The Taiwan ECDFS Near-Infrared Survey: Ultra-deep J and Ks Imaging in the Extended Chandra Deep Field-South

We present ultra-deep J and Ks imaging observations covering a 30' * 30' area of the Extended Chandra Deep Field-South (ECDFS) carried out by our Taiwan ECDFS Near-Infrared Survey (TENIS). The median 5-sigma limiting magnitudes for all detected objects in the ECDFS reach 24.5 and 23.9 mag (AB) for J and Ks, respectively. In the inner 400 arcmin^2 region where the sensitivity is more uniform, objects as faint as 25.6 and 25.0 mag are detected at 5-sigma. So this is by far the deepest J and Ks datasets available for the ECDFS. To combine the TENIS with the Spitzer IRAC data for obtaining better spectral energy distributions of high-redshift objects, we developed a novel deconvolution technique (IRACLEAN) to accurately estimate the IRAC fluxes. IRACLEAN can minimize the effect of blending in the IRAC images caused by the large point-spread functions and reduce the confusion noise. We applied IRACLEAN to the images from the Spitzer IRAC/MUSYC Public Legacy in the ECDFS survey (SIMPLE) and generated a J+Ks selected multi-wavelength catalog including the photometry of both the TENIS near-infrared and the SIMPLE IRAC data. We publicly release the data products derived from this work, including the J and Ks images and the J+Ks selected multiwavelength catalog.Comment: 25 pages, 25 figures, ApJS in pres

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation

<p>Abstract</p> <p>Background</p> <p>Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis. In preliminarily studies, we observed that arecoline induces detachment of the human-derived hepatoma cell line HA22T/VGH from the extracellular matrix. In the present study, we explored the fate of the detached HA22T/VGH cells and investigated the underlying mechanism.</p> <p>Methods</p> <p>HA22T/VGH cells or primary cultured rat hepatocytes were treated with arecoline, then changes in morphology, viability, apoptosis, and the expression of surface β1-integrin, apoptosis-related proteins, and IL-6 were examined. Furthermore, activation of the signal transducer and activator of transcription 3 (STAT3) pathway and the RhoA/Rock signaling pathway, including p190RhoGAP and Src homology-2 domain-containing phosphatase SHP2, was examined.</p> <p>Results</p> <p>A low concentration of arecoline (≤ 100 μg/ml) caused cytoskeletal changes in HA22T/VGH cells, but not hepatocytes, and this was accompanied by decreased β1-integrin expression and followed by apoptosis, indicating that HA22T/VGH cells undergo anoikis after arecoline treatment. IL-6 expression and phosphorylation of STAT3, which provides protection against anoikis, were inhibited and levels of downstream signaling proteins, including Bcl-X_Land Bcl-2, were decreased, while Bax expression, mitochondrial cytochrome c release, and caspase-3 activity were increased. In addition, phosphorylation/activation of p190RhoGAP, a RhoA inhibitor, and of its upstream regulator, SHP2, was inhibited by arecoline treatment, while Rho/Rock activation was increased. Addition of the RhoA inhibitor attenuated the effects of arecoline.</p> <p>Conclusions</p> <p>This study demonstrated that arecoline induces anoikis of HA22T/VGH cells involving inhibition of STAT3 and increased RhoA/Rock activation and that the STAT3 and RhoA/Rock signaling pathways are connected.</p

Line-of-sight Elongation and Hydrostatic Mass Bias of the Frontier Fields Galaxy Cluster Abell 370

We present a detailed weak-lensing and X-ray study of the Frontier Fields galaxy cluster Abell 370, one of the most massive known lenses on the sky, using wide-field BR C z' Subaru/Suprime-Cam and Chandra X-ray observations. By combining two-dimensional (2D) shear and azimuthally averaged magnification constraints derived from Subaru data, we perform a lensing mass reconstruction in a free-form manner, which allows us to determine both the radial structure and 2D morphology of the cluster mass distribution. In a triaxial framework assuming a Navarro-Frenk-White density profile, we constrain the intrinsic structure and geometry of the cluster halo by forward modeling the reconstructed mass map. We obtain a halo mass M 200 = (1.54 ± 0.29) ×1015 h -1 M ⊙, a halo concentration c 200 = 5.27 ± 1.28, and a minor-major axis ratio q a = 0.62 ± 0.23 with uninformative priors. Using a prior on the line-of-sight alignment of the halo major axis derived from binary merger simulations constrained by multi-probe observations, we find that the data favor a more prolate geometry with lower mass and lower concentration. From triaxial lens modeling with the line-of-sight prior, we find a spherically enclosed gas mass fraction of f gas = (8.4 ± 1.0)% at 0.7 h -1 Mpc ~ 0.7r 500. When compared to the hydrostatic mass estimate (M HE) from Chandra observations, our triaxial weak-lensing analysis yields spherically enclosed mass ratios of 1 - b ≡ M HE/M WL = 0.56 ± 0.09 and 0.51 ± 0.09 at 0.7 h -1 Mpc with and without using the line-of-sight prior, respectively. Since the cluster is in a highly disturbed dynamical state, this represents the likely maximum level of hydrostatic bias in galaxy clusters

A Wide and Deep Exploration of Radio Galaxies with Subaru HSC (WERGS). II. Physical Properties derived from the SED Fitting with Optical, Infrared, and Radio Data

We present physical properties of radio galaxies (RGs) with $f_{\rm 1.4 GHz} >$ 1 mJy discovered by Subaru Hyper Supreme-Cam (HSC) and VLA Faint Images of the Radio Sky at Twenty-Centimeters (FIRST) survey. For 1056 FIRST RGs at $0 < z \leq 1.7$ with HSC counterparts in about 100 deg$^2$, we compiled multi-wavelength data of optical, near-infrared (IR), mid-IR, far-IR, and radio (150 MHz). We derived their color excess ($E (B-V)_{*}$), stellar mass, star formation rate (SFR), IR luminosity, the ratio of IR and radio luminosity ($q_{\rm IR}$), and radio spectral index ($\alpha_{\rm radio}$) that are derived from the SED fitting with CIGALE. We also estimated Eddington ratio based on stellar mass and integration of the best-fit SEDs of AGN component. We found that $E (B-V)_{*}$, SFR, and IR luminosity clearly depend on redshift while stellar mass, $q_{\rm IR}$, and $\alpha_{\rm radio}$ do not significantly depend on redshift. Since optically-faint ($i_{\rm AB} \geq 21.3$) RGs that are newly discovered by our RG survey tend to be high redshift, they tend to not only have a large dust extinction and low stellar mass but also have high SFR and AGN luminosity, high IR luminosity, and high Eddington ratio compared to optically-bright ones. The physical properties of a fraction of RGs in our sample seem to differ from a classical view of RGs with massive stellar mass, low SFR, and low Eddington ratio, demonstrating that our RG survey with HSC and FIRST provides us curious RGs among entire RG population.Comment: 30 pages, 20 figures, and 4 tables, accepted for publication in ApJS. The catalog and SED template of radio galaxies will be accessible through an online servic