33 research outputs found

    Precision Primordial 4^4He Measurement with CMB Experiments

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    Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) are two major pillars of cosmology. Standard BBN accurately predicts the primordial light element abundances (4^4He, D, 3^3He and 7^7Li), depending on one parameter, the baryon density. Light element observations are used as a baryometers. The CMB anisotropies also contain information about the content of the universe which allows an important consistency check on the Big Bang model. In addition CMB observations now have sufficient accuracy to not only determine the total baryon density, but also resolve its principal constituents, H and 4^4He. We present a global analysis of all recent CMB data, with special emphasis on the concordance with BBN theory and light element observations. We find ΩBh2=0.025+0.0019−0.0026\Omega_{B}h^{2}=0.025+0.0019-0.0026 and Yp=0.250+0.010−0.014Y_{p}=0.250+0.010-0.014 (fraction of baryon mass as 4^4He) using CMB data alone, in agreement with 4^4He abundance observations. With this concordance established we show that the inclusion of BBN theory priors significantly reduces the volume of parameter space. In this case, we find ΩBh2=0.0244+0.00137−0.00284\Omega_{B}h^2=0.0244+0.00137-0.00284 and Yp=0.2493+0.0006−0.001Y_p = 0.2493+0.0006-0.001. We also find that the inclusion of deuterium abundance observations reduces the YpY_p and ΩBh2\Omega_{B}h^2 ranges by a factor of ∌\sim 2. Further light element observations and CMB anisotropy experiments will refine this concordance and sharpen BBN and the CMB as tools for precision cosmology.Comment: 7 pages, 3 color figures made minor changes to bring inline with journal versio

    Measuring α\alpha in the Early Universe: CMB Temperature, Large-Scale Structure and Fisher Matrix Analysis

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    We extend our recent work on the effects of a time-varying fine-structure constant α\alpha in the cosmic microwave background, by providing a thorough analysis of the degeneracies between α\alpha and the other cosmological parameters, and discussing ways to break these with both existing and/or forthcoming data. In particular, we present the state-of-the-art CMB constraints on α\alpha, through a combined analysis of the BOOMERanG, MAXIMA and DASI datasets. We also present a novel discussion of the constraints on α\alpha coming from large-scale structure observations, focusing in particular on the power spectrum from the 2dF survey. Our results are consistent with no variation in α\alpha from the epoch of recombination to the present day, and restrict any such (relative) variation to be less than about 4%. We show that the forthcoming MAP and (particularly) Planck experiments will be able to break most of the currently existing degeneracies between α\alpha and other parameters, and measure α\alpha to better than percent accuracy.Comment: 11 pages in RevTex4 format. Low-quality figures to comply with arXiv restrictions (better ones available from the authors). v2: Updated Oklo discussion, plus other cosmetic changes. Version to appear in Phys Rev

    Primordial He4 Abundance Constrains the Possible Time Variation of the Higgs Vacuum Expectation Value

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    We constrain the possible time variation of the Higgs vacuum expectation value (vv) by recent results on the primordial 4He^4He abundance (YPY_P). For that, we use an analytic approach which enables us to take important issues into consideration, that have been ignored by previous works, like the vv-dependence of the relevant cross sections of deuterium production and photodisintegration, including the full Klein- Nishina cross section. Furthermore, we take a non-equilibrium Ansatz for the freeze-out concentration of neutrons and protons and incorporate the latest results on the neutron decay. Finally, we approximate the key-parameters of the primordial 4He^4He production (the mean lifetime of the free neutron and the binding energy of the deuteron) by terms of vv0v\over v_0 (where v0v_0 denotes the present theoretical estimate). Eventually, we derive the relation YP≃0.2479−5.54(v−v0v0)2−0.808 (v−v0v0)Y_P \simeq 0.2479 - 5.54 (\frac{v-v_0}{v_0})^2 - 0.808~ (\frac{v-v_0}{v_0}) and the most stringent limit on a possible time variation of vv is given by: −5.4⋅10−4≀v−v0v0≀4.4⋅10−4-5.4 \cdot 10^{-4} \leq \frac{v-v_0}{v_0} \leq 4.4 \cdot 10^{-4}.Comment: Accepted for publication in IJT

