3,649 research outputs found
Diaquabis(4-methylbenzoato-κO)zinc(II)
The Zn atom in the title mononuclear complex, [Zn(C8H7O2)2(H2O)2], lies on a special position of site symmetry 2. The carboxylate group binds in a monodentate manner so that the geometry is best described as tetrahedral. Adjacent molecules are linked by O—H⋯O hydrogen bonds into a three-dimensional network
N′-(5-Bromo-2-hydroxybenzylidene)-4-nitrobenzohydrazide methanol monosolvate
In the title compound, C14H10BrN3O4·CH4O, the benzohydrazide molecule is nearly planar [maximum deviation = 0.110 (2) Å]. The mean planes of the two benzene rings make a dihedral angle of 8.4 (3)°. In the benzohydrazide molecule, there is an intramolecular O—H⋯N hydrogen bond and the NH group is hydrogen bonded to the methanol solvent molecule. In the crystal, intermolecular O—H⋯O hydrogen bonds involving the methanol solvent molecule link the benzohydrazide molecules to form chains which propagate along the a axis
A study of instability in a miniature flying-wing aircraft in high-speed taxi
AbstractThis study investigates an instability that was observed during high-speed taxi tests of an experimental flying-wing aircraft. In order to resolve the reason of instability and probable solution of it, the instability was reproduced in simulations. An analysis revealed the unique stability characteristics of this aircraft. This aircraft has a rigid connection between the nose wheel steering mechanism and an electric servo, which is different from aircraft with a conventional tricycle landing gear system. The analysis based on simulation results suggests that there are two reasons for the instability. The first reason is a reversal of the lateral velocity of the nose wheel. The second reason is that the moment about the center of gravity created by the lateral friction force from the nose wheel is larger than that from the lateral friction force from the main wheels. These problems were corrected by changing the ground pitch angle. Simulations show that reducing the ground pitch angle can eliminate the instability in high-speed taxi
Poly[diaqua(μ3-1H-benzimidazole-5,6-dicarboxylato-κ4 N 3:O 5,O 6:O 6′)magnesium(II)]
In the title complex, [Mg(C9H4N2O4)(H2O)2]n, the MgII atom is six-coordinated by one N and three O atoms from three different 1H-benzimidazole-5,6-dicarboxylate ligands and two O atoms from two water molecules, forming a slightly distorted octahedral geometry. The ligand links the MgII centres into a three-dimensional network. Extensive N—H⋯O and O—H⋯O hydrogen bonds exist between the ligands and water molecules, stabilizing the crystal structure
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with p38 MAPK signaling is unclear. Therefore, this study investigated the regulation of p38 MAPK by Hsp70 in I/R-induced cardiac injury.MethodsNeonatal rat cardiomyocytes were subjected to oxygen-glucose deprivation for 6 h followed by 2 h reoxygenation (OGD/R), and rats underwent left anterior artery ligation for 30 min followed by 30 min of reperfusion. The p38 MAPK inhibitor (SB203580), Hsp70 inhibitor (Quercetin), and Hsp70 short hairpin RNA (shRNA) were used prior to OGD/R or I/R. Cell viability, lactate dehydrogenase (LDH) release, serum cardiac troponin I (cTnI), [Ca2+]i levels, cell apoptosis, myocardial infarct size, mRNA level of IL-1β and IL-6, and protein expression of Hsp70, phosphorylated p38 MAPK (p-p38 MAPK), sarcoplasmic/endoplasmic reticulum Ca2+-ATPase2 (SERCA2), phosphorylated signal transducer and activator of transcription3 (p-STAT3), and cleaved caspase3 were assessed.ResultsPretreatment with a p38 MAPK inhibitor, SB203580, significantly attenuated OGD/R-induced cell injury or I/R-induced myocardial injury, as evidenced by improved cell viability and lower LDH release, resulted in lower serum cTnI and myocardial infarct size, alleviation of [Ca2+]i overload and cell apoptosis, inhibition of IL-1β and IL-6, and modulation of protein expressions of p-p38 MAPK, SERCA2, p-STAT3, and cleaved-caspase3. Knockdown of Hsp70 by shRNA exacerbated OGD/R-induced cell injury, which was effectively abolished by SB203580. Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.ConclusionsInhibition of Hsp70 aggravates [Ca2+]i overload, inflammation, and apoptosis through regulating p38 MAPK signaling during cardiac I/R injury, which may help provide novel insight into cardioprotective strategies
Chrion: Optimizing Recurrent Neural Network Inference by Collaboratively Utilizing CPUs and GPUs
Deploying deep learning models in cloud clusters provides efficient and
prompt inference services to accommodate the widespread application of deep
learning. These clusters are usually equipped with host CPUs and accelerators
with distinct responsibilities to handle serving requests, i.e. generalpurpose
CPUs for input preprocessing and domain-specific GPUs for forward computation.
