513 research outputs found
A Hyperquenching-calorimetric Method to Determine the Activation Energy of Slow β Relaxation in Metallic Glasses
Dynamics of 2D pancake vortices in layered superconductors
The dynamics of 2D pancake vortices in Josephson-coupled
superconducting/normal - metal multilayers is considered within the
time-dependent Ginzburg-Landau theory. For temperatures close to a
viscous drag force acting on a moving 2D vortex is shown to depend strongly on
the conductivity of normal metal layers. For a tilted vortex line consisting of
2D vortices the equation of viscous motion in the presence of a transport
current parallel to the layers is obtained. The specific structure of the
vortex line core leads to a new dynamic behavior and to substantial deviations
from the Bardeen-Stephen theory. The viscosity coefficient is found to depend
essentially on the angle between the magnetic field and the
axis normal to the layers. For field orientations close to the layers
the nonlinear effects in the vortex motion appear even for slowly moving vortex
lines (when the in-plane transport current is much smaller than the
Ginzburg-Landau critical current). In this nonlinear regime the viscosity
coefficient depends logarithmically on the vortex velocity .Comment: 15 pages, revtex, no figure
Microscopic origin of the fragile-to-strong transition in glass-forming liquids:- An Invited Talk
Integrated analysis of RNA and DNA from the phase III trial CALGB 40601 identifies predictors of response to trastuzumab-based neoadjuvant chemotherapy in HER2-positive breast cancer
Purpose: Response to a complex trastuzumab-based regimen is affected by multiple features of the tumor and its microenvironment. Developing a predictive algorithm is key to optimizing HER2-targeting therapy. Experimental Design: We analyzed 137 pretreatment tumors with mRNA-seq and DNA exome sequencing from CALGB 40601, a neoadjuvant phase III trial of paclitaxel plus trastuzumab with or without lapatinib in stage II to III HER2-positive breast cancer. We adopted an Elastic Net regularized regression approach that controls for covarying features within high-dimensional data. First, we applied 517 known gene expression signatures to develop an Elastic Net model to predict pCR, which we validated on 143 samples from four independent trials. Next, we performed integrative analyses incorporating clinicopathologic information with somatic mutation status, DNA copy number alterations (CNA), and gene signatures. Results: The Elastic Net model using only gene signatures predicted pCR in the validation sets (AUC ¼ 0.76). Integrative analyses showed that models containing gene signatures, clinical features, and DNA information were better pCR predictors than models containing a single data type. Frequently selected variables from the multiplatform models included amplifications of chromosome 6p, TP53 mutation, HER2-enriched subtype, and immune signatures. Variables predicting resistance included Luminal/ERþ features. Conclusions: Models using RNA only, as well as integrated RNA and DNA models, can predict pCR with improved accuracy over clinical variables. Somatic DNA alterations (mutation, CNAs), tumor molecular subtype (HER2E, Luminal), and the microenvironment (immune cells) were independent predictors of response to trastuzumab and paclitaxel-based regimens. This highlights the complexity of predicting response in HER2-positive breast cancer
Gain in a quantum wire laser of high uniformity
A multi-quantum wire laser operating in the 1-D ground state has been
achieved in a very high uniformity structure that shows free exciton emission
with unprecedented narrow width and low lasing threshold. Under optical pumping
the spontaneous emission evolves from a sharp free exciton peak to a
red-shifted broad band. The lasing photon energy occurs about 5 meV below the
free exciton. The observed shift excludes free excitons in lasing and our
results show that Coulomb interactions in the 1-D electron-hole system shift
the spontaneous emission and play significant roles in laser gain.Comment: 4 pages, 4 figures, prepared by RevTe
Statefinder and Om Diagnostics for Interacting New Holographic Dark Energy Model and Generalized Second Law of Thermodynamics
In this work, we have considered that the flat FRW universe is filled with
the mixture of dark matter and the new holographic dark energy. If there is an
interaction, we have investigated the natures of deceleration parameter,
statefinder and diagnostics. We have examined the validity of the first
and generalized second laws of thermodynamics under these interactions on the
event as well as apparent horizon. It has been observed that the first law is
violated on the event horizon. However, the generalized second law is valid
throughout the evolution of the universe enveloped by the apparent horizon.
When the event horizon is considered as the enveloping horizon, the generalized
second law is found to break down excepting at late stage of the universe.Comment: 9 pages, 13 figure
Cosmic Microwave Background Anisotropies from Scaling Seeds: Global Defect Models
We investigate the global texture model of structure formation in cosmogonies
with non-zero cosmological constant for different values of the Hubble
parameter. We find that the absence of significant acoustic peaks and little
power on large scales are robust predictions of these models. However, from a
careful comparison with data we conclude that at present we cannot safely
reject the model on the grounds of present CMB data. Exclusion by means of
galaxy correlation data requires assumptions on biasing and statistics. New,
very stringent constraints come from peculiar velocities.
Investigating the large-N limit, we argue that our main conclusions apply to
all global O(N) models of structure formation.Comment: LaTeX file with RevTex, 27 pages, 23 eps figs., submitted to Phys.
Rev. D. A version with higher quality images can be found at
http://mykonos.unige.ch/~kunz/download/lam.tar.gz for the LaTeX archive and
at http://mykonos.unige.ch/~kunz/download/lam.ps.gz for the compiled
PostScript fil
Phantom Divide Crossing with General Non-minimal Kinetic Coupling
We propose a model of dark energy consists of a single scalar field with a
general non-minimal kinetic couplings to itself and to the curvature. We study
the cosmological dynamics of the equation of state in this setup. The coupling
terms have the form and
where
and are coupling parameters and their dimensions depend on the type
of function . We obtain the conditions required for phantom divide
crossing and show numerically that a cosmological model with general
non-minimal derivative coupling to the scalar and Ricci curvatures can realize
such a crossing.Comment: 12 pages, 4 figures. Accepted for publication in Gen. Rel. Grav.
arXiv admin note: substantial text overlap with arXiv:1105.4967,
arXiv:1201.1627, and with arXiv:astro-ph/0610092 by other author
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