLC dimensions, core element and human and social resources, and in one SE dimesnion, classroom management. Another significant differences were found between male teachers and female teachers in three SE dimensions, teaching strategy, classroom management, and student involvement. However, no significant differences was found between both in PLC dimesnions. Moreover, perceived PLC and SE were positive correlated. Perceived PLC could predict perceived SE. These results suggested that PLC appears to play a role in teachers’ reported levels of SE and provided initial evidence that the variation between schools in PLC may be explained by the SE. Keywords: Gender, school type, self-efficacy, professional learning community, senior high school teacher

Proactive measures of governmental debt guarantees to facilitate Public-Private Partnerships project

Governmental Debt Guarantees (GDGs) are often used to encourage involvement by promoters and financial institutions in Public-Private Partnerships (PPP) projects. However, even after demonstrating the bankability of a project and reducing debt cost, the success of the project may be prevented by the lack of long-term commitment from shareholders. Equity contributions by promoters in the project company may be recovered from earnings on short-term construction activities. Based on lesson learned from early PPP projects with GDG, the hold-up problem for government in the view of transaction cost economic (TCE) theory may worsen if the designed contractual structure does not adequately manage opportunistic behaviours from promoters. This study empirically examined the effects of a structured GDG mechanism with particular complementary measures applied in joint projects to develop the Taipei Mass Rapid Transit (MRT) stations. A GDG game model was then applied to bridge the theoretical gap based on the Taipei MRT experience. The analysis shows that requiring the promoter to provide sufficient equity and ensuring the commitment of the lender to provide the loan are the appropriate proactive measures. This study demonstrates its practical value for policy makers by combining case study, TCE and game theory in contractual issues

Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence

Entry of the human immunodeficiency virus (HIV) into the target cell is initiated by fusion with the cell membrane, mediated through the envelope glycoproteins gp120 and gp41, following engagement to CD4 and the co-receptor. Previous fusion kinetics studies on the HXB2 envelope protein (Env) revealed that Env recruitment occurred at about 13 min concurrent with the lipid mixing. To resolve the temporal sequence of lipid mixing and recruitment, we employed an inhibitory assay monitored by fluorescence microscopy using a gp41 ectodomain (gp41e) fragment, which blocked Env recruitment in stark contrast to the lack of gp41e effect on the lipid mixing. In addition, to demonstrate the mode of action for the inhibition of gp41e, our results strongly suggested that lipid mixing precedes the Env recruitment because lipid mixing can proceed with Env recruitment inhibited by exogeneous gp41e molecules. Importantly, it was found that the random clustering of Env molecules on the membrane surface occurred at ~1 minute whereas the Env recruitment was observed at 13 minutes after the attachment of Env-expressing cell to the target cell. This > 10-fold temporal discrepancy highlights that the productive assembly of Env molecules leading to fusion requires spatio-temporal coordination of several adjacent Env trimers aggregated via directed movement

Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors

A potential role may be played by receptor-type protein tyrosine phosphatase kappa (PTPRK) in angiogenesis due to its critical function in coordinating intracellular signal transduction from various receptors reliant on tyrosine phosphorylation. In the present study, we investigated the involvement of PTPRK in the cellular functions of vascular endothelial cells (HECV) and its role in angiogenesis using in vitro assays and a PTPRK knockdown vascular endothelial cell model. PTPRK knockdown in HECV cells (HECVPTPRKkd) resulted in a decrease of cell proliferation and cell-matrix adhesion; however, increased cell spreading and motility were seen. Reduced focal adhesion kinase (FAK) and paxillin protein levels were seen in the PTPRK knockdown cells which may contribute to the inhibitory effect on adhesion. HECVPTPRKkd cells were more responsive to the treatment of fibroblast growth factor (FGF) in their migration compared with the untreated control and cells treated with VEGF. Moreover, elevated c-Src and Akt1 were seen in the PTPRK knockdown cells. The FGF-promoted cell migration was remarkably suppressed by an addition of PLCγ inhibitor compared with other small inhibitors. Knockdown of PTPRK suppressed the ability of HECV cells to form tubules and also impaired the tubule formation that was induced by FGF and conditioned medium of cancer cells. Taken together, it suggests that PTPRK plays dual roles in coordinating angiogenesis. It plays a positive role in cell proliferation, adhesion and tubule formation, but suppresses cell migration, in particular, the FGF-promoted migration. PTPRK bears potential to be targeted for the prevention of tumour associated angiogenesis

Identifying the attack sources of botnets for a renewable energy management system by using a revised locust swarm optimisation scheme

Distributed denial of service (DDoS) attacks often use botnets to generate a high volume of packets and adopt controlled zombies for flooding a victim’s network over the Internet. Analysing the multiple sources of DDoS attacks typically involves reconstructing attack paths between the victim and attackers by using Internet protocol traceback (IPTBK) schemes. In general, traditional route-searching algorithms, such as particle swarm optimisation (PSO), have a high convergence speed for IPTBK, but easily fall into the local optima. This paper proposes an IPTBK analysis scheme for multimodal optimisation problems by applying a revised locust swarm optimisation (LSO) algorithm to the reconstructed attack path in order to identify the most probable attack paths. For evaluating the effectiveness of the DDoS control centres, networks with a topology size of 32 and 64 nodes were simulated using the ns-3 tool. The average accuracy of the LS-PSO algorithm reached 97.06 for the effects of dynamic traffic in two experimental networks (number of nodes = 32 and 64). Compared with traditional PSO algorithms, the revised LSO algorithm exhibited a superior searching performance in multimodal optimisation problems and increased the accuracy in traceability analysis for IPTBK problems