rac-tert-Butyl 2-{5-[(4-{2-[methyl(pyri­din-2-yl)amino]ethoxy}phenyl)methyl]-2,4-dioxo-1,3-thiazolidin-3-yl}acetate

The title compound, C24H29N3O5S, is a chiral mol­ecule which crystallizes in a centrosymmetric space group as a racemate. The thia­zolidine ring forms the dihedral angles of 29.22 (12) and 67.79 (10)° with the benzene and pyridine rings, respectively. The benzene and pyridine rings are tilted by dihedral angle of 67.18 (9)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network

Novel Design and Adaptive Fuzzy Control of a Lower-Limb Elderly Rehabilitation

Design and control of a lower-limb exoskeleton rehabilitation of the elderly are the main challenge for health care in the past decades. In order to satisfy the requirements of the elderly or disabled users, this paper presents a novel design and adaptive fuzzy control of lower-limb empowered rehabilitation, namely MOVING UP. Different from other rehabilitation devices, this article considers active rehabilitation training devices. Firstly, a novel product design method based on user experience is proposed for the lower-limb elderly exoskeleton rehabilitation. At the same time, in order to achieve a stable operation control for the assistant rehabilitation system, an adaptive fuzzy control scheme is discussed. Finally, the feasibility of the design and control method is validated with a detailed simulation study and the human-interaction test. With the booming demand in the global market for the assistive lower-limb exoskeleton, the methodology developed in this paper will bring more research and manufacturing interests

Rethinking Missing Data: Aleatoric Uncertainty-Aware Recommendation

Historical interactions are the default choice for recommender model training, which typically exhibit high sparsity, i.e., most user-item pairs are unobserved missing data. A standard choice is treating the missing data as negative training samples and estimating interaction likelihood between user-item pairs along with the observed interactions. In this way, some potential interactions are inevitably mislabeled during training, which will hurt the model fidelity, hindering the model to recall the mislabeled items, especially the long-tail ones. In this work, we investigate the mislabeling issue from a new perspective of aleatoric uncertainty, which describes the inherent randomness of missing data. The randomness pushes us to go beyond merely the interaction likelihood and embrace aleatoric uncertainty modeling. Towards this end, we propose a new Aleatoric Uncertainty-aware Recommendation (AUR) framework that consists of a new uncertainty estimator along with a normal recommender model. According to the theory of aleatoric uncertainty, we derive a new recommendation objective to learn the estimator. As the chance of mislabeling reflects the potential of a pair, AUR makes recommendations according to the uncertainty, which is demonstrated to improve the recommendation performance of less popular items without sacrificing the overall performance. We instantiate AUR on three representative recommender models: Matrix Factorization (MF), LightGCN, and VAE from mainstream model architectures. Extensive results on two real-world datasets validate the effectiveness of AUR w.r.t. better recommendation results, especially on long-tail items

Mining Unfollow Behavior in Large-Scale Online Social Networks via Spatial-Temporal Interaction

Online Social Networks (OSNs) evolve through two pervasive behaviors: follow and unfollow, which respectively signify relationship creation and relationship dissolution. Researches on social network evolution mainly focus on the follow behavior, while the unfollow behavior has largely been ignored. Mining unfollow behavior is challenging because user's decision on unfollow is not only affected by the simple combination of user's attributes like informativeness and reciprocity, but also affected by the complex interaction among them. Meanwhile, prior datasets seldom contain sufficient records for inferring such complex interaction. To address these issues, we first construct a large-scale real-world Weibo dataset, which records detailed post content and relationship dynamics of 1.8 million Chinese users. Next, we define user's attributes as two categories: spatial attributes (e.g., social role of user) and temporal attributes (e.g., post content of user). Leveraging the constructed dataset, we systematically study how the interaction effects between user's spatial and temporal attributes contribute to the unfollow behavior. Afterwards, we propose a novel unified model with heterogeneous information (UMHI) for unfollow prediction. Specifically, our UMHI model: 1) captures user's spatial attributes through social network structure; 2) infers user's temporal attributes through user-posted content and unfollow history; and 3) models the interaction between spatial and temporal attributes by the nonlinear MLP layers. Comprehensive evaluations on the constructed dataset demonstrate that the proposed UMHI model outperforms baseline methods by 16.44% on average in terms of precision. In addition, factor analyses verify that both spatial attributes and temporal attributes are essential for mining unfollow behavior.Comment: 8 pages, 7 figures, Accepted by AAAI 202

TransRec: Learning Transferable Recommendation from Mixture-of-Modality Feedback

Learning large-scale pre-trained models on broad-ranging data and then transfer to a wide range of target tasks has become the de facto paradigm in many machine learning (ML) communities. Such big models are not only strong performers in practice but also offer a promising way to break out of the task-specific modeling restrictions, thereby enabling task-agnostic and unified ML systems. However, such a popular paradigm is mainly unexplored by the recommender systems (RS) community. A critical issue is that standard recommendation models are primarily built on categorical identity features. That is, the users and the interacted items are represented by their unique IDs, which are generally not shareable across different systems or platforms. To pursue the transferable recommendations, we propose studying pre-trained RS models in a novel scenario where a user's interaction feedback involves a mixture-of-modality (MoM) items, e.g., text and images. We then present TransRec, a very simple modification made on the popular ID-based RS framework. TransRec learns directly from the raw features of the MoM items in an end-to-end training manner and thus enables effective transfer learning under various scenarios without relying on overlapped users or items. We empirically study the transferring ability of TransRec across four different real-world recommendation settings. Besides, we look at its effects by scaling source and target data size. Our results suggest that learning neural recommendation models from MoM feedback provides a promising way to realize universal RS

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex

Human neurons function over an entire lifetime, yet the molecular mechanisms which perform their functions and protecting against neurodegenerative disease during aging are still elusive. Here, we conducted a systematic study on the human brain aging by using the weighted gene correlation network analysis (WGCNA) method to identify meaningful modules or representative biomarkers for human brain aging. Significantly, 19 distinct gene modules were detected based on the dataset GSE53890; among them, six modules related to the feature of brain aging were highly preserved in diverse independent datasets. Interestingly, network feature analysis confirmed that the blue modules demonstrated a remarkably correlation with human brain aging progress. Besides, the top hub genes including PPP3CB, CAMSAP1, ACTR3B, and GNG3 were identified and characterized by high connectivity, module membership, or gene significance in the blue module. Furthermore, these genes were validated in mice of different ages. Mechanically, the potential regulators of blue module were investigated. These findings highlight an important role of the blue module and its affiliated genes in the control of normal brain aging, which may lead to potential therapeutic interventions for brain aging by targeting the hub genes

An efficient synthesis of Vildagliptin intermediates

Efficient and high yielding methods for the preparation of vildagliptin 1 intermediate of (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile 2 and 3-amino-1-adamantane alcohol 3 respectively have been described. (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 2 has been synthesized from l-proline 2a via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot reactions. 3-Amino-1-adamantane alcohol 3 has been prepared from amantadine hydrochloride via oxidation by sulfuric acid/nitric acid and boric acid as catalyst, and has been subjected to ethanol extraction. The overall yield is about 95%.