DISTURBING DISTRACTIONS: INVESTIGATING THE IM-PACT OF DIGITAL AND NON-DIGITAL DISTRACTIONS ON TASK PERFORMANCE

Connection norms have forced individuals to keep their smartphone within arm’s length to be reachable anytime-anywhere. This has led to strong connection habits that, paired with the boundless nature of the smartphone, have increased the possibilities of being exposed to distracting (auditory) cues trigger-ing smartphone related habits. In this study we investigate whether digital (sound) distractions were more distracting compared to non-digital (sound) distractions as a result of smartphones being highly prevalent in our society and how a local distraction effect might impact overall task performance. We found that digital distractions did have a local distraction effect, but these local distractions did not amount to any significant group differences in terms of overall task performance. Although, it was found that individuals exposed to digital distractions reported increased perceived mental effort, -task diffi-culty, -subjective distraction and reduced perceived attention paid to the task compared to the non-digital and control groups

Opposing effects of dopamine antagonism in a motor sequence task—tiapride increases cortical excitability and impairs motor learning

The dopaminergic system is involved in learning and participates in the modulation of cortical excitability (CE). CE has been suggested as a marker of learning and use-dependent plasticity. However, results from separate studies on either motor CE or motor learning challenge this notion, suggesting opposing effects of dopaminergic modulation upon these parameters: while agonists decrease and antagonists increase CE, motor learning is enhanced by agonists and disturbed by antagonists. To examine whether this discrepancy persists when complex motor learning and motor CE are measured in the same experimental setup, we investigated the effects of dopaminergic (DA) antagonism upon both parameters and upon task-associated brain activation. Our results demonstrate that DA-antagonism has opposing effects upon motor CE and motor sequence learning. Tiapride did not alter baseline CE, but increased CE post training of a complex motor sequence while simultaneously impairing motor learning. Moreover, tiapride reduced activation in several brain regions associated with motor sequence performance, i.e. dorsolateral PFC, supplementary motor area, Broca's area, cingulate and caudate body. Blood-oxygenation-level-dependent ( BOLD) intensity in anterior cingulate and caudate body, but not CE, correlated with performance across groups. In summary, our results do not support a concept of CE as a general marker of motor learning, since they demonstrate that a straightforward relation of increased CE and higher learning success does not apply to all instances of motor learning. At least for complex motor tasks that recruit a network of brain regions outside motor cortex, CE in primary motor cortex is probably no central determinant for learning success

Integrated Management: A Coastal Community Perspective

This paper was prepared for the Food and Agriculture Organisation of the United Nations Regional Workshops on Small-Scale Fisheries "Securing Sustainable Small-Scale Fisheries: Bringing together responsible fisheries and social development". It presents a review of what are seen as 'good practices' globally in policy and governance of small-scale fisheries, with a particular focus on addressing rights-based issues, viewed broadly as incorporating fishery rights, other rights to natural resources, and rights and entitlements in relation to human, social and economic rights. It draws extensively on the 1995 Code of Conduct for Responsible Fisheries and related technical guidelines, particularly those concerning small-scale fisheries and their roles in poverty alleviation and food security, and the human dimensions of the ecosystem approach to fisheries. The paper is also strongly informed by the papers prepared for and outcomes of the 2008 Global Conference on "Securing Sustainable Small-Scale Fisheries: Bringing together responsible fisheries and social development" and the relevant rights-oriented components of the 'Bangkok Statement' produced by the Civil Society Preparatory Workshop for the Global Conference. It also draws upon a set of research documents in the international literature focusing on small-scale fisheries and related policy issues [e.g., Allison et al. (2010), Charles (2009, 2011), McConney and Charles (2009); Kurien (2000, 2007)]

an In Vitro Study

The poor healing potential of tendons is still a clinical problem, and the use of Platelet Rich Plasma (PRP) was hypothesized to stimulate healing. As the efficacy of PRPs remains unproven, platelet lysate (PL) could be an alternative with its main advantages of storage and characterization before use. Five different blood products were prepared from 16 male donors: human serum, two PRPs (Arthrex, (PRP-ACP); RegenLab (PRP-BCT)), platelet concentrate (apheresis, PC), and PL (freezing-thawing destruction of PC). Additionally, ten commercial allogenic PLs (AlloPL) from pooled donors were tested. The highest concentration of most growth factors was found in AlloPL, whereas the release of growth factors lasted longer in the other products. PRP-ACP, PRP- BCT, and PC significantly increased cell viability of human tenocyte-like cells, whereas PC and AlloPL increased Col1A1 expression and PRP-BCT increased Col3A1 expression. MMP-1, IL-1β, and HGF expression was significantly increased and Scleraxis expression decreased by most blood products. COX1 expression significantly decreased by PC and AlloPL. No clear positive effects on tendon cell biology could be shown, which might partially explain the weak outcome results in clinical practice. Pooled PL seemed to have the most beneficial effects and might be the future in using blood products for tendon tissue regeneration

