24 research outputs found
The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir
No full textAtomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis
No full textG-patch: a new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins
No full textPR Domain of Rous Sarcoma Virus Gag Causes an Assembly/Budding Defect in Insect Cells
No full textWhile baculovirus expression of Gag proteins from numerous retroviruses has led reliably to production of virus-like particles (VLPs), we observed that expression of Rous sarcoma virus Gag failed to produce VLPs. Transmission and scanning electron microscopy analysis revealed that the Gag protein reached the plasma membrane but was unable to correctly form particles. Addition of a myristylation signal had no effect on the budding defect, but deletion of the PR domain of Gag restored normal budding. The resulting VLPs were morphologically distinct from human immunodeficiency virus type 1 VLPs expressed in parallel
C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity
No full textComparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases
No full text
