The role of technetium-99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma

BACKGROUND: The authors prospectively evaluated the correlation between technetium-99m methoxyisobutyl isonitrile ( 99m Tc-MIBI) accumulation in tumors and response to induction chemotherapy in patients with nasopharyngeal carcinoma (NPC). METHODS: Eighty-six patients with locally advanced NPC underwent single-photon emission computed tomography 15 minutes after an intravenous injection of 740 megabecquerels (20 mCi) 99m Tc-MIBI before chemotherapy. The tumor uptake ratio (TUR) was calculated. Two weeks after the second cycle of combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (DDP), the tumor response rate was evaluated. The correlation between 99m Tc-MIBI accumulation in tumors and response to chemotherapy with 5-FU/DDP was examined. RESULTS: Positive accumulation of 99m Tc-MIBI in tumors was observed in 76 patients (88.4%). The tumor response was a complete response (CR) in 8 patients, a partial response (PR) in 68 patients, stable disease (SD) in 9 patients, and progressive disease (PD) in 1 patient. The response rate (CR and PR) to 5-FU/DDP chemotherapy in patients who had positive 99m Tc-MIBI accumulation (tumor uptake ratio [TUR] >1.1) was higher than that in patients who had negative 99m Tc-MIBI accumulation (TUR ≤1.1; 98.7% vs 10%; P < .001). CONCLUSIONS: Patients with negative 99m Tc-MIBI accumulation were resistant to 5-FU/DDP chemotherapy. 99m Tc-MIBI imaging in patients with NPC was capable of predicting tumor response to chemotherapy with 5-FU/DDP and can help in the selection of patients for induction chemotherapy. Cancer 2011. © 2010 American Cancer Society.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/84384/1/25802_ftp.pd

消化内科护理风险及管理对策分析

Objective: To explore the common nursing risk in department of gastroenterology and clinical nursing management strategies, in order to provide the basis for nursing in the department of gastroenterology. Methods: Analyze and discuss of the common characteristics of nursing risk in our hospital department of gastroenterology, and summarize the countermeasure and method of correlation of risk management. The implementation of risk management as the observation group and the other as the control group, and clinical nursing effect between the two groups would be compared. Moreover, nursing ability improvement circumstance for the nursing staff was compared before and after the implementation of risk management. Results: The observation group after the risk management of nursing errors, medical disputes and the patients' satisfaction were better than the control group, there is statistical significance (P&lt; 0.05). After the risk management in Department of gastroenterology, nursing work of nursing staff in various digestive operation is proficient, medical record documents writing norms, communication ability, the emergency ability is superior before the implementation of risk management, there is statistical significance (P&lt;0.05). Conclusion: In the nursing management in the Department of gastroenterology, the implementation of risk management is helpful to improve the ability of nursing and the nursing quality, reduce nursing risk in Department of gastroenterology, and improve hospital patient satisfaction.目的  探讨消化内科中常见的护理风险以及临床护理管理对策，为消化内科的安全护理提供依据。方法  对本院消化内科常见的护理风险特点进行分析讨论，总结相关风险管理的对策与方法。将未实施风险管理作为对照组，实施风险管理为观察组，比较两组临床护理效果，并对护理人员实施风险管理前、后护理能力改善情况进行对比研究。结果  观察组实施风险管理后护理差错、医疗纠纷以及患者护理满意度方面均优于对照组，比较差异有显著性（P&lt;0.05），具有统计学意义。实施风险管理后护理人员对消化内科各种护理工作操作熟练程度，病历文书书写规范性，沟通能力，应急能力等方面均优于实施风险管理前，比较差异有显著性（P&lt;0.05），具有统计学意义。结论  在消化内科的护理管理中，实施风险管理有助于提高护理能力和护理质量，降低消化内科的护理风险，提高患者的满意度

The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer

<p>Abstract</p> <p>Background</p> <p>High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo.</p> <p>Methods</p> <p>1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups: the normal control group, the single fraction with 18 Gy group, the two subfractions with 30 min interval group, the seven subfractions with 5 min interval group, the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency, the tumor growth delay and the mice survival time were analyzed.</p> <p>Results</p> <p>The tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy (P < 0.05). The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P < 0.05). There was no significant difference between groups with same delivery time (P > 0.05). Compared to the group with single fraction of 18 Gy, the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min.</p> <p>Conclusions</p> <p>The prolonged delivery time with same radiation dose shorten the tumor growth delay and survival time in the mice implanted with Lewis lung cancer. The anti-tumor effect decreased with elongation of the total interfractional time.</p

A parametric study on the performance characteristics of an evacuated flat-plate photovoltaic/thermal (PV/T) collector

An evacuated flat-plate photovoltaic/thermal (E-PV/T) collector was proposed. The inner space of the E-PV/T collector is vacuumed to suppress non-radiative heat losses, thus increasing thermal efficiency of the collector. Therefore, the E-PV/T collector has the potential to simultaneously deliver electricity and heat at high temperatures. A mathematic model was developed to evaluate the performance of the E-PV/T collector. The effect of some key parameters (e.g., initial water temperature in the water tank, vacuum degree, long-wave panel emissivity, and temperature coefficient of solar cells) on the performance of the E-PV/T system was investigated and the results were compared with a normal flat-plate PV/T (N-PV/T) system. Results suggest that the vacuum helps to enhance the total efficiency by nearly 10 percentage points in high-temperature conditions (>80 °C). The vacuum degree of the upper space exerts a greater effect on system efficiencies compared to that of the lower space. Lower long-wave panel emissivity and greater temperature coefficient of the solar cell promote the performance of the collector. By lowering the long-wave panel emissivity from 0.95 to 0.05, the total efficiency soars from 26.82% to 61.20%. This study may help to guide parametric optimization and operation strategy of flat-plate PV/T collectors for high-temperature applications

PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease

Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are considered to be the most critical targets of MLL fusions and their co-expression rapidly induces AML. MEIS1 and PBX3 are not individually able to transform cells and were therefore hypothesized to function as cofactors of HOXA9. However, in this study we demonstrate that co-expression of PBX3 and MEIS1 (PBX3/MEIS1), without ectopic expression of a HOX gene, is sufficient for transformation of normal mouse hematopoietic stem/progenitor cells in vitro. Moreover, PBX3/MEIS1 overexpression also caused AML in vivo, with a leukemic latency similar to that caused by forced expression of MLL-AF9, the most common form of MLL fusions. Furthermore, gene expression profiling of hematopoietic cells demonstrated that PBX3/MEIS1 overexpression, but not HOXA9/MEIS1, HOXA9/PBX3 or HOXA9 overexpression, recapitulated the MLL-fusion-mediated core transcriptome, particularly upregulation of the endogenous Hoxa genes. Disruption of the binding between MEIS1 and PBX3 diminished PBX3/MEIS1-mediated cell transformation and HOX gene upregulation. Collectively, our studies strongly implicate the PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and suggest that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML. Therefore, targeting the MEIS1/PBX3 interaction may represent a promising therapeutic strategy to treat these AML subtypes