Towards Better Fairness-Utility Trade-off: A Comprehensive Measurement-Based Reinforcement Learning Framework

Machine learning is widely used to make decisions with societal impact such as bank loan approving, criminal sentencing, and resume filtering. How to ensure its fairness while maintaining utility is a challenging but crucial issue. Fairness is a complex and context-dependent concept with over 70 different measurement metrics. Since existing regulations are often vague in terms of which metric to use and different organizations may prefer different fairness metrics, it is important to have means of improving fairness comprehensively. Existing mitigation techniques often target at one specific fairness metric and have limitations in improving multiple notions of fairness simultaneously. In this work, we propose CFU (Comprehensive Fairness-Utility), a reinforcement learning-based framework, to efficiently improve the fairness-utility trade-off in machine learning classifiers. A comprehensive measurement that can simultaneously consider multiple fairness notions as well as utility is established, and new metrics are proposed based on an in-depth analysis of the relationship between different fairness metrics. The reward function of CFU is constructed with comprehensive measurement and new metrics. We conduct extensive experiments to evaluate CFU on 6 tasks, 3 machine learning models, and 15 fairness-utility measurements. The results demonstrate that CFU can improve the classifier on multiple fairness metrics without sacrificing its utility. It outperforms all state-of-the-art techniques and has witnessed a 37.5% improvement on average

Probing the endosperm gene expression landscape in Brassica napus

<p>Abstract</p> <p>Background</p> <p>In species with exalbuminous seeds, the endosperm is eventually consumed and its space occupied by the embryo during seed development. However, the main constituent of the early developing seed is the liquid endosperm, and a significant portion of the carbon resources for the ensuing stages of seed development arrive at the embryo through the endosperm. In contrast to the extensive study of species with persistent endosperm, little is known about the global gene expression pattern in the endosperm of exalbuminous seed species such as crucifer oilseeds.</p> <p>Results</p> <p>We took a multiparallel approach that combines ESTs, protein profiling and microarray analyses to look into the gene expression landscape in the endosperm of the oilseed crop <it>Brassica napus</it>. An EST collection of over 30,000 entries allowed us to detect close to 10,000 unisequences expressed in the endosperm. A protein profile analysis of more than 800 proteins corroborated several signature pathways uncovered by abundant ESTs. Using microarray analyses, we identified genes that are differentially or highly expressed across all developmental stages. These complementary analyses provided insight on several prominent metabolic pathways in the endosperm. We also discovered that a transcription factor <it>LEAFY COTYLEDON </it>(<it>LEC1</it>) was highly expressed in the endosperm and that the regulatory cascade downstream of <it>LEC1 </it>operates in the endosperm.</p> <p>Conclusion</p> <p>The endosperm EST collection and the microarray dataset provide a basic genomic resource for dissecting metabolic and developmental events important for oilseed improvement. Our findings on the featured metabolic processes and the <it>LEC1 </it>regulatory cascade offer new angles for investigation on the integration of endosperm gene expression with embryo development and storage product deposition in seed development.</p

Mining biological information from 3D short time-series gene expression data: the OPTricluster algorithm

<p>Abstract</p> <p>Background</p> <p>Nowadays, it is possible to collect expression levels of a set of genes from a set of biological samples during a series of time points. Such data have three dimensions: gene-sample-time (GST). Thus they are called 3D microarray gene expression data. To take advantage of the 3D data collected, and to fully understand the biological knowledge hidden in the GST data, novel subspace clustering algorithms have to be developed to effectively address the biological problem in the corresponding space.</p> <p>Results</p> <p>We developed a subspace clustering algorithm called Order Preserving Triclustering (OPTricluster), for 3D short time-series data mining. OPTricluster is able to identify 3D clusters with coherent evolution from a given 3D dataset using a combinatorial approach on the sample dimension, and the order preserving (OP) concept on the time dimension. The fusion of the two methodologies allows one to study similarities and differences between samples in terms of their temporal expression profile. OPTricluster has been successfully applied to four case studies: immune response in mice infected by malaria (<it>Plasmodium chabaudi</it>), systemic acquired resistance in <it>Arabidopsis thaliana</it>, similarities and differences between inner and outer cotyledon in <it>Brassica napus </it>during seed development, and to <it>Brassica napus </it>whole seed development. These studies showed that OPTricluster is robust to noise and is able to detect the similarities and differences between biological samples.</p> <p>Conclusions</p> <p>Our analysis showed that OPTricluster generally outperforms other well known clustering algorithms such as the TRICLUSTER, gTRICLUSTER and K-means; it is robust to noise and can effectively mine the biological knowledge hidden in the 3D short time-series gene expression data.</p

Effects of high-intensity interval training, moderate-intensity continuous training, and guideline-based physical activity on cardiovascular metabolic markers, cognitive and motor function in elderly sedentary patients with type 2 diabetes (HIIT-DM): a protocol for a randomized controlled trial

