Time-Domain Astronomy with the Fermi Gamma-Ray Burst Monitor in the Multi-Messenger Era

No abstract availabl

Time-Domain Astronomy with the Fermi Gamma-Ray Burst Monitor

No abstract availabl

New High Energy Views of the Galaxy:The HAWC Galactic Plane Survey

No abstract availabl

Gamma-Ray Astronomy Across 6 Decades of Energy: Synergy between Fermi, IACTs, and HAWC

Gamma Ray Observatories, Gamma-Ray Astrophysics, GeV TeV Sky Survey, Galaxy, Galactic Plane, Source Distribution, The gamma-ray sky is currently well-monitored with good survey coverage. Many instruments from different waveband/messenger (X rays, gamma rays, neutrinos, gravitational waves) available for simultaneous observations. Both wide-field and pointing instruments in development and coming online in the next decade LIG

Coenzyme Q10 deficiencies: pathways in yeast and humans.

Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant. In human and yeast cells, CoQ synthesis derives from aromatic ring precursors and the isoprene biosynthetic pathway. Saccharomyces cerevisiae coq mutants provide a powerful model for our understanding of CoQ biosynthesis. This review focusses on the biosynthesis of CoQ in yeast and the relevance of this model to CoQ biosynthesis in human cells. The COQ1-COQ11 yeast genes are required for efficient biosynthesis of yeast CoQ. Expression of human homologs of yeast COQ1-COQ10 genes restore CoQ biosynthesis in the corresponding yeast coq mutants, indicating profound functional conservation. Thus, yeast provides a simple yet effective model to investigate and define the function and possible pathology of human COQ (yeast or human gene involved in CoQ biosynthesis) gene polymorphisms and mutations. Biosynthesis of CoQ in yeast and human cells depends on high molecular mass multisubunit complexes consisting of several of the COQ gene products, as well as CoQ itself and CoQ intermediates. The CoQ synthome in yeast or Complex Q in human cells, is essential for de novo biosynthesis of CoQ. Although some human CoQ deficiencies respond to dietary supplementation with CoQ, in general the uptake and assimilation of this very hydrophobic lipid is inefficient. Simple natural products may serve as alternate ring precursors in CoQ biosynthesis in both yeast and human cells, and these compounds may act to enhance biosynthesis of CoQ or may bypass certain deficient steps in the CoQ biosynthetic pathway

Transients with the Fermi GBM

No abstract availabl

MoonBEAM: A Beyond-LEO Gamma-Ray Burst Detector for Gravitational-Wave Astronomy

No abstract availabl

Gamma Rays in the Modern Multi-Messenger Astronomy Era

Summary: GW170817 / GRB 170817A is one of the best observed transient and highlights the science impact of multi-messenger observations; Many open questions remain, with increased GW (Gravitational Wave) interferometer sensitivity, there will be more joint detections with GBM (Gamma-ray Burst Monitor), enabling deeper population studies of SGRBs (Short Gamma-Ray Bursts) -Additional distance measures which yield source energetics -Constrain jet structure and opening angle distribution -Cocoon emission from SGRBs -Causes of precursor and extended emission -Rates of SGRBs in the universe with implications for source evolution; Fermi GBM is currently the most prolific short GRB detector -Subthreshold searches are crucial to increasing GBM sensitivity and the detection horizon to weakevents like GRB 170817A; Looking forward to future multimessenger discoveries -Neutron star...Black hole merger, neutrinos, Fast Radio Bursts