Evaluating structural and performance dynamics of a differentiated U.S. apple industry

2012 Summer.Includes bibliographical references.There is a growing public interest, and consequently, support for public policies and programs to support local food systems. These programs aim to inform consumers about the potential benefits of local foods and influence consumers' choice among differentiable foods. As state promotion and marketing programs have been widely adopted throughout the country, demand for local produce and market opportunities for locally-branded products have increased significantly. Local promotion programs have also started to influence the structure of markets, as demand has stimulated a proliferation of localized, direct marketing supply chains linking growers directly to consumers. However, there are few true examinations focused on the welfare implications surrounding the restructuring of food markets and or the underlying economic performance of market innovations. The main objective of this study is to explore the structural and performance dynamics of a market as a result of new labeling efforts and promotional campaigns, highlighting the availability of locally grown products (both in direct markets and within more conventional marketing channels). This study develops a partial equilibrium displacement model for Colorado apples to analyze the impacts of local labeling. The information obtained from the result of this model informs how consumer perceptions and marketing channel structure influence market performance. To complement the broader analysis, the market structure and price relationship at different market levels are examined. The results showed that the Southwest and Northeast retail markets dominated national retail markets and the Northwest retail market dominated western retail markets in terms of its influence on retail prices. Not surprisingly the Yakima Valley and Wenatchee District in Washington significantly affected the price formation process of all other shipping points. If the unknown transaction cost band is allowed to vary according to transportation costs and seasonality, it may more closely mimic suppliers who view more opportunities to adjust their supply between regional markets in search of potential profits. Overall, local labeling increases consumers' willingness to pay for local apples relative to domestic apples in Colorado, and subsequently, demand will shift toward local apples and the supply will shift toward direct markets in Colorado. In terms of producer surplus, Colorado suppliers for direct markets gain while Colorado suppliers for shipping points lose in short run. In the long run, both suppliers will gain but the suppliers for direct markets will gain more than the suppliers for shipping points. Overall, the Colorado producers lose in the short run while they gain in the long run

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.

Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer. In contrast, amplification of DYRK2 gene occurs in esophageal/lung adenocarcinoma, implying the role of DYRK2 as a potential oncogene. However, its clinical role in colorectal cancer (CRC) has not been explored. In this study, we analyzed the expression of DYRK2 from Oncomine database and found that DYRK2 level is lower in primary or metastatic CRC compared to adjacent normal colon tissue or non-metastatic CRC, respectively, in 6 colorectal carcinoma data sets. The correlation between DYRK2 expression and clinical outcome in 181 CRC patients was also investigated by real-time PCR and IHC. DYRK2 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Functional studies confirmed that DYRK2 inhibited cell invasion and migration in both HCT116 and SW480 cells and functioned as a tumor suppressor in CRC cells. Furthermore, the lower DYRK2 levels were correlated with tumor sites (P = 0.023), advanced clinical stages (P = 0.006) and shorter survival in the advanced clinical stages. Univariate and multivariate analyses indicated that DYRK2 expression was an independent prognostic factor (P < 0.001). Taking all, we concluded that DYRK2 a novel prognostic biomarker of human colorectal cancer

What Are the Economic Welfare Effects of Local Food Marketing? Exploring Impacts with the Case of Colorado Apples

This paper explores the welfare changes as a result of changes in prices and quantities of Colorado labeled apples relative to domestically produced apples, using equilibrium displacement model with two-regions: Colorado State and the rest of the United States. The results showed that in the short run producers would lose $300, while in the long run producers would increase supply to capture$263,000 in increased surplus.local food marketing, marketing channel, market segmentation, equilibrium displacement model, Agribusiness, Agricultural and Food Policy, Community/Rural/Urban Development, Consumer/Household Economics, Demand and Price Analysis, Food Consumption/Nutrition/Food Safety, Food Security and Poverty, Industrial Organization, Institutional and Behavioral Economics, Marketing,

Scaffold-based lung tumor culture on porous PLGA microparticle substrates

Scaffold-based cancer cell culture techniques have been gaining prominence especially in the last two decades. These techniques can potentially overcome some of the limitations of current three-dimensional cell culture methods, such as uneven cell distribution, inadequate nutrient diffusion, and uncontrollable size of cell aggregates. Porous scaffolds can provide a convenient support for cell attachment, proliferation and migration, and also allows diffusion of oxygen, nutrients and waste. In this paper, a comparative study was done on porous poly (lactic-co-glycolic acid) (PLGA) microparticles prepared using three porogens—gelatin, sodium bicarbonate (SBC) or novel poly N-isopropylacrylamide [PNIPAAm] particles, as substrates for lung cancer cell culture. These fibronectin-coated, stable particles (19–42 μm) supported A549 cell attachment at an optimal cell seeding density of 250,000 cells/ mg of particles. PLGA-SBC porous particles had comparatively larger, more interconnected pores, and favored greater cell proliferation up to 9 days than their counterparts. This indicates that pore diameters and interconnectivity have direct implications on scaffold-based cell culture compared to substrates with minimally interconnected pores (PLGA-gelatin) or pores of uniform sizes (PLGA-PMPs). Therefore, PLGA-SBC-based tumor models were chosen for preliminary drug screening studies. The greater drug resistance observed in the lung cancer cells grown on porous particles compared to conventional cell monolayers agrees with previous literature, and indicates that the PLGA-SBC porous microparticle substrates are promising for in vitro tumor or tissue development

Correlational Analysis of Sarcopenia and Multimorbidity Among Older Inpatients

BACKGROUND: Sarcopenia and multimorbidity are common in older adults, and most of the available clinical studies have focused on the relationship between specialist disorders and sarcopenia, whereas fewer studies have been conducted on the relationship between sarcopenia and multimorbidity. We therefore wished to explore the relationship between the two. METHODS: The study subjects were older patients (aged ≥ 65 years) who were hospitalized at the Department of Geriatrics of the First Affiliated Hospital of Chongqing Medical University between March 2016 and September 2021. Their medical records were collected. Based on the diagnostic criteria of the Asian Sarcopenia Working Group in 2019, the relationship between sarcopenia and multimorbidity was elucidated. RESULTS: 1.A total of 651 older patients aged 65 years and above with 2 or more chronic diseases were investigated in this study, 46.4% were suffering from sarcopenia. 2. Analysis of the relationship between the number of chronic diseases and sarcopenia yielded that the risk of sarcopenia with 4-5 chronic diseases was 1.80 times higher than the risk of 2-3 chronic diseases (OR 1.80, 95%CI 0.29-2.50), and the risk of sarcopenia with ≥ 6 chronic diseases was 5.11 times higher than the risk of 2-3 chronic diseases (OR 5.11, 95% CI 2.97-9.08), which remained statistically significant, after adjusting for relevant factors. 3. The Charlson comorbidity index was associated with skeletal muscle mass index, handgrip strength, and 6-meter walking speed, with scores reaching 5 and above suggesting the possibility of sarcopenia. 4. After adjusting for some covariates among 14 common chronic diseases in older adults, diabetes (OR 3.20, 95% CI 2.01-5.09), cerebrovascular diseases (OR 2.07, 95% CI 1.33-3.22), bone and joint diseases (OR 2.04, 95% CI 1.32-3.14), and malignant tumors (OR 2.65, 95% CI 1.17-6.55) were among those that still a risk factor for the development of sarcopenia. CONCLUSION: In the hospitalized older adults, the more chronic diseases they have, the higher the prevalence of sarcopenia. When the CCI is 5, attention needs to be paid to the occurrence of sarcopenia in hospitalized older adults