Rhabdomyolysis attenuates activity of semicarbazide sensitive amine oxidase as the marker of nephropathy in diabetic rats

Amine oxidases are involved in the progression of many diseases and their complications, including renal failure, due to the generation of the three toxic metabolites (H2O2, aldehydes, and ammonia) in the course of biogenic amines oxidative deamination. The participation of the first two products in kidney pathogenesis was confirmed, whereas the role of ammonia as a potential inducer of the nitrozative stress is not yet understood. The aim of the present study was to test how further intensification of oxidative stress would affect diabetes-mediated metabolic changes. For this purpose, a rat model of glycerol-induced rhabdomyolysis, as a source of powerful oxidative stress due to the release of labile Fe3+ from ruptured myocytes, on the background of streptozotocin-induced diabetes was used. The experimental animal groups were as follows: group 1 – ‘Control’, group 2 – ‘Diabetes’, group 3 – ‘Diabetes + rhabdomyolysis’. A multifold increase in semicarbazide sensitive amine oxidase (SSAO) activity in the kidney and blood, free radicals (FR), MetHb and 3-nitrotyrosine (3-NT) levels in the blood, as well as the emergence of HbNO in plasma and dinitrosyl iron complexes (DNICs) in the liver of animals in group 2 as compared to control were revealed. An additional increase in FR, HbNO levels in the blood, and DNICs in the liver of animals in the diabetes + rhabdomyolysis group as compared to the diabetes group, which correlated with the appearance of a large amount of Fe3+ in the blood of group 3 animals, was detected. Unexpectedly, we observed the positive regulatory effects in animals of the diabetes + rhabdomyolysis group, in particular, a decreased SSAO activity in the kidney and 3-NT level in plasma, as well as the normalization of activity of pro- and antioxidant enzymes in the blood and liver compared to animals of diabetes group. These consequences mediated by rhabdomyolysis may be the result of NO exclusion from the circulation due to the excessive formation of NO stable complexes in the blood and liver. The data obtained allow us to consider SSAO activity as a marker of renal failure in diabetes mellitus. In addition, we suggest a significant role of nitrosative stress in the development of pathology, and, therefore, recommend NO-traps in the complex treatment of diabetic complications

MODEL OF FORMING OF PROFESSIONAL INTEGRATIVE- SERVICE COMPETENSE OF SPECIALIST OF INDUSTRY OF FEED AND HOSPITALITY

В статье показано, что индустрия питания и гостеприимства, развивается быстрыми темпами и нуждается в инновациях, способных поднять уровень услуг в соответствии с возрастающими требованиями потребителей. Соответственно появляется необходимость подготовки специалистов, имеющих фундаментальные, профессиональные знания в области индустрии питания и гостеприимства, стремящихся к творческой самореализации, так как эффективное внедрение любых инноваций невозможно при низкой квалификации персонала и его слабой мотивации. Рассмотренная авторами модель формирования профессиональной интегративно-сервисной компетенции будущего специалиста индустрии питания и гостеприимства в среднем профессиональном образовании, включает взаимосвязанные целевую, методическую и результативную составляющие, а также механизм контроля формирования данной компетенции.The article shows that the catering and hospitality industry, is growing rapidly and needs in innovation, capable of raising the level of services in accordance with the growing demands of consumers. Accordingly, there is need to train specialists with fundamental and professional knowledge in the field of catering and hospitality industry, striving for creative self-realization, as the effective implementation of any innovation is impossible for unskilled personnel and their weak motivation.Considered the authors model of integrative professional competence of the future expert service food and hospitality industry in the secondary vocational education, including related task, methodological and productive components, as well as a mechanism to monitor the formation of this competence

Position observations of NEAs at the RTT150

In 2004-2007, 560 observations of 17 Near-Earth Asteroids of 15-21 magnitudes were made at the Russian-Turkish telescope (RTT150). The reduction was made using reference stars from the UCAC2 and USNO-B1 catalogues. The comparison of the observed and calculated positions of the asteroids using the HORIZONS system gave standard errors of a single position in the range 0.05÷H 0.50″. Analysis of the (O - C) is given in this paper. © 2008 American Institute of Physics

Results of observations of asteroids at the Russian–Turkish RTT-150 telescope from 2004–2013

