6,549 research outputs found
Supplier selection using a hybrid model for 3C industry
Supplier selection is a good strategy for firms that can reduce operating costs and improve competitiveness for computer, communication and consumer electronics (3C) industry. The major aim of this research is to build a systematic approach for establishing a supplier selection model, and then prioritize improvement criteria in order to best supply chain management. The study proposed a hybrid approach by using the interpretive structural modeling (ISM) method to deal with the interrelationship among criteria, and the analytic network process (ANP) method is employed to recognize the criteria of supplier selection and evaluate with respect to environmental competency for the case of Taiwan's 3C industry. The study shows that the proposed model could be an effective and efficient decision-making tool that can be easily extended to other contexts. Especially, it has provided decision-makers and researchers with better understanding of the differences in supplier selection activity needs and specific management interventions by examining these criteria
Observation of superradiance in a phase fluctuating dipolar Bose-Einstein condensate
Despite the extensive study of matter-wave superradiance in a Bose-Einstein
condensate (BEC) using its unique coherence property, the controllability of
superradiant process has remained limited in the previous studies exploiting a
phase-coherent condensate with isotropic contact interactions. Here, we combine
tunable s-wave scattering with dipolar interactions in a BEC of Er
atoms wherein the asymmetry and threshold of superradiance are independently
controlled. By changing the s-wave scattering length near the Feshbach
resonance, we tune the superradiance threshold with increasing phase
fluctuations. In contrast to collective light scattering from a condensate only
with contact interactions, we observe an asymmetric superradiant peak in a
dipolar BEC by changing the direction of external magnetic field. This results
from the anisotropic excitation spectrum induced by the dipole-dipole
interaction. Our observation is expected to bring forth unprecedented
application of matter-wave optics leading to controlled emission of matter
wave.Comment: 6 pages, 6 figure
Magnetic field regression using artificial neural networks for cold atom experiments
Accurately measuring magnetic fields is essential for magnetic-field
sensitive experiments in fields like atomic, molecular, and optical physics,
condensed matter experiments, and other areas. However, since many experiments
are conducted in an isolated vacuum environment that is inaccessible to
experimentalists, it can be challenging to accurately determine the magnetic
field. Here, we propose an efficient method for detecting magnetic fields with
the assistance of an artificial neural network (NN). Instead of measuring the
magnetic field directly at the desired location, we detect magnetic fields at
several surrounding positions, and a trained NN can accurately predict the
magnetic field at the target location. After training, we achieve a relative
error of magnetic field magnitude (magnitude of error over the magnitude of
magnetic field) below 0.3, and we successfully apply this method to our
erbium quantum gas apparatus. This approach significantly simplifies the
process of determining magnetic fields in isolated vacuum environments and can
be applied to various research fields across a wide range of magnetic field
magnitudes.Comment: 7 pages, 4 figure
Identification of single nucleotide polymorphism markers associated with resistance to bruchids (Callosobruchus spp.) in wild mungbean (Vigna radiata var. sublobata) and cultivated V. radiata through genotyping by sequencing and quantitative trait locus analysis
Interval mapping of bruchid resistance on physical maps of populations TC1966 x NM94 and V2802. (DOCX 14Â kb
Influence of typical environments on quantum processes
We present the results of studying the influence of different environmental
states on the coherence of quantum processes. We choose to discuss a simple
model which describe two electronic reservoirs connected through tunneling via
a resonant state. The model could, e.g., serve as an idealization of inelastic
resonant tunneling through a double barrier structure. We develop Schwinger's
closed time path formulation of non-equilibrium quantum statistical mechanics,
and show that the influence of the environment on a coherent quantum process
can be described by the value of a generating functional at a specific force
value, thereby allowing for a unified discussion of destruction of phase
coherence by various environmental states: thermal state, classical noise, time
dependent classical field, and a coherent state. The model allows an extensive
discussion of the influence of dissipation on the coherent quantum process, and
expressions for the transmission coefficient are obtained in the possible
limits.Comment: 46 pages, 11 post script figures. Accepted for publication in
Physical Review
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells
2-Phenyl-4-quinolone series compounds have exhibited growth inhibitory influence on several human cancer cell lines. In this study, we investigated the effects of 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) on viability, cell cycle and apoptotic cell death which occurred in different leukemia cell lines (HL-60, U937 and K562) in a dose- and time-dependent manner, but which did not obviously impair the viability of normal human umbilical vein endothelial cells (HUVEC) in vitro. The approximate IC50 was 103.26 ± 4.59 nM for a 48 h treatment in HL-60 cells. Cell cycle analysis showed that 100 nM Smh-3 induced signi-ficant G2/M arrest in examined cells. Within 0, 12, 24 and 48 h of treatment, Smh-3 inhibited CDK1 activity and decreased protein levels of CDK1, cyclin A and cyclin B. Smh-3-induced chromatin condensation and DNA fragmentation were determined by DAPI and TUNEL staining. Cell apoptosis was significantly reduced after pretreatment with a pan-caspase inhibitor (Z-VAD-fmk) and results indicated that Smh-3-induced apoptosis was mainly mediated by activation of the caspase cascade in HL-60 cells. Results from colorimetric assays and Western blot analysis indicated that activities of caspase-9, -7 and -3 were promoted in Smh-3-treated HL-60 cells during cell apoptosis. Smh-3-induced apoptosis in HL-60 cells was accompanied by an apparent increase in ROS production, and protein levels of cytosolic cytochrome c, apoptotic protease activating factor-1 (Apaf-1) and apoptosis-inducing factor (AIF). Strikingly, Smh-3 induced apoptosis in HL-60 cells by simultaneously suppressing protein levels of AKT, p-AKT, p-mTOR and p-BAD and inducing BAD protein levels. Taken together, we conclude that Smh-3 acts against leukemia cells in vitro via G2/M phase arrest, down-regulation of AKT activity and induction of mitochondrial-dependent apoptotic pathways
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