Background and objectiveSedentary behavior is of increasing concern in older patients with type 2 diabetes mellitus (T2DM) due to its potential adverse effects on cardiovascular health, cognitive function, and motor function. While regular exercise has been shown to improve the health of individuals with T2DM, the most effective exercise program for elderly sedentary patients with T2DM remains unclear. Therefore, the objective of this study was to assess the impact of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and guideline-based physical activity programs on the cardiovascular health, cognitive function, and motor function of this specific population.MethodsThis study will be a randomized, assessor-blind, three-arm controlled trial. A total of 330 (1:1:1) elderly sedentary patients diagnosed with T2DM will be randomly assigned the HIIT group (10 × 1-min at 85–95% peak HR, intersperse with 1-min active recovery at 60–70% peak HR), MICT (35 min at 65–75% peak HR), and guideline-based group (guideline group) for 12 weeks training. Participants in the guideline group will receive 1-time advice and weekly remote supervision through smartphones. The primary outcomes will be the change in glycosylated hemoglobin (HbA1c) and brain-derived neurotrophic factor (BDNF) after 12-weeks. Secondary outcomes will includes physical activity levels, anthropometric parameters (weight, waist circumference, hip circumference, and body mass index), physical measurements (fat percentage, muscle percentage, and fitness rate), cardiorespiratory fitness indicators (blood pressure, heart rate, vital capacity, and maximum oxygen), biochemical markers (high-density lipoprotein, low-density lipoprotein, triglycerides, total cholesterol, and HbA1c), inflammation level (C-reactive protein), cognitive function (reaction time and dual-task gait test performance), and motor function (static balance, dynamic balance, single-task gait test performance, and grip strength) after 12 weeks.DiscussionThe objective of this study is to evaluate the effect of 12 weeks of HIIT, MICT, and a guideline-based physical activity program on elderly sedentary patients diagnosed with T2DM. Our hypothesis is that both HIIT and MICT will yield improvements in glucose control, cognitive function, cardiopulmonary function, metabolite levels, motor function, and physical fitness compared to the guideline group. Additionally, we anticipate that HIIT will lead to greater benefits in these areas. The findings from this study will provide valuable insights into the selection of appropriate exercise regimens for elderly sedentary individuals with T2DM.Ethics and disseminationThis study has been approved by the Ethics Review Committee of the Reproductive Hospital Affiliated with China Medical University (approval number: 202203). Informed consent will be obtained from all participants or their guardians. Upon completion, the authors will submit their findings to a peer-reviewed journal or academic conference for publication.Clinical trial registrationChinese Clinical Trial Registry, identifier ChiCTR2200061573

Separation of graphene oxides of different sizes by multi-layer dialysis and anti-friction and lubrication performance

GO was diffused into different size samples by dialysis. The experimental results showed that the GO in uniform size had better anti-friction and lubrication effects

Spatial and temporal variation in the avian-frugivore assemblage of Prunus mahaleb: patterns and consequences

The patterns of spatial and temporal sariatton in the species richness and relative abundance of frtigivorous birds that consume truits and disperse seeds of Pntoms otoltaleb (Rosaceae) were studied in two Southeastern Spain populations and compared svilh previous information from 4 sites. 3 of them iii Northwestern Spain. Data for S study years iii one population are usenl to assess temporal variation in tins trugivore assemblage. Species richness of local bird assemblages ranged between 6 and 26 species. Thrushes. redstarts, and warhlers were the main seed dispersers among a total of 31 species recorded for all sites pooled, and together account for 82% of the feeding records. Chaffinches and tits. acting as pulp consumers, were also important in at least tsvo highland assemblages. The propoi tional similarities for pai ‘wise compansoits among assemblages averaeed 0.3 I ± 1). 16. indicative of significant local s ariatioii iii assemblage eooipositiimn. Hoss ever, most differences ss crc bets ecu assemblages from the two geographic regions, with pairsvi se si nO larities between assernbl ages within a gis en region being significant. The relative importance of legitimate seed dispersers. pulp consumers, and seed predators varied significantly among sites, this variation being more pronounced than variability amoni! years ss ithin a site. The matrix of proptir i on il 5 iii I an ty among sites showed t. structured pat tern and w as strong1 correlated ss t th a matrix ol geographic di stance anioug them, The frugi vorous bt ml isiting P. oinlioleb show cr1 significant sintilarit and constancy among sites within a region and ataong ‘ears within a site. bitt subtle sat iations in the relative importance ud legitimate seed dispersers versus non-disperser species had meastirable effects on seed dispersal Average fruit removal and seed dispersal efficiency for oidis idual trees increased in sites or years is ith greater relative importance of legitimate seed dispersers in the frugivore assemblages. These variations and their potential effects could be very difficult to detect in short term studies hut mas has e demographic and es olutionary implications in this plant—frugivore interactionPeer reviewe