© 2015, Allerton Press, Inc. We report the results of analysis of the data volume containing 13834 topocentric positions of 231 asteroids obtained from observations at the Russian–Turkish RTT-150 telescope (TÜBITAK (Scientific and Technological Research Council of Turkey), Turkey) in 2004–2013. The positions of asteroids were calculated with the differential reduction method in the ICRS system with the use of the reference catalogs of the UCAC series. The observational program covered the main-belt asteroids closely encountering the other asteroids and the near-Earth asteroids (NEA). For the main belt asteroids, the mean-square error of one position was 84 and 68 mas in right ascension and declination, respectively, while it was 160 and 120 mas, respectively, for NEAs. The obtained volume of the asteroid positions widens the arc of groundbased observations of these bodies, which is important for evaluating their orbital elements with a higher accuracy. Moreover, observations of the main-belt asteroids in the periods of close encounters yield valuable material to solve the problem on accurate estimation of the masses of asteroids with a dynamic method. It has been shown that the supplementing of the input dataset with the here-reported observational volume decreases the error in the estimates of the perturbing asteroid mass and the orbital parameters of perturbed bodies

Position observations of NEAs at the RTT150

In 2004-2007, 560 observations of 17 Near-Earth Asteroids of 15-21 magnitudes were made at the Russian-Turkish telescope (RTT150). The reduction was made using reference stars from the UCAC2 and USNO-B1 catalogues. The comparison of the observed and calculated positions of the asteroids using the HORIZONS system gave standard errors of a single position in the range 0.05÷H 0.50″. Analysis of the (O - C) is given in this paper. © 2008 American Institute of Physics

Position observations of NEAs at the RTT150

In 2004-2007, 560 observations of 17 Near-Earth Asteroids of 15-21 magnitudes were made at the Russian-Turkish telescope (RTT150). The reduction was made using reference stars from the UCAC2 and USNO-B1 catalogues. The comparison of the observed and calculated positions of the asteroids using the HORIZONS system gave standard errors of a single position in the range 0.05÷H 0.50″. Analysis of the (O - C) is given in this paper. © 2008 American Institute of Physics

Position observations of NEAs at the RTT150

In 2004-2007, 560 observations of 17 Near-Earth Asteroids of 15-21 magnitudes were made at the Russian-Turkish telescope (RTT150). The reduction was made using reference stars from the UCAC2 and USNO-B1 catalogues. The comparison of the observed and calculated positions of the asteroids using the HORIZONS system gave standard errors of a single position in the range 0.05÷H 0.50″. Analysis of the (O - C) is given in this paper. © 2008 American Institute of Physics

Interleukin-1 activity in aged animals. Abstr.

© 2015, Allerton Press, Inc. We report the results of analysis of the data volume containing 13834 topocentric positions of 231 asteroids obtained from observations at the Russian–Turkish RTT-150 telescope (TÜBITAK (Scientific and Technological Research Council of Turkey), Turkey) in 2004–2013. The positions of asteroids were calculated with the differential reduction method in the ICRS system with the use of the reference catalogs of the UCAC series. The observational program covered the main-belt asteroids closely encountering the other asteroids and the near-Earth asteroids (NEA). For the main belt asteroids, the mean-square error of one position was 84 and 68 mas in right ascension and declination, respectively, while it was 160 and 120 mas, respectively, for NEAs. The obtained volume of the asteroid positions widens the arc of groundbased observations of these bodies, which is important for evaluating their orbital elements with a higher accuracy. Moreover, observations of the main-belt asteroids in the periods of close encounters yield valuable material to solve the problem on accurate estimation of the masses of asteroids with a dynamic method. It has been shown that the supplementing of the input dataset with the here-reported observational volume decreases the error in the estimates of the perturbing asteroid mass and the orbital parameters of perturbed bodies

Results of observations of asteroids at the Russian–Turkish RTT-150 telescope from 2004–2013

© 2015, Allerton Press, Inc. We report the results of analysis of the data volume containing 13834 topocentric positions of 231 asteroids obtained from observations at the Russian–Turkish RTT-150 telescope (TÜBITAK (Scientific and Technological Research Council of Turkey), Turkey) in 2004–2013. The positions of asteroids were calculated with the differential reduction method in the ICRS system with the use of the reference catalogs of the UCAC series. The observational program covered the main-belt asteroids closely encountering the other asteroids and the near-Earth asteroids (NEA). For the main belt asteroids, the mean-square error of one position was 84 and 68 mas in right ascension and declination, respectively, while it was 160 and 120 mas, respectively, for NEAs. The obtained volume of the asteroid positions widens the arc of groundbased observations of these bodies, which is important for evaluating their orbital elements with a higher accuracy. Moreover, observations of the main-belt asteroids in the periods of close encounters yield valuable material to solve the problem on accurate estimation of the masses of asteroids with a dynamic method. It has been shown that the supplementing of the input dataset with the here-reported observational volume decreases the error in the estimates of the perturbing asteroid mass and the orbital parameters of perturbed bodies