Competitive Landscape of Asian Cruise Ports

The cruise industry has experienced a stable growth with an average of 7.2 % annual growth rate of passenger numbers since 1990 (Cruise Lines International Association [CLIA], 2010). The popularity of cruise vacation among the public can also be reflected in the full occupancy of cruise lines and the continuous increase of supply (CLIA, 2013a). Data from the 26 member cruise lines of CLIA indicated that 13 more ships were introduced in 2012, with 17,774 new beds (CLIA, 2013b). Despite the increased revenue of cruise tourism, only a very small percentage of people in the world have cruised. Taking the U.S. for an example, only 3 % of Americans traveled with cruise in 2011 even with the country’s dominant role in the global cruising arena. Therefore, there is ample room for further development of cruise tourism in the global market. Although the development of cruise tourism is not a recent phenomenon, the focus of development has been on North America followed by Europe. In 2012, as much as 68 % of cruise passengers were sourced from North America (CLIA, 2013c). The European cruise source markets also maintained a double-digit annual growth rate between 2007 and 2011 (European Cruise Council, 2013). While remaining active in North America and Europe, the cruise industry has started to explore new markets in Asia in recent years. The rising role of Asia in the global economy has drawn much attention to the Asi

Resident Sentiment: Preliminary Conceptualization and Measurement

Understanding how residents view and react to tourism development is an important topic in tourism literature. To date, most studies focused on the formation and change of locals’ attitudes, whose predictive power to behaviors remains controversial. This study proposes “resident sentiment” as a more encompassing concept to describe local residents’ overall views of tourism development, with attitude as a constituent part. Further, the research team suggests two levels of sentiment: individual sentiment being an internal disposition shaped mainly by private encounters, and public sentiment being shared feelings and reactions resulted from dynamic, multilateral interactions among people. Guided by social exchange and social representations theories, personal experience, social interactions, and destination characteristics are proposed as potential sources of individual sentiment, and mass and social media as a proxy of a community’s public sentiment. A model is proposed to illustrate the determinants and consequences of resident sentiment and interrelationships among key variables

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits

D-amino acid oxidase (DAO) has been reported to be associated with schizophrenia. This study aimed to search for genetic variants associated with this gene. The genomic regions of all exons, highly conserved regions of introns, and promoters of this gene were sequenced. Potentially meaningful single-nucleotide polymorphisms (SNPs) obtained from direct sequencing were selected for genotyping in 600 controls and 912 patients with schizophrenia and in a replicated sample consisting of 388 patients with schizophrenia. Genetic associations were examined using single-locus and haplotype association analyses. In single-locus analyses, the frequency of the C allele of a novel SNP rs55944529 located at intron 8 was found to be significantly higher in the original large patient sample (p = 0.016). This allele was associated with a higher level of DAO mRNA expression in the Epstein-Barr virus-transformed lymphocytes. The haplotype distribution of a haplotype block composed of rs11114083-rs2070586-rs2070587-rs55944529 across intron 1 and intron 8 was significantly different between the patients and controls and the haplotype frequencies of AAGC were significantly higher in patients, in both the original (corrected p < 0.0001) and replicated samples (corrected p = 0.0003). The CGTC haplotype was specifically associated with the subgroup with deficits in sustained attention and executive function and the AAGC haplotype was associated with the subgroup without such deficits. The DAO gene was a susceptibility gene for schizophrenia and the genomic region between intron 1 and intron 8 may harbor functional genetic variants, which may influence the mRNA expression of DAO and neurocognitive functions in schizophrenia

“Real impact”: challenges and opportunities in bridging the gap between research and practice – making a difference in industry, policy, and society

Achieving impact from academic research is a challenging, complex, multifaceted, and interconnected topic with a number of competing priorities and key performance indicators driving the extent and reach of meaningful and measurable benefits from research. Academic researchers are incentivised to publish their research in high-ranking journals and academic conferences but also to demonstrate the impact of their outputs through metrics such as citation counts, altmetrics, policy and practice impacts, and demonstrable institutional decision-making influence. However, academic research has been criticized for: its theoretical emphasis, high degree of complexity, jargon-heavy language, disconnect from industry and societal needs, overly complex and lengthy publishing timeframe, and misalignment between academic and industry objectives. Initiatives such as collaborative research projects and technology transfer offices have attempted to deliver meaningful impact, but significant barriers remain in the identification and evaluation of tangible impact from academic research. This editorial focusses on these aspects to deliver a multi-expert perspective on impact by developing an agenda to deliver more meaningful and demonstrable change to how “impact” can be conceptualized and measured to better align with the aims of academia, industry, and wider society. We present the 4D model - Design, Deliver, Disseminate, and Demonstrate - to provide a structured approach for academia to better align research endeavors with practice and deliver meaningful, tangible benefits to stakeholders.</p