キャリブレーション支援機能を有する使いやすいweb-based XAJモデルの開発と応用

国立大学法人長岡技術科学大

Myanmar traditional medicine formulations and their antioxidant, antiglycation and alpha-glucosidase inhibitory activities: Potentials for antidiabetes complications

Myanmar Traditional Medicine (MTM) has been used since ancient times to treat life-threatening diseases like diabetes. In this study, various in vitro assays were used to prove that four MTM formulations were effective at treating diabetes. Antioxidant activities were determined using in vitro DPPH, nitric oxide (NO), and superoxide (SO) radical scavenging assays. The Folin-Ciocalteu method was used to quantify the total phenolic content, while the BSA-fluorescent antiglycation and α-glucosidase inhibitory assays were utilized to determine the antidiabetic activity of MTMs. Among the tested samples, MTM3 showed the best activities for almost all the biological assays tested in this experiment with the % inhibition of 82.89 ± 1.64 for NO and 65.02 ± 2.82 for SO radical scavenging activity, 92.12 ± 1.18 for α-glucosidase inhibitory activity and IC50 of 180.29 ± 1.6 µg/ml for the antiglycation activity. It also possessed the highest total phenolic content of 149.41 ± 3.7 mg GAE/g of extract/l among the tested samples. Therefore, the findings suggested that MTM could help diabetic patients improve their quality of life through antioxidant activity against several free radicals and their antiglycation and α-glucosidase inhibitory characteristics

A Study of Burkholderia pseudomallei in the Environment of Farms in Thanlyin and Hmawbi Townships, Myanmar.

Melioidosis is a tropical infection, first described in Myanmar but now rarely diagnosed there, which is widespread in Southeast Asia. The infection is predominantly acquired by people and animals through contact with soil or water. This study aimed to detect the causative organism, Burkholderia pseudomallei, in environmental samples from farms in Thanlyin and Hmawbi townships near Yangon, Myanmar. One hundred and twenty soil samples and 12 water samples were collected and processed using standard microbiological methods. Burkholderia species were isolated from 50 of the 120 (42%) soil samples but none of the water samples. Arabinose assimilation was tested to differentiate between B. pseudomallei and the nonpathogenic Burkholderia thailandensis, and seven of 50 isolates (14%) were negative. These were all confirmed as B. pseudomallei by a species-specific multiplex polymerase chain reaction (PCR). This is the first study to detect environmental B. pseudomallei in Myanmar and confirms that melioidosis is still endemic in the Yangon area

The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic précis

<p>Abstract</p> <p>Background</p> <p>The final article in a series of three publications examining the global distribution of 41 dominant vector species (DVS) of malaria is presented here. The first publication examined the DVS from the Americas, with the second covering those species present in Africa, Europe and the Middle East. Here we discuss the 19 DVS of the Asian-Pacific region. This region experiences a high diversity of vector species, many occurring sympatrically, which, combined with the occurrence of a high number of species complexes and suspected species complexes, and behavioural plasticity of many of these major vectors, adds a level of entomological complexity not comparable elsewhere globally. To try and untangle the intricacy of the vectors of this region and to increase the effectiveness of vector control interventions, an understanding of the contemporary distribution of each species, combined with a synthesis of the current knowledge of their behaviour and ecology is needed.</p> <p>Results</p> <p>Expert opinion (EO) range maps, created with the most up-to-date expert knowledge of each DVS distribution, were combined with a contemporary database of occurrence data and a suite of open access, environmental and climatic variables. Using the Boosted Regression Tree (BRT) modelling method, distribution maps of each DVS were produced. The occurrence data were abstracted from the formal, published literature, plus other relevant sources, resulting in the collation of DVS occurrence at 10116 locations across 31 countries, of which 8853 were successfully geo-referenced and 7430 were resolved to spatial areas that could be included in the BRT model. A detailed summary of the information on the bionomics of each species and species complex is also presented.</p> <p>Conclusions</p> <p>This article concludes a project aimed to establish the contemporary global distribution of the DVS of malaria. The three articles produced are intended as a detailed reference for scientists continuing research into the aspects of taxonomy, biology and ecology relevant to species-specific vector control. This research is particularly relevant to help unravel the complicated taxonomic status, ecology and epidemiology of the vectors of the Asia-Pacific region. All the occurrence data, predictive maps and EO-shape files generated during the production of these publications will be made available in the public domain. We hope that this will encourage data sharing to improve future iterations of the distribution maps.</p

Determinations of Nutritional Compositions and Antioxidant Activity in the Leaves of Morinda citrifolia Linn

The leaves of Morinda citrifolia Linn. collected from Mandalay University Campus, Mahaaungmyay Township, Mandalay Region were selected for reliminary phytochemical screening, elemental analysis, determinations of nutritional compositions and antioxidant activity. The phytochemical compositions of the sample was investigated using test tube method. The mineral elements present in the sample were determined using Energy Dispersive X-ray Fluorescence (EDXRF spectrometer. The presence of proteins in the sample was investigated by qualitative tests. The nutritional values of the sample were also determined. The antioxidant activity of the sample was tested by DPPH (1,1 diphenyl-2-picryl-hydrazyl) assay using ascorbic acid as standard

STUDY ON COAGULATION AND FIBRINOLYTIC SYSTEMS IN PRE-ECLAMPSIA AND THE SHORT TERM EFFECTS OF METHYLDOPA AND ISRADIPINE ON HAEMOSTATIC MECHANISMS IN PRE-ECLAMPSIA

Master'sMASTER OF SCIENC

Ibrutinib-induced cardiomyopathy

The use of ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) and other hematologic malignancies is blooming. Atrial fibrillation is a known side effect of ibrutinib but cardiomyopathy was not reported previously. We present an 88-year-old man with CLL who was admitted to the hospital with new-onset atrial fibrillation and symptomatic systolic congestive heart failure one month after ibrutinib initiation. Although ibrutinib was discontinued, the patient continues to have a low ejection fraction four months after discontinuation. Ischemic heart disease was ruled out with normal cardiac catheterization. This case highlights a possible new side effect of ibrutinib that needs to be monitored while patients receive this medication

Statistical Model of Length Based Methods in Developing English-Myanmar Parallel Corpus

The paper is about developing an aligned English-Myanmar parallel corpus. This paper will describe method for aligning sentences based on simple statistical model of length. Parallel corpus is pairs of translation alignment of the bitext. We have used Gale &amp; Church method to get translation alignments. Parallel corpus helps in making statistical bilingual dictionary, in supporting statistical machine translation and in supporting in training data for word sense disambiguation. The program is implemented in Java language

Pancreatic Adenocarcinoma Masquerading as Idiopathic Chronic Pancreatitis with Delayed Diagnosis

Pancreatic cancer carries poor prognosis. Establishing the diagnosis early could help in improving outcome. We are presenting a case of pancreatic cancer with delayed diagnosis. Our 60-year-old patient underwent multiple endoscopic ultrasound-guided biopsies with no evidence of malignancy. He had normal molecular tumor biomarkers. The patient needed 8 months to receive the diagnosis and initiate the treatment. There are no specific guidelines regarding choice of tissue sampling modalities in such cases