A three-dimensional finite element modelling of human chest injury following front or side impact loading

Based on anatomical features of a 50th percentile adult male, three-dimensional (3D) finite element (FE) models of ribs, sternum, vertebrae, intervertebral discs, clavicle, scapula, pelvis, skin, head, muscles and limbs were developed in this study. After integrating/assembling various organs and tissues, a bio-mechanical FE model of the human body with adult male characteristics was produced. Furthermore, a chest frontal and lateral collision theory model was built and was validated by using previously published data from corpse frontal and lateral chest impact collision experiments. Good agreements were found between the simulation results of our model and the experimental data as well as theoretical calculations in the contact force, sternum displacement, and force-displacement response. These data suggest that this 3D FE model is effective and has good bio-fidelity in assessing chest biomechanical responses and thoracic injuries upon impact loading. Therefore this model can potentially be useful for evaluating thoracic injuries in car crashes and assessing chest rib fractures and internal organ/tissue damages

A three-dimensional finite element modelling of human chest injury following front or side impact loading

Based on anatomical features of a 50th percentile adult male, three-dimensional (3D) finite element (FE) models of ribs, sternum, vertebrae, intervertebral discs, clavicle, scapula, pelvis, skin, head, muscles and limbs were developed in this study. After integrating/assembling various organs and tissues, a bio-mechanical FE model of the human body with adult male characteristics was produced. Furthermore, a chest frontal and lateral collision theory model was built and was validated by using previously published data from corpse frontal and lateral chest impact collision experiments. Good agreements were found between the simulation results of our model and the experimental data as well as theoretical calculations in the contact force, sternum displacement, and force-displacement response. These data suggest that this 3D FE model is effective and has good bio-fidelity in assessing chest biomechanical responses and thoracic injuries upon impact loading. Therefore this model can potentially be useful for evaluating thoracic injuries in car crashes and assessing chest rib fractures and internal organ/tissue damages

A three-dimensional finite element modelling of human chest injury following front or side impact loading

Based on anatomical features of a 50th percentile adult male, three-dimensional (3D) finite element (FE) models of ribs, sternum, vertebrae, intervertebral discs, clavicle, scapula, pelvis, skin, head, muscles and limbs were developed in this study. After integrating/assembling various organs and tissues, a bio-mechanical FE model of the human body with adult male characteristics was produced. Furthermore, a chest frontal and lateral collision theory model was built and was validated by using previously published data from corpse frontal and lateral chest impact collision experiments. Good agreements were found between the simulation results of our model and the experimental data as well as theoretical calculations in the contact force, sternum displacement, and force-displacement response. These data suggest that this 3D FE model is effective and has good bio-fidelity in assessing chest biomechanical responses and thoracic injuries upon impact loading. Therefore this model can potentially be useful for evaluating thoracic injuries in car crashes and assessing chest rib fractures and internal organ/tissue damages

Molecular photo-thermal optical coherence phase microscopy using gold nanorods

Optical coherence tomography (OCT) is a non-invasive interferometry imaging technique with micrometre scale resolution at millimetre scale penetration depths in highly scattering tissues. This study describes a new evolution of OCT, termed molecular optical coherence phase microscopy (molecular OCPM), which is capable of imaging the expression of molecular markers at the cellular level using gold nanorods as photothermal imaging agents. Gold nanorods were selected as the imaging agents due to their excellent photothermal energy conversion efficiency and tuneable plasmon bands. The gold nanorods were surface functionalized to achieve efficient and specific targeting of the tyrosine kinase human epidermal growth factor receptor HER2 molecular markers used as a model tumor biomarker. Phase modulation retrieval was used to generate photothermal maps which were overlayed on intensity images. Phase modulation within the filter corresponding to the laser excitation modulation frequency was clearly observed for cells targeted with the molecular photothermal imaging agents. These results confirm the ability of photothermal optical coherence phase microscopy to image accurately at the cellular level gold nanorods molecularly targeted to a biomarker expressed on cancer cell membranes, paving the way for its application to novel bioimaging procedures