2,171 research outputs found

    Fractal Conductance Fluctuations of Classical Origin

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    In mesoscopic systems conductance fluctuations are a sensitive probe of electron dynamics and chaotic phenomena. We show that the conductance of a purely classical chaotic system with either fully chaotic or mixed phase space generically exhibits fractal conductance fluctuations unrelated to quantum interference. This might explain the unexpected dependence of the fractal dimension of the conductance curves on the (quantum) phase breaking length observed in experiments on semiconductor quantum dots.Comment: 5 pages, 4 figures, to appear in PR

    Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

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    A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS). Taking advantage of parallel accumulation-serial fragmentation (PASEF), we fragment on average 15 precursors in each of 100 ms TIMS scans, while maintaining the full mobility resolution of co-eluting isomers. The acquisition speed of over 100 Hz allows us to obtain MS/MS spectra of the vast majority of isotope patterns. Analyzing 1 mu L of human plasma, PASEF increases the number of identified lipids more than three times over standard TIMS-MS/MS, achieving attomole sensitivity. Building on high intra- and inter-laboratory precision and accuracy of TIMS collisional cross sections (CCS), we compile 1856 lipid CCS values from plasma, liver and cancer cells. Our study establishes PASEF in lipid analysis and paves the way for sensitive, ion mobility-enhanced lipidomics in four dimensions

    Assessment of Cognitive Functioning Following Training in Hatha Yoga

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    This study explores the relationship between training in Hatha Yoga and performance on selected cognitive tests. The psychological processes presumed to underlie these tests include field independence and freedom from distractibility. Although past research has suggested the possibility of a relationship between certain meditative techniques and cognitive functioning, this study failed to support that evidence. Various experimental conditions are recognized as contributing to the somewhat unexpected results and the implications of these limitations to further research is discussed.Applied Behavioral Studie

    Rainforests at the beginning of the 21st century

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    Rainforests are situated at low latitude where forests enjoy steady and strong radiation. Biodiversity in rainforests has been very high, for historical and climatic reasons. The number of species is very high and tends to increase with precipitation and decrease with seasonality. Disturbance, soil fertility and forest stature also influence the species richness and high turnover of species contribute to diversity. Field observation and studies revealed that large scale deforestation could alter the regional and global climate significantly. Deforestation alters the surface albedo which leads to climate change. Regional land use contributes to climate change through surface-energy budget, as well as the carbon cycle. Forest fragmentation, logging, overhunting, fire and the expanding agriculture threaten the biodiversity. Rainforest covered area has significantly shrunk in the last decades. It is hard to protect the forests because of the growing demand for agricultural area and forest-derived products. Most measures proved ineffective to slow down the destruction. Hence, more forest will be lost in the future. Conservationists should take into consideration the secondary forests because biodiversity can be high enough and it is worth protecting them

    Fast Adaptive Optics for High-Dimensional Quantum Communications in Turbulent Channels

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    Quantum Key Distribution (QKD) promises a provably secure method to transmit information from one party to another. Free-space QKD allows for this information to be sent over great distances and in places where fibre-based communications cannot be implemented, such as ground-satellite. The primary limiting factor for free-space links is the effect of atmospheric turbulence, which can result in significant error rates and increased losses in QKD channels. Here, we employ the use of a high-speed Adaptive Optics (AO) system to make real-time corrections to the wavefront distortions on spatial modes that are used for high-dimensional QKD in our turbulent channel. First, we demonstrate the effectiveness of the AO system in improving the coupling efficiency of a Gaussian mode that has propagated through turbulence. Through process tomography, we show that our system is capable of significantly reducing the crosstalk of spatial modes in the channel. Finally, we show that employing AO reduces the quantum dit error rate for a high-dimensional orbital angular momentum-based QKD protocol, allowing for secure communication in a channel where it would otherwise be impossible. These results are promising for establishing long-distance free-space QKD systems.Comment: 8 pages, 5 figures, supplemetary material include

    Learning Latent Factor Models of Travel Data for Travel Prediction and Analysis

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    Abstract. We describe latent factor probability models of human travel, which we learn from data. The latent factors represent interpretable properties: travel distance cost, desirability of destinations, and affinity between locations. Individuals are clustered into distinct styles of travel. The latent factors combine in a multiplicative manner, and are learned using Maximum Likelihood. We show that our models explain the data significantly better than histogrambased methods. We also visualize the model parameters to show information about travelers and travel patterns. We show that different individuals exhibit different propensity to travel large distances. We extract the desirability of destinations on the map, which is distinct from their popularity. We show that pairs of locations have different affinities with each other, and that these affinities are partly explained by travelers ’ preference for staying within national borders and within the borders of linguistic areas. The method is demonstrated on two sources of travel data: geotags from Flickr images, and GPS tracks from Shanghai taxis.

    Mechanical Stress Inference for Two Dimensional Cell Arrays

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    Many morphogenetic processes involve mechanical rearrangement of epithelial tissues that is driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular adhesion are not only the targets of regulation, but are themselves likely signals that coordinate developmental process. Yet, because it is difficult to directly measure mechanical stress {\it in vivo} on sub-cellular scale, little is understood about the role of mechanics of development. Here we present an alternative approach which takes advantage of the recent progress in live imaging of morphogenetic processes and uses computational analysis of high resolution images of epithelial tissues to infer relative magnitude of forces acting within and between cells. We model intracellular stress in terms of bulk pressure and interfacial tension, allowing these parameters to vary from cell to cell and from interface to interface. Assuming that epithelial cell layers are close to mechanical equilibrium, we use the observed geometry of the two dimensional cell array to infer interfacial tensions and intracellular pressures. Here we present the mathematical formulation of the proposed Mechanical Inverse method and apply it to the analysis of epithelial cell layers observed at the onset of ventral furrow formation in the {\it Drosophila} embryo and in the process of hair-cell determination in the avian cochlea. The analysis reveals mechanical anisotropy in the former process and mechanical heterogeneity, correlated with cell differentiation, in the latter process. The method opens a way for quantitative and detailed experimental tests of models of cell and tissue mechanics
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