Implementation of ACTS for STCF track reconstruction

With an electron-positron collider operating at center-of-mass-energy 2-7 GeV and a peak luminosity above $0.5\times10^{35} cm^{-2} s^{-1}$, the STCF physics program will provide an unique platform for in-depth studies of hadron structure and non-perturbative strong interaction as well as probing new physics beyond the Standard Model in the $\tau$-Charm sector, succeeding the present Beijing Electron-Positron Collider. To fulfill the physics targets and further maximize the physics potential at STCF, the STCF tracking software should have capability to reconstruct charged particles with high efficiency and excellent momentum resolution, especially for the charged particles with low transverse momentum down to 50 MeV. A Common Tracking Software (ACTS) providing a set of detector-independent tracking algorithms is adopted for reconstructing charged tracks with the information of two sub-detectors, a $\mu$RWELL-based inner tracker and a drift chamber, at STCF. This is the first demonstration of ACTS for a drift chamber. The implementation details and performance of track reconstruction are presented.Comment: 14 pages, 7 figure

Efficient EGFR signaling and dorsal–ventral axis patterning requires syntaxin dependent Gurken trafficking

AbstractVesicle trafficking plays a crucial role in the establishment of cell polarity in various cellular contexts, including axis-pattern formation in the developing egg chamber of Drosophila. The EGFR ligand, Gurken (Grk), is first localized at the posterior of young oocytes for anterior–posterior axis formation and later in the dorsal anterior region for induction of the dorsal–ventral (DV) axis, but regulation of Grk localization by membrane trafficking in the oocyte remains poorly understood. Here, we report that Syntaxin 1A (Syx1A) is required for efficient trafficking of Grk protein for DV patterning. We show that Syx1A is associated with the Golgi membrane and is required for the transportation of Grk-containing vesicles along the microtubules to their dorsal anterior destination in the oocyte. Our studies reveal that the Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during DV patterning

Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing”

A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Indeed, the “Tegaderm” itself can serve as a dressing film to isolate the wound bed with outside environments while the “splinting effect” is mainly achieved by adding silicone splints around the wound. Considering the unique properties of silicone splints and “Tegaderm,” our experimental group propose an alternative method named “combined-suturing” technique that is not only suturing the silicone splints but also securing the “Tegaderm” around the wound. The specific reasons and operative procedures are explained in detail in this letter

Performance of Track Reconstruction at STCF Using ACTS

The STCF physics program will provide an unique platform for studies of hadron physics, strong interactions and searches for new physics beyond the Standard Model in the τ-charm region. To deliver those physics programs, the charged particles at STCF are required to be reconstructed with high efficiency and excellent momentum resolution. In particular, charged particles with transverse momentum down to 50 MeV are required to be reconstructed. The tracking performance at STCF is studied using A Common Tracking Software (ACTS) based on the information of the STCF tracking system, a µRWELL-based inner tracker and a drift chamber. We demonstrated the first application of ACTS for a drift chamber. The implementation and tracking performance are presented

Label-free timing analysis of modularized nuclear detectors with physics-constrained deep learning

Pulse timing is an important topic in nuclear instrumentation, with far-reaching applications from high energy physics to radiation imaging. While high-speed analog-to-digital converters become more and more developed and accessible, their potential uses and merits in nuclear detector signal processing are still uncertain, partially due to associated timing algorithms which are not fully understood and utilized. In this paper, we propose a novel method based on deep learning for timing analysis of modularized nuclear detectors without explicit needs of labelling event data. By taking advantage of the inner time correlation of individual detectors, a label-free loss function with a specially designed regularizer is formed to supervise the training of neural networks towards a meaningful and accurate mapping function. We mathematically demonstrate the existence of the optimal function desired by the method, and give a systematic algorithm for training and calibration of the model. The proposed method is validated on two experimental datasets. In the toy experiment, the neural network model achieves the single-channel time resolution of 8.8 ps and exhibits robustness against concept drift in the dataset. In the electromagnetic calorimeter experiment, several neural network models (FC, CNN and LSTM) are tested to show their conformance to the underlying physical constraint and to judge their performance against traditional methods. In total, the proposed method works well in either ideal or noisy experimental condition and recovers the time information from waveform samples successfully and precisely.Comment: 25 pages, 10 figure

Using combination of lifting wavelet and multiclass SVM based on global optimization class strategy for fault pattern identification

This paper presents a new method based on lifting wavelet for obtaining a fast multiclass SVM classification based on global optimization class strategy for fault diagnosis of roller bearing. Decision making was performed in two stages: feature extraction by computing the lifting wavelet coefficients and classification using the multiclass SVM classifiers trained on the extracted features. Experiments demonstrate that in comparison to discrete wavelet transform the lifting wavelet feature extraction can speed up the identification phase as well as achieve higher accuracy of multiclass SVM that is based on global optimization class strategy. Experimental results also reveal that the proposed multiclass SVM of global optimization is better than strategy of one against one and DAGSVM

Seroprevalence of enterovirus 71 and no evidence of crossprotection of enterovirus 71 antibody against the other enteroviruses in kindergarten children in Taipei city

Background/PurposeEnterovirus 71 (EV71) infection may cause severe neurological and cardiopulmonary complications, especially in preschool children. This study is to investigate the seroprevalence and seroconversion of EV71, and the crossprotection of EV71 antibody against other enteroviruses among kindergarteners.MethodsOverall 228 children in a public kindergarten were enrolled during two academic years, 2006 and 2007, in Taipei, Taiwan and we measured their EV71 neutralizing antibody. When the participants had herpangina; hand, foot and mouth disease (HFMD); febrile illness or respiratory symptoms, throat swabs were sampled and processed for viral culture and enterovirus real-time reverse transcriptase polymerase chain reaction (RT-PCR). Questionnaires, completed by the participants’ guardians, surveyed the history of allergy and annual incidence of symptoms related to enterovirus infection.ResultsSeropositive rates of EV71 were 20% (32/163) in 2006 and 6% (4/65) in 2007. The rate of EV71 seropositivity increased with age (p < 0.01) in 2006 but it did not differ between genders (p = 0.14). No seroconversion was observed from 2006 to 2007. Herpangina occurred in 64% of children with EV71 seropositivity and 48% of those without EV71 antibodies (p = 0.12). Non-71 enterovirus infection, confirmed by viral study, occurred in 53% (19/36) of the EV71-seropositive children and in 53% (102/192) of EV71-seronegative children (p = 0.89). No participants had EV71 infection during the study period.ConclusionEV71 did not frequently circulate in Taipei City from September 2006 to June 2008. Presence of EV71 neutralizing antibody was not associated with lower incidence of enterovirus infection caused by non-71 serotypes

Household Transmission of Pandemic (H1N1) 2009 Virus, Taiwan

During August–November 2009, to investigate disease transmission within households in Taiwan, we recruited 87 pandemic (H1N1) 2009 patients and their household members. Overall, pandemic (H1N1) 2009 virus was transmitted to 60 (27%) of 223 household contacts. Transmission was 4× higher to children than to adults (61% vs. 15%; p<0.001)