Re-criticism of Geomantic Omen in Modern Design from the Perspective of Data Analysis

Geomantic omen is both strange and familiar to the contemporary people. It is not only a part of the traditional Chinese culture, but also contains the contradictions and disputes in Chinese long history of thought, practice and theory. This article is based on the context of modern design, discuss the reason of the Geomantic omen cannot be the key factors of modern design from three perspectives, including research trend, discipline development, practice creation. Through the summary of data, typical cases, and geomantic theory, it is believed that modern geomantic research should be based on rational evaluation and theoretical research. Except that, geomancy can be study not only by using modern science and technology, but also through transcending the ideological level. Finally, the idea of the future development of geomantic is set up for the re-thinking and re-exploration of the contemporary research

HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma

Tumor-associated antigens (TAAs) have been the most actively employed targets in the clinical diagnosis and treatment of human carcinoma, such as PSA in the diagnosis of prostate cancer and NY-ESO-1 in the immunotherapy of melanoma and other cancers. However, identification of TAAs has often been hampered by the complicated and laborsome laboratory procedures. In order to accelerate the process of tumor antigen discovery, and thereby improve diagnosis and treatment of human carcinoma, we have made an effort to establish a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with potential TAAs identified by in silico computing (). Tumor specificity was chosen as the core of tumor antigen evaluation, together with other relevant clues. Various platforms of gene expression, including microarray, expressed sequence tag and SAGE data, were processed and integrated by several penalty algorithms. A total of 3518 potential TAAs have been included in the database, which is freely available to academic users. As far as we know, this database is the first one addressing human potential TAAs, and the first one integrating various kinds of expression platforms for one purpose

Therapeutic Ultrasound: Osteoarthritis Symptom-Modification and Potential for Disease Modification

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. While joint replacement surgery is a common treatment option for end-stage disease, non-surgical management is critical for preventing disability and maintaining quality of life. Although therapeutic ultrasound, which applies mechanical and may also apply thermal energy in the form of sound waves, is widely used to treat various musculoskeletal disorders such as bone fractures, tendinopathy, and muscle contusions, its symptom- and disease-modifying effects on osteoarthritis have not been clearly demonstrated. Recent clinical evidence indicates therapeutic ultrasound is capable of relieving OAassociated pain and improving function of diseased joints. Furthermore, in vitro and in vivo studies are beginning to emerge which suggest ultrasound may exert chondroprotection, such as enhancing anabolic activity, suppressing proteolytic enzyme-mediated degradation of the cartilage matrix, preventing chondrocyte apoptosis and modifying the endocrinology of adipose tissue that may potentially contribute to OA disease initiation and progression. Therefore, ultrasound may have great potential to serve as an effective and non-invasive therapeutic treatment for osteoarthritis

An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy

PURPOSE:Recent studies have shown that a new generation of synthetic agonist of Toll-like receptor (TLR) 9 consisting a 3'-3'-attached structure and a dCp7-deaza-dG dinucultodie shows more potent immunostimulatory effects in both mouse and human than conventional CpG oligonucleotides. Radiation therapy (RT) provides a source of tumor antigens that are released from dying, irradiated, tumor cells without causing systemic immunosuppression. We, therefore, examined effect of combining RT with a designer synthetic agonist of TLR9 on anti-tumoral immunity, primary tumor growth retardation and metastases in a murine model of lung cancer. METHODS:Grouped C57BL/6 and congenic B cell deficient mice (B(-/-)) bearing footpad 3LL tumors were treated with PBS, TLR9 agonist, control oligonucelotide, RT or the combination of RT and TLR9 agonist. Immune phenotype of splenocytes and serum IFN-γ and IL-10 levels were analyzed by FACS and ELISA, 24 h after treatment. Tumor growth, lung metastases and survival rate were monitored and tumor specific antibodies in serum and deposition in tumor tissue were measured by ELISA and immunofluorescence. RESULTS:TLR9 agonist expanded and activated B cells and plasmacytoid dendritic cells in wild-type mice and natural killer DCs (NKDCs) in B cell-deficient (B(-/-)) mice bearing ectopic Lewis lung adenocarcinoma (3LL). Combined RT with TLR9 agonist treatment inhibited 3LL tumor growth in both wild type and B(-/-) mice. A strong tumor-specific humoral immune response (titer: 1/3200) with deposition of mouse IgG auto-antibodies in tumor tissue were found in wildtype mice, whereas the number of tumor infiltrating NKDCs increased in B(-/-) mice following RT+ TLR9 agonist therapy. Furthermore, mice receiving combination therapy had fewer lung metastases and a higher survival than single treatment cohorts. CONCLUSIONS:Combination therapy with TLR9 agonist and RT induces systemic anti-tumoral humoral response, augments tumoral infiltration of NKDCs, reduces pulmonary metastases and improves survival in a murine model of 3LL cancer

