2,616 research outputs found
Seebeck Coefficients in Nanoscale Junctions: Effects of Electron-vibration Scattering and Local Heating
We report first-principles calculations of inelastic Seebeck coefficients in
an aluminum monatomic junction. We compare the elastic and inelastic Seebeck
coefficients with and without local heating. In the low temperature regime, the
signature of normal modes in the profiles of the inelastic Seebeck effects is
salient. The inelastic Seebeck effects are enhanced by the normal modes, and
further magnified by local heating. In the high temperature regime, the
inelastic Seebeck effects are weakly suppressed due to the quasi-ballistic
transport.Comment: 3 Figure
Evaluation of innovative sprayed-concrete-lined tunnelling
The front-shunt tunnel was the first tunnel of the Terminal 5 project at Heathrow to be constructed, and was the first section of sprayed-concrete-lined (SCL) tunnel to be constructed using the method known as LaserShell. This innovation represented a significant deviation from the methods previously used in SCL construction. Therefore it was subjected to a careful examination before and during construction using sophisticated 3D numerical modelling and monitoring during construction. The paper presents typical results from surface settlement levelling, inclinometers and extensometers, pressure cells and tunnel lining displacement measurements, and comments on the performance of the methods and instruments used. The paper then presents the methodology and typical results of the numerical modelling, and shows that the predictions of displacements and stresses compared well with the field measurements. In terms of the control of ground deformations and structural safety the tunnel performed well
New Confidence Intervals for the Difference between Two Sensitivities at a Fixed Level of Specificity
For two continuous-scale diagnostic tests, it is of interest to compare their sensitivities at a predetermined level of specificity. In this paper we propose three new intervals for the difference between two sensitivities at a fixed level of specificity. These intervals are easy to compute. We also conduct simulation studies to compare the relative performance of the new intervals with the existing normal approximation based interval proposed by Wieand et al (1989). Our simulation results show that the newly proposed intervals perform better than the existing normal approximation based interval in terms of coverage accuracy and interval length
Criterion of Incipient Re-Suspension of Deposition by Density Currents
Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv
Constructing an Index for Brand Equity: A Hospital Example
If two hospitals are providing identical services in all respects, except for the brand name, why are customers willing to pay more for one hospital than the other? That is, the brand name is not just a name, but a name that contains value (brand equity). Brand equity is the value that the brand name endows to the product, such that consumers are willing to pay a premium price for products with the particular brand name. Accordingly, a company needs to manage its brand carefully so that its brand equity does not depreciate. Although measuring brand equity is important, managers have no brand equity index that is psychometrically robust and parsimonious enough for practice. Indeed, index construction is quite different from conventional scale development. Moreover, researchers might still be unaware of the potential appropriateness of formative indicators for operationalizing particular constructs. Towards this end, drawing on the brand equity literature and following the index construction procedure, this study creates a brand equity index for a hospital. The results reveal a parsimonious five-indicator brand equity index that can adequately capture the full domain of brand equity. This study also illustrates the differences between index construction and scale development
The Role of Formal and Social Control in Information Security Behaviors
The purpose of this study is to explore the effect of formal and social control on in-role and extra-role security behaviors. Following past studies, we reexamine the effect of formal control on behaviors. Based on social control theory, we further hypothesize the effect of social control on security behaviors. Data collected from 259 members of IS departments confirmed our hypotheses that both formal control and social control generate effects on both in-role and extrarole security behaviors. Implications for academia and practitioners are also provided
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FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.
BackgroundThe transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2 has been considered as a key pharmacological target. Unfortunately, there are no specific Nrf2 inhibitors for therapeutic application. Moreover, high Nrf2 activity in many tumors without Keap1 or Nrf2 mutations suggests that alternative mechanisms of Nrf2 regulation exist.MethodsInteraction of FAM129B with Keap1 is demonstrated by immunofluorescence, colocalization, co-immunoprecipitation and mammalian two-hybrid assay. Antioxidative function of FAM129B is analyzed by measuring ROS levels with DCF/flow cytometry, Nrf2 activation using luciferase reporter assay and determination of downstream gene expression by qPCR and wester blotting. Impact of FAM129B on in vivo chemosensitivity is examined in mice bearing breast and colon cancer xenografts. The clinical relevance of FAM129B is assessed by qPCR in breast cancer samples and data mining of publicly available databases.FindingsWe have demonstrated that FAM129B in cancer promotes Nrf2 activity by reducing its ubiquitination through competition with Nrf2 for Keap1 binding via its DLG and ETGE motifs. In addition, FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative signaling and confers poor prognosis in breast and lung cancer.InterpretationThese findings demonstrate the important role of FAM129B in Nrf2 activation and antioxidative response, and identify FMA129B as a potential therapeutic target. FUND: The Chang Gung Medical Foundation (Taiwan) and the Ministry of Science and Technology (Taiwan)
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