Four lanthanide-carboxylate coordination polymers with mixed 2,3-naphthalenedicarboxylate and phen ligands: syntheses, structures, luminescent and magnetic properties

Four new lanthanide-carboxylate coordination polymers of the formula [Ln3L4(phen)4(H2O)4](ClO4)·2H2O, (Ln = Dy (1), Tb (2), Ho (3) and Er (4), L = 2,3-naphthalenedicarboxylate and phen = 1,10-phenanthroline) were solvothermally synthesized. Their structures as well as magnetic and photoluminescent properties were completely investigated. Complexes 1-4 are isostructural and exhibit 1D ribbon-like chains with envelope-like sixteen-membered rings. The DyIII and TbIII complexes show the corresponding characteristic luminescence in the visible region and the ErIII complex shows luminescence in the near-infrared region upon excitation with UV rays. Studies on the magnetic properties are reported. The Dy(III) analog complex 1 exhibits slow magnetic relaxation and could be a new example of a Dy(III) SMM (single molecule magnet)

N-(2-Amino-4,6-dihydroxypyrimidin-5-yl)acetamide dihydrate

The title compound, C6H8N4O3·2H2O, which crystallized as a dihydrate, has two almost planar segments viz. the pyrimidine ring and the C—N—C(=O)—C group [maxmum deviations of 0.020 (2) and 0.014 (2) Å, respectively], with a dihedral angle of 87.45°. In the crystal, the components are linked by O—H⋯O and N—H⋯O hydrogen bonds

Growth of solutions of linear differential equations with meromorphic coefficients of [p,q]-order

In this paper, we investigate the growth of meromorphic solutions to a complex higher order linear differential equation whose coefficients are meromorphic functions of $[p,q]$-orders. We get the results about the lower $[p,q]$-order of solutions of the equation. Moreover, we investigate the $[p,q]$-convergence exponent and the lower $[p,q]$-convergence exponent of distinct zeros of $f(z)-varphi(z).

Kinetic Modeling for Microwave-Enhanced Degradation of Methylene Blue Using Manganese Oxide

This study was originally performed to compare the MnO2-based degradation of aqueous methylene blue (MB) under microwave irradiation- (MW-) enhanced and conventional heating- (CH-) enhanced conditions. The degradation process and kinetics were investigated to elucidate the microwave effect on the reaction. The results showed that all three tested conditions, sole MnO2, MnO2/CH, and MnO2/MW, followed the third-order (second upon MB and first upon MnO2) kinetic model. However, a higher degradation rate of MB was available under the MW-enhanced process, which implies that the “athermal effect” of MW might be of more benefit for the generation of electrophilic oxygen ions (, , and ) to degrade MB. The results showed that the degradation percentage of MB could reach 100%, corresponding to 92% total organic carbon (TOC) removal under microwave irradiation at pH 7.20 for 10 min

Process development of chromatography-based purification on pandemic influenza virus-like particle based vaccines

Since 2013, the H7N9 avian influenza virus is considered a threat to global public health. The development of the H7N9 avian influenza vaccine is one of the most effective strategies to prevent influenza pandemics. Virus-like particles (VLPs) influenza vaccines is non-infectious viral structural proteins. Not only to retain the ability to produce neutralizing antibodies against to viral surface protein, but also safer than the conventional inactivated vaccines. In our previous study, we successfully expressed three structural proteins, hemagglutinin (HA), neuraminidase (NA) and matrix (M1) from influenza A / Taiwan / 1/2013 (H7N9) of the VLP in insect cells. In this study, we present a downstream purification method for the VLP platform. The purification process involves microfiltration, chromatography (using ion exchange, affinity and gel filtration combinations), concentration, diafiltration and sterile filtration steps. In this study, 600 ml of the harvest from the baculovirus expression system was used. The characteristics of VLP volume were examined by HA assay, SDS-PAGE and negative staining transmission electron microscopy (TEM). The overall recovery of HA protein was approximately 38%. In the evaluation of immunized mouse, such virus particles have been shown the HI titer \u3e256. This study demonstrated the chromatographic-based purification process can provide an effective VLP vaccine production for the preparation of the H7N9 influenza pandemic

A role of corazonin receptor in larval-pupal transition and pupariation in the oriental fruit fly Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)

Corazonin (Crz) is a neuropeptide hormone, but also a neuropeptide modulator that is internally released within the CNS, and it has a widespread distribution in insects with diverse physiological functions. Here, we identified and cloned the cDNAs of Bactrocera dorsalis that encode Crz and its receptor CrzR. Mature BdCrz has 11 residues with a unique Ser11 substitution (instead of the typical Asn) and a His in the evolutionary variable position 7. The BdCrzR cDNA encodes a putative protein of 608 amino acids with 7 putative transmembrane domains, typical for the structure of G-protein-coupled receptors. When expressed in Chinese hamster ovary (CHO) cells, the BdCrzR exhibited a high sensitivity and selectivity for Crz (EC50 approximate to 52.5 nM). With qPCR, the developmental stage and tissue-specific expression profiles in B. dorsalis demonstrated that both BdCrz and BdCrzR were highly expressed in the larval stage, and BdCrzR peaked in 2-day-old 3rd-instar larvae, suggesting that the BdCrzR may play an important role in the larval-pupal transition behavior. Immunochemical localization confirmed the production of Crz in the central nervous system (CNS), specifically by a group of three neurons in the dorso-lateral protocerebrum and eight pairs of lateral neurons in the ventral nerve cord. qPCR analysis located the BdCrzR in both the CNS and epitracheal gland, containing the Inka cells. Importantly, dsRNA-BdCrzR-mediated gene-silencing caused a delay in larval-pupal transition and pupariation, and this phenomenon agreed with a delayed expression of tyrosine hydroxylase and dopa-decarboxylase genes. We speculate that CrzR-silencing blocked dopamine synthesis, resulting in the inhibition of pupariation and cuticular melanization. Finally, injection of Crz in head-ligated larvae could rescue the effects. These findings provide a new insight into the roles of Crz signaling pathway components in B. dorsalis and support an important role of CrzR in larval-pupal transition and pupariation behavior