4-Hydr­oxy-2,2,6,6-tetra­methyl­piperidinium perchlorate

In the title salt, C9H20NO+·ClO4 −, inter­molecular hydrogen bonds are observed, which determine the crystal packing

p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum

The localization of many secretory mRNAs to the endoplasmic reticulum does not require ribosomes or translation, but is instead promoted by p180, an abundant, membrane-bound protein that likely binds directly to mRNA

Magneto hydrodynamic simulations of the supernova remnant G1.9+0.3

The youngest Galactic supernova remnant G1.9+0.3 shows a discrete feature between its radio and X-ray morphologies. The observed radio morphology features a single maximum in the north, while the X-ray observation shows two opposite 'ears' on the east and west sides. Using 3D magneto hydrodynamical simulations, we investigate the formation of the discrete feature of the remnant. We have tested different parameters for better simulation and reproduced similar discrete features under an environment with density gradient and an environment with clump, which provides a possible explanation of the observation

catena-Poly[[(5-phenyl-2,2′-bipyridine-κ2 N,N′)copper(I)]-μ-thio­cyanido-κ2 N:S]

The title compound, [Cu(NCS)(C16H12N2)]n, was synthesised under hydro­thermal conditions. The CuI ion shows distorted tetra­hedral geometry being coordinated by two N atoms from a 5-phenyl-2,2′-bipyridine ligand and by the N and S atoms from two different thio­cyanate anions. The CuI ions are bridged by thio­cyanide groups, forming a one-dimensional coordination polymer along the b axis. The crystal packing is through van der Waals contacts and C—H⋯π inter­actions

A Comprehensive Survey on Database Management System Fuzzing: Techniques, Taxonomy and Experimental Comparison

Database Management System (DBMS) fuzzing is an automated testing technique aimed at detecting errors and vulnerabilities in DBMSs by generating, mutating, and executing test cases. It not only reduces the time and cost of manual testing but also enhances detection coverage, providing valuable assistance in developing commercial DBMSs. Existing fuzzing surveys mainly focus on general-purpose software. However, DBMSs are different from them in terms of internal structure, input/output, and test objectives, requiring specialized fuzzing strategies. Therefore, this paper focuses on DBMS fuzzing and provides a comprehensive review and comparison of the methods in this field. We first introduce the fundamental concepts. Then, we systematically define a general fuzzing procedure and decompose and categorize existing methods. Furthermore, we classify existing methods from the testing objective perspective, covering various components in DBMSs. For representative works, more detailed descriptions are provided to analyze their strengths and limitations. To objectively evaluate the performance of each method, we present an open-source DBMS fuzzing toolkit, OpenDBFuzz. Based on this toolkit, we conduct a detailed experimental comparative analysis of existing methods and finally discuss future research directions.Comment: 34 pages, 22 figure

MiR-143-5p inhibits proliferation, invasion, and epithelial to mesenchymal transition of colorectal cancer cells by downregulation of HMGA2

Purpose: To investigate the regulatory effect and molecular mechanism of miR-143-5p in colorectal cancer (CRC) progression. Methods: Expression of miR-143-5p in CRC cell lines SW620 and HCT116 was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Stable miR-143-5p overexpression was mediated by lentivirus. The effects of miR-143-5p on proliferation, migration, invasion, and epithelial- mesenchymal transition (EMT) of SW620 and HCT116 cells were assessed by colony formation assay, CCK-8, Transwell assay, wound healing assay, and western blot. Target prediction was performed for miR-143-5p, and a dual luciferase assay was used to verify the targeting relationship. Results: Compared to CRC cells transfected with negative controls, cell proliferation, migration and invasion, and EMT were inhibited in miR-143-5p-overexpressing cells. Expression of HMGA2 (high- mobility Group AT-Hook 2), a target gene of miR-143-5p, was repressed by miR-143-5p. Rescue experiments confirmed that upregulation of HMGA2 due to mIR-143-5p overexpression reversed inhibition of CRC cell proliferation, invasion and EMT. Conclusion: MiR-143-5p inhibits the malignant progression of CRC by regulating HMGA2 expression and is expected to provide new therapeutic approaches for clinical treatment of CRC