27 research outputs found

    Wolves in the Wolds: Late Capitalism, the English Eerie, and the Wyrd Case of ‘Old Stinker’ the Hull Werewolf

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    In this article, I depart from the earlier opinions of Emily Gerard, Sabine Baring-Gould, and others, who explained the disappearance of the werewolf in folklore as following the extinction of the wolf. I argue instead that British literature is distinctive in representing a history of werewolf sightings in places in Britain where there were once wolves. I draw on the idea of absence, manifestations of the English eerie, and the turbulence of England in the era of late capitalism to illuminate my analysis of the representation of contemporary werewolf sightingsPeer reviewe

    Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

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    Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

    UNIVERSITY OF SOUTH DAKOTA FACULTY AND STUDENT PERSPECTIVES ON SUSTAINABILITY EDUCATION

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    The concept of sustainability is taught and understood in multiple ways, and how one perceives sustainability is likely to affect how they engage with the field. This thesis research focuses on sustainability faculty and undergraduate students at the University of South Dakota and how they perceive sustainability education. I conducted semistructured interviews to determine faculty and student perspectives regarding sustainability, sustainability education, and the undergraduate sustainability curriculum at the University of South Dakota. There are many different ways to approach sustainability such as content knowledge, systems thinking, and an interdisciplinary approach. Overall, the perceptions of sustainability education from the participants were cohesive and aligned well. The participants sustainability definitions aligned with the Brundtland Commission definition and the widely acknowledged “three pillars”. Climate change and resource management were identified as common issues within the field of sustainability. A mix of many different curricular styles and structures such as the interdisciplinary approach and content matter including understanding the earth’s systems and climate change were shared as valuable pieces of sustainability education. Currently, these styles, structures, and content matter are reflected in the undergraduate sustainability curriculum at the University of South Dakota. However, based on feedback from the interviews I provide possible improvements for the sustainability undergraduate curriculum including class offerings, expansions within the Department of Sustainability & Environment, and creating a more navigable catalog

    We Build Our Own Monuments

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    Letters and recollections of John Murray Forbes;

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    Mode of access: Internet

    Herschel, Caroline Lucretia

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