Interpretation of Light-Quenching Factor Measurements

We observe that the pattern of the quenching factors for scintillation light from various ions, recently studied in $CaWO_4$ in connection with dark matter detectors, can be understood as a saturation phenomenon in which the light output is simply proportional to track length, independent of the ion and its energy. This observation is in accord with the high dE/dx limit of Birks' law. It suggests a simple model for the intrinsic resolution of light detectors for low energy ions, which we briefly discuss.Comment: Seven pages, seven figures, some with colo

Space Radiation Effects on Human Cells: Modeling DNA Breakage, DNA Damage Foci Distribution, Chromosomal Aberrations and Tissue Effects

Future long-tem space travel will face challenges from radiation concerns as the space environment poses health risk to humans in space from radiations with high biological efficiency and adverse post-flight long-term effects. Solar particles events may dramatically affect the crew performance, while Galactic Cosmic Rays will induce a chronic exposure to high-linear-energy-transfer (LET) particles. These types of radiation, not present on the ground level, can increase the probability of a fatal cancer later in astronaut life. No feasible shielding is possible from radiation in space, especially for the heavy ion component, as suggested solutions will require a dramatic increase in the mass of the mission. Our research group focuses on fundamental research and strategic analysis leading to better shielding design and to better understanding of the biological mechanisms of radiation damage. We present our recent effort to model DNA damage and tissue damage using computational models based on the physics of heavy ion radiation, DNA structure and DNA damage and repair in human cells. Our particular area of expertise include the clustered DNA damage from high-LET radiation, the visualization of DSBs (DNA double strand breaks) via DNA damage foci, image analysis and the statistics of the foci for different experimental situations, chromosomal aberration formation through DSB misrepair, the kinetics of DSB repair leading to a model-derived spectrum of chromosomal aberrations, and, finally, the simulation of human tissue and the pattern of apoptotic cell damage. This compendium of theoretical and experimental data sheds light on the complex nature of radiation interacting with human DNA, cells and tissues, which can lead to mutagenesis and carcinogenesis later in human life after the space mission

Identification and proposed control of helicopter transmission noise at the source

Helicopter cabin interiors require noise treatment which is expensive and adds weight. The gears inside the main power transmission are major sources of cabin noise. Work conducted by the NASA Lewis Research Center in measuring cabin interior noise and in relating the noise spectrum to the gear vibration of the Army OH-58 helicopter is described. Flight test data indicate that the planetary gear train is a major source of cabin noise and that other low frequency sources are present that could dominate the cabin noise. Companion vibration measurements were made in a transmission test stand, revealing that the single largest contributor to the transmission vibration was the spiral bevel gear mesh. The current understanding of the nature and causes of gear and transmission noise is discussed. It is believed that the kinematical errors of the gear mesh have a strong influence on that noise. The completed NASA/Army sponsored research that applies to transmission noise reduction is summarized. The continuing research program is also reviewed

Genotoxic Effects of Low- and High-LET Radiation on Human Epithelial Cells Grown in 2-D Versus 3-D Culture

Risk estimation for radiation-induced cancer relies heavily on human epidemiology data obtained from terrestrial irradiation incidents from sources such as medical and occupational exposures as well as from the atomic bomb survivors. No such data exists for exposures to the types and doses of high-LET radiation that will be encountered during space travel; therefore, risk assessment for space radiation requires the use of data derived from cell culture and animal models. The use of experimental models that most accurately replicate the response of human tissues is critical for precision in risk projections. This work compares the genotoxic effects of radiation on normal human epithelial cells grown in standard 2-D monolayer culture compared to 3-D organotypic co-culture conditions. These 3-D organotypic models mimic the morphological features, differentiation markers, and growth characteristics of fully-differentiated normal human tissue and are reproducible using defined components. Cultures were irradiated with 2 Gy low-LET gamma rays or varying doses of high-LET particle radiation and genotoxic damage was measured using a modified cytokinesis block micronucleus assay. Our results revealed a 2-fold increase in residual damage in 2 Gy gamma irradiated cells grown under organotypic culture conditions compared to monolayer culture. Irradiation with high-LET particle radiation gave similar results, while background levels of damage were comparable under both scenarios. These observations may be related to the phenomenon of "multicellular resistance" where cancer cells grown as 3-D spheroids or in vivo exhibit an increased resistance to killing by chemotherapeutic agents compared to the same cells grown in 2-D culture. A variety of factors are likely involved in mediating this process, including increased cell-cell communication, microenvironment influences, and changes in cell cycle kinetics that may promote survival of damaged cells in 3-D culture that would otherwise die or be rendered reproductively inactive in 2-D culture

Characterization of Three-Stream Jet Flow Fields

Flow-field measurements were conducted on single-, dual- and three-stream jets using two-component and stereo Particle Image Velocimetry (PIV). The flow-field measurements complimented previous acoustic measurements. The exhaust system consisted of externally-plugged, externally-mixed, convergent nozzles. The study used bypass-to-core area ratios equal to 1.0 and 2.5 and tertiary-to-core area ratios equal to 0.6 and 1.0. Axisymmetric and offset tertiary nozzles were investigated for heated and unheated high-subsonic conditions. Centerline velocity decay rates for the single-, dual- and three-stream axisymmetric jets compared well when axial distance was normalized by an equivalent diameter based on the nozzle system total exit area. The tertiary stream had a greater impact on the mean axial velocity for the small bypass-to-core area ratio nozzles than for large bypass-to-core area ratio nozzles. Normalized turbulence intensities were similar for the single-, dual-, and three-stream unheated jets due to the small difference (10%) in the core and bypass velocities for the dual-stream jets and the low tertiary velocity (50% of the core stream) for the three-stream jets. For heated jet conditions where the bypass velocity was 65% of the core velocity, additional regions of high turbulence intensity occurred near the plug tip which were not present for the unheated jets. Offsetting the tertiary stream moved the peak turbulence intensity levels upstream relative to those for all axisymmetric jets investigated

Introduction to the Anti-Racism Virtual Issue of the Journal of Occupational Science

The anti-racism virtual issue of the Journal of Occupational Science (JOS) came about after the Editorial Board expressed its commitment to anti-racist work, publishing the position statement ‘A Pledge to Mobilize Against Racism’ (Stanley et al., 2020). In this statement, the Board promised to republish a collection of articles to call attention to racism and its impact on individuals’ doing and society. The intent is to stimulate critical reflection on the contribution occupational scientists can make to exposing and countering racism in everyday doing. As such, the anti-racism virtual issue helps meet a pressing need to recognize the power of occupation in shaping and reproducing social ideologies, attitudes, and behaviors. We, the authors, urge all occupational scientists to build on this knowledge and continue learning about racism to better understand and address how its different dimensions manifest through occupation and everyday life