Implementing Cross-Organizational Business Processes with Enterprise Mashups: Hype or Reality?

Many cross-organizational business processes are implemented by hubs and integration platforms which support the electronic collaboration of multiple organizations. The available concepts and solutions based on service-oriented architectures focus on the automatization of long-term business relationships. However, they often do not provide intuitive ways to modify them according to situational needs. In particular, small and medium-sized enterprises characterized by limited know-how and resources are excluded in such electronic collaborations. This paper demonstrates how the user-driven development paradigm of enterprise mashups could be leveraged for implementing cross-organizational business processes. By means of a case study, we report about the experiences of a real-world scenario we have implemented in the frame of the EU-funded research project FAST. A business value analysis highlights the automational, informational and transformational effects. An organized laboratory experiment evaluates how the actual users create enterprise mashups for cross-organizational processes. We conclude with the benefits and limitations of the paradigm

IT impacts on operation-level agility in service industries

A new kind of Web-based application, known as Enterprise Mashups, has gained momentum in the last years: Business users with no or limited programming skills are empowered to leverage in a collaborative manner user friendly building blocks and to combine and reuse existing Web-based resources within minutes to new value added applications in order to solve an individual and ad-hoc business problem. Current discussions of the Mashup paradigm in the scientific community are limited on technical aspects. The collaboration and the peer production management aspects of the Mashup development have received less attention yet. In this paper, we propose a reference model for Enterprise Mashups which provides a foundation to develop and to analyse grassroots Enterprise Mashup environments from a managerial and collaborative perspective. By following the design science research approach, we investigate existing reference models and leverage the St. Gallen Media Reference Model (MRM). The development of Enterprise Mashups is structured by market transaction phases similar to electronic markets. The user roles, the necessary processes and the resulting services are modelled according to the views of the MRM. By means of the SAP Research RoofTop Marketplace prototype we demonstrate the application of the designed reference model for grassroots Enterprise Mashups environments

Web 2.0-Entwicklung — ewige Beta-Version

Zusammenfassung: Eine neue Generation von internetbasierten Community-Plattformen wie YouTube, Flickr oder del.icio.us hat in den letzten Jahren groβes Interesse in Forschung und Industrie hervorgerufen. Diese Plattformen beziehen den Nutzer als zentralen Teil des Applikationsdesigns explizit mit ein und prägen einen neuen Trend in der Entwicklung von Web-Anwendungen. Zahlreiche Funktionalitäten, die exakt den Bedürfnissen der Nutzer entsprechen, können so bereitgestellt und kontinuierlich weiterentwickelt werden. Dem Paradigma der ewigen Beta-Version entsprechend, stellen Web 2.0-basierte Anwendungen keine statischen Softwareartefakte mehr da. Sie sind vielmehr dezentrale Dienste, die sowohl von Nutzern als auch von Betreibern ständig angepasst werden können. Die fortwährende Anpassung von Web 2.0-Plattformen stellt insbesondere an den Entwicklungsprozess neue Anforderungen. Durch Anwendung von klassischen Methoden der Softwareentwicklung können diese nicht erfüllt werden. Dieser Artikel beschreibt damit verbundene Herausforderungen und mögliche Lösungsansätze und illustriert diese mit zahlreichen Beispiele

Study protocol of the FIRE-8 (AIO-KRK/YMO-0519) trial: a prospective, randomized, open-label, multicenter phase II trial investigating the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line treatment in patients with metastatic colorectal cancer