Constrained Spectrum Control

A novel Nonlinear Model Predictive Control (NMPC) scheme is proposed in order to shape the harmonic response of constrained nonlinear systems. The salient ingredient is the short-time Fourier transform (STFT) of the system's output signal, which is constrained in an NMPC problem, leading to the novel formulation of so-called spectrum constraints. Recursive feasibility and asymptotic stability of the proposed NMPC scheme with such spectrum constraints are guaranteed by means of an appropriate ellipsoidal terminal invariant set. The efficacy of the proposed approach is demonstrated on a nonlinear vibration damping problem

Spectrogram MPC: Enforcing hard constraints on system's output spectra

A novel model predictive control (MPC) scheme that allows one to enforce hard constraints on the spectrum of a constrained system’s output signal is presented. The approach is based on a time-local analysis of the spectrum of output signals by means of the short-time Fourier transform (STFT), and its squared magnitude, called the spectrogram. It is shown that an MPC problem with spectrogram constraints can be formulated as a quadratically constrained quadratic program (QCQP). We prove recursive feasibility and stability of the proposed spectrogram MPC scheme via an ellipsoidal invariant set, including spectrogram constraints. Moreover, it is pointed out how the proposed spectrogram MPC approach can be extended to MPC for tracking while ensuring recursive feasibility. Finally, we present simulation results of spectrogram MPC applied to a resonant system. Our simulations show that, by employing the proposed spectrogram MPC approach, oscillations can be attenuated in the system output, tracking a reference signal, by explicitly enforcing hard constraints on its spectrum

Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats

Fifty spontaneously breathing pentobarbital-anesthetized cats were used to determine the incidence rate and parameters of short reflex expirations induced by mechanical stimulation of the tracheal mucosa (ERt). The mechanical stimuli evoked coughs; in addition, 67.6% of the stimulation trials began with ERt. The expiration reflex mechanically induced from the glottis (ERg) was also analyzed (99.5% incidence, p < 0.001 compared to the incidence of ERt). We found that the amplitudes of abdominal, laryngeal abductor posterior cricoarytenoid, and laryngeal adductor thyroarytenoid electromyograms (EMG) were significantly enhanced in ERg relative to ERt. Peak intrathoracic pressure (esophageal or intra-pleural pressure) was higher during ERg than ERt. The interval between the peak in EMG activity of the posterior cricoarytenoid muscle and that of the EMG of abdominal muscles was lower in ERt compared to ERg. The duration of thyroarytenoid EMG activity associated with ERt was shorter than that in ERg. All other temporal features of the pattern of abdominal, posterior cricoarytenoid, and thyroarytenoid muscles EMGs were equivalent in ERt and ERg

Predictors of abatacept retention over 2 years in patients with rheumatoid arthritis: results from the real-world ACTION study.

Objectives Evaluate abatacept retention over 2 years in the AbataCepT In rOutiNe clinical practice (ACTION) study

Prognostic factors for abatacept retention in patients who received at least one prior biologic agent: an interim analysis from the observational, prospective ACTION study

Background: The emergence of new therapies for the treatment of rheumatoid arthritis (RA), the paucity of head-to-head studies, and the heterogeneous nature of responses to current biologics highlight the need for the identification of prognostic factors for treatment response and retention in clinical practice. Prognostic factors for patient retention have not been explored thoroughly despite data for abatacept and other biologics being available from national registries. Real-world data from the ACTION study may supplement the findings of randomized controlled trials and show how abatacept is used in clinical practice. The aim of this interim analysis was to identify prognostic factors for abatacept retention in patients with RA who received at least one prior biologic agent. Methods: A large, international, non-interventional cohort of patients with moderate-to-severe RA who initiated intravenous abatacept in Canada and Europe (May 2008–January 2011) enrolled in the ACTION study. Potential prognostic factors for retention in this interim analysis (data cut-off February 2012; including patients from Canada, Germany, Greece, and Italy) were baseline demographics and disease characteristics, medical history, and previous and concomitant medication. Clinically relevant variables with p ≤ 0.20 in univariate analysis and no collinearity were entered into a Cox proportional hazards regression model, adjusted for clustered data. Variables with p ≤ 0.10 were retained in the final model (backward selection). Results: The multivariate model included 834 patients. Anti-cyclic citrullinated peptide (CCP) antibody positivity (hazard ratio [95 % confidence interval]: 0.55 [0.40, 0.75], p &lt; 0.001), failure of &lt;2 prior anti-tumor necrosis factors (TNFs) (0.71 [0.56, 0.90], p = 0.005 versus ≥2 prior anti-TNFs), and cardiovascular comorbidity at abatacept initiation (0.48 [0.28, 0.83], p = 0.009) were associated with lower risk of abatacept discontinuation. Patients in Greece and Italy were less likely to discontinue abatacept than patients in Germany and Canada (Greece: 0.30 [0.16, 0.58]; Italy: 0.50 [0.33, 0.76]; Canada: 1.04 [0.78, 1.40], p &lt; 0.001 versus Germany). Conclusions: Real-world prognostic factors for abatacept retention include anti-CCP positivity and fewer prior anti-TNF failures. Differences in retention rates between countries may reflect differences in healthcare systems. The finding that abatacept has potential advantages in patients with cardiovascular comorbidities needs to be confirmed in further research