Using Dynamic Rheology to Explore the Microstructure and Stiffening of Cementitious Mixtures

199 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.The cement paste and the wollastonite pastes made from pore solutions extracted from cement pastes both vary with time according to a power-law, and the exponents are approximately the same. Stiffening of cement paste in the first hour appears to be due to increase in ionic strength by hydration.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Re-criticism of Geomantic Omen in Modern Design from the Perspective of Data Analysis

Geomantic omen is both strange and familiar to the contemporary people. It is not only a part of the traditional Chinese culture, but also contains the contradictions and disputes in Chinese long history of thought, practice and theory. This article is based on the context of modern design, discuss the reason of the Geomantic omen cannot be the key factors of modern design from three perspectives, including research trend, discipline development, practice creation. Through the summary of data, typical cases, and geomantic theory, it is believed that modern geomantic research should be based on rational evaluation and theoretical research. Except that, geomancy can be study not only by using modern science and technology, but also through transcending the ideological level. Finally, the idea of the future development of geomantic is set up for the re-thinking and re-exploration of the contemporary research

Effects of Teaching Behaviors on the Effectiveness of Classroom Learning Time

Vocational and technical higher education in China has made great progress. However, classroom learning inefficiency is still observed. Based on the composition theory of classroom instructional time and the characteristics of classroom teaching in vocational and technical colleges, evaluation indexes of the effectiveness of classroom learning time were proposed in this study, and the effects of teaching behaviors on the effectiveness of the classroom learning time were analyzed through the observation on teaching behaviors and learning efficiency. Using the classroom teaching of "equivalence calculation in engineering economy" in a vocational and technical college in Chongqing, China as the subject, the classroom observation results were given, while the effects of frequency, cumulative time and the essence of teaching behaviors on the average value of learning time effectiveness (AEVp) and learning effectiveness per unit time (EV) were analyzed. Results show that the longer the time spent on a teaching behavior, the greater the AEVp would be, while EV differs, and "questioning"-typed teaching behaviors usually had positive effects on EV. Results indicate that the conversion of reasonable intervals between teaching behaviors helps to improve EV, and arrangement of personalized learning tasks and the strategies of answering questions need to be taken seriously. This study revealed the relationship between teaching behaviors and the effectiveness of classroom learning time, which may provide the evidence for optimizing instructional design and provide a path to fulfill the personalized learning needs

THE TIMELINESS OF ASYNCHRONOUS PACKET MULTIPLEXING IN SWITCHED ETHERNET

International Telemetering Conference Proceedings / October 18-21, 2004 / Town & Country Resort, San Diego, CaliforniaPowered by single-segment switched interconnection, Ethernet can be used in time-critical data acquisition applications. Unlike synchronous time division multiple access, asynchronous packet streams result in congestions and uncertain multiplexing delays. With the delay analysis in the worst case and probabilistic guaranteeing conditions, we restrict the packet-sizes, intervals or traffic burstiness a priori to regulate delay deviations within acceptable scales. Some methods of combinatorics and stochastic theory, e.g. Cumulant Generating Function and the Large Deviation Principle, are used and verified by some simulation-based computations. The influence of time varying delay for telemetry applications is also discussed in some sense.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection

Trip Mining and Recommendation from Geo-tagged Photos

Abstract-Trip planning is generally a very time-consuming task due to the complex trip requirements and the lack of convenient tools/systems to assist the planning. In this paper, we propose a travel path search system based on geo-tagged photos to facilitate tourists' trip planning, not only for where to visit but also how to visit. The large scale geo-tagged photos that are publically available on the web make this system possible, as geo-tagged photos encode rich travel-related metadata and can be used to mine travel paths from previous tourists. In this work, about 20 million geo-tagged photos were crawled from Panoramio.com. Then a substantial number of travel paths are minded from the crawled geo-tagged photos. After that, a search system is built to index and search the paths, and the Sparse Chamfer Distance is proposed to measure the similarity of two paths. The search system supports various types of queries, including (1) a destination name; (2) a user-specified region on the map; (3) some userpreferred locations. Based on the search system, users can interact with the system by specifying a region or several interest points on the map to find paths. Extensive experiments show the effectiveness of the proposed framework