Background: Initial systemic therapy for patients with metastatic colorectal cancer (mCRC) is usually based on two- or three-drug chemotherapy regimens with fluoropyrimidine (5-fluorouracil (5-FU) or capecitabine), oxaliplatin and/or irinotecan, combined with either anti-VEGF (bevacizumab) or, for RAS wild-type (WT) tumors, anti-EGFR antibodies (panitumumab or cetuximab). Recommendations for patients who are not eligible for intensive combination therapies are limited and include fluoropyrimidine plus bevacizumab or single agent anti-EGFR antibody treatment. The use of a monochemotherapy concept of trifluridine/ tipiracil in combination with monoclonal antibodies is not approved for first-line therapy, yet. Results from the phase II TASCO trial evaluating trifluridine/tipiracil plus bevacicumab in first-line treatment of mCRC patients and from the phase I/II APOLLON trial investigating trifluridine/tipiracil plus panitumumab in pre-treated mCRC patients suggest favourable activity and tolerability of these new therapeutic approaches. Methods: FIRE-8 (NCT05007132) is a prospective, randomized, open-label, multicenter phase II study which aims to evaluate the efficacy of first-line treatment with trifluridine/tipiracil (35 mg/m(2) body surface area (BSA), orally twice daily on days 1-5 and 8-12, q28 days) plus either the anti-EGFR antibody panitumumab (6 mg/kg body weight, intravenously on day 1 and 15, q28 days) [arm A] or (as control arm) the anti-VEGF antibody bevacizumab (5 mg/kg body weight, intravenously on day 1 and 15, q28 days) [arm B] in RAS WT mCRC patients. The primary objective is to demonstrate an improved objective response rate (ORR) according to RECIST 1.1 from 30% (control arm) to 55% with panitumumab. With a power of 80% and a two-sided significance level of 0.05, 138 evaluable patients are needed. Given an estimated drop-out rate of 10%, 153 patients will be enrolled. Discussion: To the best of our knowledge, this is the first phase II trial to evaluate the efficacy of trifluridine/tipiracil plus panitumumab in first-line treatment of RAS WT mCRC patients. The administration of anti-EGFR antibodies rather than anti-VEGF antibodies in combination with trifluridine/tipiracil may result in an increased initial efficacy

Myeloperoxidase induces monocyte migration and activation after acute myocardial infarction

IntroductionMyocardial infarction (MI) is a significant contributor to morbidity and mortality worldwide. Many individuals who survive the acute event continue to experience heart failure (HF), with inflammatory and healing processes post-MI playing a pivotal role. Polymorphonuclear neutrophils (PMN) and monocytes infiltrate the infarcted area, where PMN release high amounts of the heme enzyme myeloperoxidase (MPO). MPO has numerous inflammatory properties and MPO plasma levels are correlated with prognosis and severity of MI. While studies have focused on MPO inhibition and controlling PMN infiltration into the infarcted tissue, less is known on MPO’s role in monocyte function.Methods and resultsHere, we combined human data with mouse and cell studies to examine the role of MPO on monocyte activation and migration. We revealed a correlation between plasma MPO levels and monocyte activation in a patient study. Using a mouse model of MI, we demonstrated that MPO deficiency led to an increase in splenic monocytes and a decrease in cardiac monocytes compared to wildtype mice (WT). In vitro studies further showed that MPO induces monocyte migration, with upregulation of the chemokine receptor CCR2 and upregulation of inflammatory pathways identified as underlying mechanisms.ConclusionTaken together, we identify MPO as a pro-inflammatory mediator of splenic monocyte recruitment and activation post-MI and provide mechanistic insight for novel therapeutic strategies after ischemic injury

Towards a reference model for grassroots enterprise mashup environments

A new kind of Web-based application, known as Enterprise Mashups, has gained momentum in the last years: Business users with no or limited programming skills are empowered to leverage in a collaborative manner user friendly building blocks and to combine and reuse existing Web-based resources within minutes to new value added applications in order to solve an individual and ad-hoc business problem. Current discussions of the Mashup paradigm in the scientific community are limited on technical aspects. The collaboration and the peer production management aspects of the Mashup development have received less attention yet. In this paper, we propose a reference model for Enterprise Mashups which provides a foundation to develop and to analyse grassroots Enterprise Mashup environments from a managerial and collaborative perspective. By following the design science research approach, we investigate existing reference models and leverage the St. Gallen Media Reference Model (MRM). The development of Enterprise Mashups is structured by market transaction phases similar to electronic markets. The user roles, the necessary processes and the resulting services are modelled according to the views of the MRM. By means of the SAP Research RoofTop Marketplace prototype we demonstrate the application of the designed reference model for grassroots Enterprise Mashups environments