Flow equations in generalized braneworld scenarios

We discuss the flow equations in the context of general braneworld cosmologies with a modified Friedmann equation, for either an ordinary scalar field or a Dirac-Born-Infeld tachyon as inflaton candidates. The 4D, Randall-Sundrum, and Gauss-Bonnet cases are compared, using the patch formalism which provides a unified description of these models. The inflationary dynamics is described by a tower of flow parameters that can be evolved in time to select a particular subset of points in the space of cosmological observables. We analyze the stability of the fixed points in all the cosmologies (our results in the 4D case already extending those in the literature). Numerical integration of the flow equations shows that the predictions of the Gauss-Bonnet braneworld differ significantly as compared to the Randall-Sundrum and 4D scenarios, whereas tachyon inflation gives tensor perturbations smaller than those in the presence of a normal scalar field. These results are extended to the realization of a noncommutative space-time preserving maximal symmetry. In this case the tensor-to-scalar signal is unchanged, while blue-tilted spectra are favoured.Comment: 10 pages RevTeX4 with 3 figures included. Matches published version. Note change of title from original submissio

R^2 Corrections for 5D Black Holes and Rings

We study higher-order corrections to two BPS solutions of 5D supergravity, namely the supersymmetric black ring and the spinning black hole. Due in part to our current relatively limited understanding of F-type terms in 5D supergravity, the nature of these corrections is less clear than that of their 4D cousins. Effects of certain $R^2$ terms found in Calabi-Yau compactification of M-theory are specifically considered. For the case of the black ring, for which the microscopic origin of the entropy is generally known, the corresponding higher order macroscopic correction to the entropy is found to match a microscopic correction, while for the spinning black hole the corrections are partially matched to those of a 4D $D0-D2-D6$ black hole.Comment: 9 page

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Emerging evidence suggests that the T helper 17 (T(H)17) subset of αβ T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the αvβ8 integrin on dendritic cells did not generate T(H)17 cells in the lung and were protected from airway hyper-responsiveness in response to house dust mite and ovalbumin sensitization and challenge. Because loss of T(H)17 cells inhibited airway narrowing without any obvious effects on airway inflammation or epithelial morphology, we examined the direct effects of T(H)17 cytokines on mouse and human airway smooth muscle function. Interleukin-17A (IL-17A), but not IL-17F or IL-22, enhanced contractile force generation of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor κ light-chain enhancer of activated B cells (NF-κB)-ras homolog gene family, member A (RhoA)-Rho-associated coiled-coil containing protein kinase 2 (ROCK2) signaling cascade. Mice lacking integrin αvβ8 on dendritic cells showed impaired activation of this pathway after ovalbumin sensitization and challenge, and the diminished contraction of the tracheal rings in these mice was reversed by IL-17A. These data indicate that the IL-17A produced by T(H)17 cells contributes to allergen-induced airway hyper-responsiveness through direct effects on airway smooth muscle

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

This work was funded jointly by the Biotechnology and Biological Sciences Research Council, the Department for Environment, Food and Rural Affairs, the Natural Environment Research Council, the Scottish Government, and The Wellcome Trust, under the Insect Pollinators Initiative (United Kingdom) Grant BB/ 1000313/1 (to C.N.C.).The global decline in the abundance and diversity of insect pollinators could result from habitat loss, disease, and pesticide exposure. The contribution of the neonicotinoid insecticides (e.g., clothianidin and imidacloprid) to this decline is controversial, and key to understanding their risk is whether the astonishingly low levels found in the nectar and pollen of plants is sufficient to deliver neuroactive levels to their site of action: the bee brain. Here we show that bumblebees (Bombusterrestris audax) fed field levels [10 nM, 2.1 ppb (w/w)] of neonicotinoid accumulate between 4 and 10 nM in their brains within 3 days. Acute (minutes) exposure of cultured neurons to 10 nM clothianidin, but not imidacloprid, causes a nicotinic acetylcholine receptor-dependent rapid mitochondrial depolarization. However, a chronic (2 days) exposure to 1 nM imidacloprid leads to a receptor-dependent increased sensitivity to a normally innocuous level of acetylcholine, which now also causes rapid mitochondrial depolarization in neurons. Finally, colonies exposed to this level of imidacloprid show deficits in colony growth and nest condition compared with untreated colonies. These findings provide a mechanistic explanation for the poor navigation and foraging observed in neonicotinoid treated bumblebee colonies.Publisher PDFPeer reviewe

STM studies of epitaxial graphene

This article reviews the use of scanning tunneling microscopy (STM) and scanning tunneling spectroscopy (STS) to characterize the physical and electronic properties of epitaxial graphene. Topographical variations revealed by STM allow the determination of the number of graphene layers and the detection of lattice mismatch between the graphene and the substrate, as well as rotational disorder. STS allows the local electronic characterization of graphene. STM/STS can also be used to perform local studies of graphene modification through processes such as atomic/molecular adsorption and intercalation

Percutaneous endoscopic gastrostomy site metastasis from head and neck squamous cell carcinoma: case series and literature review

Objectives To present our experience with head and neck squamous cell carcinoma (HNSCC) seeding of percutaneous endoscopic gastrostomy (PEG) sites and to review all reported cases to identify risk factors and develop strategies for complication avoidance. Materials and methods The records of 4 patients with PEG site metastasis from HNSCC were identified from the authors’ institution. Thirty-eight further cases were reviewed following a PubMed search and evaluation of references in pertinent articles. Results Review of 42 cases revealed the average time from PEG to diagnosis of metastatic disease to be 8 months. Average time to death from detection of PEG disease was 5.9 months. One-year survival following PEG metastasis was 35.5% with an overall mortality of 87.1%. Conclusion PEG site metastatic disease portends a poor prognosis. Early detection and aggressive therapy may provide a chance of cure. Changes in PEG technique or in timing of adjunctive therapies are possible avenues in further research to prevent this complication

Molecular Communication for Quorum Sensing Inspired Cooperative Drug Delivery

A cooperative drug delivery system is proposed, where quorum sensing (QS), a density-dependent bacterial behavior coordination mechanism, is employed by synthetic bacterium-based nanomachines (B-NMs) for controllable drug delivery. In our proposed system, drug delivery is only triggered when there are enough QS molecules, which in turn only happens when there are enough B-NMs. This makes the proposed system can be used to achieve a high release rate of drug molecules from a high number of B-NMs when the population density of B-NMs may not be known. Analytical expressions for i) the expected activation probability of the B-NM due to randomly-distributed B-NMs and ii) the expected aggregate absorption rate of drug molecules due to randomly-distributed QS activated B-NMs are derived. Analytical results are verified by particle-based simulations. The derived results can help to predict and control the impact of environmental factors (e.g. diffusion coefficient and degradation rate) on the absorption rate of drug molecules since rigorous diffusion-based molecular channels are considered. Our results show that the activation probability at the B-NM increases as this B-NM is located closer to the center of the B-NM population and the aggregate absorption rate of the drug molecules non-linearly increases as the population density increases.Comment: 9 pages; 9 figure