    Cartilage immunoprivilege depends on donor source and lesion location

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    The ability to repair damaged cartilage is a major goal of musculoskeletal tissue engineering. Allogeneic (same species, different individual) or xenogeneic (different species) sources can provide an attractive source of chondrocytes for cartilage tissue engineering, since autologous (same individual) cells are scarce. Immune rejection of non-autologous hyaline articular cartilage has seldom been considered due to the popular notion of “cartilage immunoprivilege.” The objective of this study was to determine the suitability of allogeneic and xenogeneic engineered neocartilage tissue for cartilage repair. To address this, scaffold-free tissue engineered articular cartilage of syngeneic (same genetic background), allogeneic, and xenogeneic origin were implanted into two different locations of the rabbit knee (n=3 per group/location). Xenogeneic engineered cartilage and control xenogeneic chondral explants provoked profound innate inflammatory and adaptive cellular responses, regardless of transplant location. Cytological quantification of immune cells showed that, while allogeneic neocartilage elicited an immune response in the patella, negligible responses were observed when implanted into the trochlea; instead the responses were comparable to microfracture-treated empty defect controls. Allogeneic neocartilage survived within the trochlea implant site and demonstrated graft integration into the underlying bone. In conclusion, the knee joint cartilage does not represent an immune privileged site, strongly rejecting xenogeneic but not allogeneic chondrocytes in a location-dependent fashion. This difference in location-dependent survival of allogeneic tissue may be associated with proximity to the synovium

    Primordial Nucleosynthesis for the New Cosmology: Determining Uncertainties and Examining Concordance

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    Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) have a long history together in the standard cosmology. The general concordance between the predicted and observed light element abundances provides a direct probe of the universal baryon density. Recent CMB anisotropy measurements, particularly the observations performed by the WMAP satellite, examine this concordance by independently measuring the cosmic baryon density. Key to this test of concordance is a quantitative understanding of the uncertainties in the BBN light element abundance predictions. These uncertainties are dominated by systematic errors in nuclear cross sections. We critically analyze the cross section data, producing representations that describe this data and its uncertainties, taking into account the correlations among data, and explicitly treating the systematic errors between data sets. Using these updated nuclear inputs, we compute the new BBN abundance predictions, and quantitatively examine their concordance with observations. Depending on what deuterium observations are adopted, one gets the following constraints on the baryon density: OmegaBh^2=0.0229\pm0.0013 or OmegaBh^2 = 0.0216^{+0.0020}_{-0.0021} at 68% confidence, fixing N_{\nu,eff}=3.0. Concerns over systematics in helium and lithium observations limit the confidence constraints based on this data provide. With new nuclear cross section data, light element abundance observations and the ever increasing resolution of the CMB anisotropy, tighter constraints can be placed on nuclear and particle astrophysics. ABRIDGEDComment: 54 pages, 20 figures, 5 tables v2: reflects PRD version minor changes to text and reference

    Psychosocial Treatment of Children in Foster Care: A Review

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    A substantial number of children in foster care exhibit psychiatric difficulties. Recent epidemiologi-cal and historical trends in foster care, clinical findings about the adjustment of children in foster care, and adult outcomes are reviewed, followed by a description of current approaches to treatment and extant empirical support. Available interventions for these children can be categorized as either symptom-focused or systemic, with empirical support for specific methods ranging from scant to substantial. Even with treatment, behavioral and emotional problems often persist into adulthood, resulting in poor functional outcomes. We suggest that self-regulation may be an important mediat-ing factor in the appearance of emotional and behavioral disturbance in these children

    Psychosocial Treatment of Children in Foster Care: A Review

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