Recurrent neural networks play an essential role in handling temporal inputs
and display distinctive computation characteristics because of their high
inter-operator parallelism. Hence, we propose Chrion to optimize recurrent
neural network inference by collaboratively utilizing CPUs and GPUs. We
formulate the model deployment in the CPU-GPU cluster as an NP-hard scheduling
problem of directed acyclic graphs on heterogeneous devices. Given an input
model in the ONNX format and user-defined SLO requirement, Chrion firstly
preprocesses the model by model parsing and profiling, and then partitions the
graph to select execution devices for each operator. When an online request
arrives, Chrion performs forward computation according to the graph partition
by executing the operators on the CPU and GPU in parallel. Our experimental
results show that the execution time can be reduced by 19.4% at most in the
latency-optimal pattern and GPU memory footprint by 67.5% in the memory-optimal
pattern compared with the execution on the GPU
FedALA: Adaptive Local Aggregation for Personalized Federated Learning
A key challenge in federated learning (FL) is the statistical heterogeneity
that impairs the generalization of the global model on each client. To address
this, we propose a method Federated learning with Adaptive Local Aggregation
(FedALA) by capturing the desired information in the global model for client
models in personalized FL. The key component of FedALA is an Adaptive Local
Aggregation (ALA) module, which can adaptively aggregate the downloaded global
model and local model towards the local objective on each client to initialize
the local model before training in each iteration. To evaluate the
effectiveness of FedALA, we conduct extensive experiments with five benchmark
datasets in computer vision and natural language processing domains. FedALA
outperforms eleven state-of-the-art baselines by up to 3.27% in test accuracy.
Furthermore, we also apply ALA module to other federated learning methods and
achieve up to 24.19% improvement in test accuracy.Comment: Accepted by AAAI 202
FedCP: Separating Feature Information for Personalized Federated Learning via Conditional Policy
Recently, personalized federated learning (pFL) has attracted increasing
attention in privacy protection, collaborative learning, and tackling
statistical heterogeneity among clients, e.g., hospitals, mobile smartphones,
etc. Most existing pFL methods focus on exploiting the global information and
personalized information in the client-level model parameters while neglecting
that data is the source of these two kinds of information. To address this, we
propose the Federated Conditional Policy (FedCP) method, which generates a
conditional policy for each sample to separate the global information and
personalized information in its features and then processes them by a global
head and a personalized head, respectively. FedCP is more fine-grained to
consider personalization in a sample-specific manner than existing pFL methods.
Extensive experiments in computer vision and natural language processing
domains show that FedCP outperforms eleven state-of-the-art methods by up to
6.69%. Furthermore, FedCP maintains its superiority when some clients
accidentally drop out, which frequently happens in mobile settings. Our code is
public at https://github.com/TsingZ0/FedCP.Comment: Accepted by KDD 202
Poly[[diaqua(μ4-1H-benzimidazole-5,6-dicarboxylato)strontium] monohydrate]
Each of the carboxylate –CO2 fragments of the dianion ligand in the title compound, {[Sr(C9H4N2O4)(H2O)2]·H2O}n, chelates to a SrII atom and at the same time, one of the two O atoms coordinates to a third SrII atom. The μ4-bridging mode of the dianion generates a square-grid layer motif; adjacent layers are connected by O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds, forming a three-dimensional network. The eight-coordinate Sr atom exists in a distorted square-antiprismatic geometry. The crystal studied was a non-merohedral twin with a minor twin component of 24%
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